cFLIP protein prevents tumor necrosis factor-α-mediated induction of caspase-8-dependent apoptosis in insulin-secreting βTc-Tet cells

Diabetes

Volumn 51, Issue 6, 2002, Pages 1805-1814

  Cottet, Sandra ^a   Dupraz, Philippe ^a   Hamburger, Fabienne ^a   Dolci, Wanda ^a   Jaquet, Muriel ^a   Thorens, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FLICE INHIBITORY PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NEUTROPHIL CHEMOTAXIS; OUTCOMES RESEARCH; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0036266124     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.6.1805     Document Type: Article

References (62)

1. The beta cell in autoimnmne diabetes: Many mechanisms and pathways of loss
2. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays
3. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
4. Beta-cell apoptosis and defense mechanisms: Lessons from type 1 diabetes
5. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
6. Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells
7. IFN-gamma and tumor necrosis factor-alpha: Cytotoxicity to murine islets of Langerhans
8. Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets: Extent of nitric oxide involvement
9. Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
10. Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
11. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
12. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
13. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
14. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
15. Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects
16. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
17. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death
18. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
19. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
20. Apoptosis signaling in lymphocytes
21. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
22. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
23. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
24. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis
25. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
26. The human tumor necrosis factor (TNF) receptorassociated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase
27. The Re1/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L)
28. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
29. Inhibition of death receptor signals by cellular FLIP
30. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
31. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis
32. CASH, a novel caspase homologue with death effector domains
33. Casper is a FADD- and caspase-related inducer of apoptosis
34. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
35. MRIT, a novel death-effector domaincontaining protein, interacts with caspases and BclXL and initiates cell death
36. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
37. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways
38. Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene
39. Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion
40. Dominant negative MyD88 proteins inhibit interleukin-1beta/interferon-gamma-mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells
41. SOCS-1 protein prevents Janus kinase/STAT-dependent inhibition of β cell insulin gene transcription and secretion in response to IFN-γ
42. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
43. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
44. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
45. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
46. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
47. Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic beta cells: Comparison with the effects of fatty acids
48. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
49. DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water
50. Biochemical pathways of caspase activation during apoptosis
51. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
52. Interferon-γ induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1 dependent mechanism
53. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
54. Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells
55. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death
56. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor
57. Tumor necrosis factor-alpha signals to the IFN-gamma receptor complex to increase Stat1alpha activation
58. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
59. Control of apoptosis by Rel/NF-kB transcription factors
60. Inhibition of cytokine-induced NF-κB activation by adenovirusmediated expression of a NF-κB super-repressor prevents β-cell apoptosis
61. Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor
62. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1beta on mouse pancreatic islets mainly via generation of nitric oxide