Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic β-cell line MIN6

Cell Structure and Function

Volumn 24, Issue 6, 1999, Pages 451-455

  Nakata, Masanori ^a   Uto, Nobue ^a   Maruyama, Ikuro ^a   Yada, Toshihiko ^a,b  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Apoptosis; Cytoplasmic Ca2+; Diabetes; Nitric oxide; Pancreatic cell; Protease

Indexed keywords

CALCIUM ION; CALPAIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; NITRIC OXIDE; PROTEINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CALCIUM; CELL SURVIVAL; CHELATING AGENTS; DIABETES MELLITUS, TYPE 1; EGTAZIC ACID; INSULINOMA; ISLETS OF LANGERHANS; MICE; NITRIC OXIDE; NITRIC OXIDE DONORS; PANCREAS; PANCREATIC NEOPLASMS; PENICILLAMINE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033510053     PISSN: 03867196     EISSN: None     Source Type: Journal    
DOI: 10.1247/csf.24.451     Document Type: Article

References (12)

1. 2+ concentration. J. Biol. Chem., 273: 33501-33507.
2. EIZIRKI, D.L., CAGLIERO, E., BJORKLUND, A., and WELSH, N. 1992. Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages. FEBS Lett., 308: 249-252.
3. 2+ channels exposed to serum from patients with type I diabetes. Science, 261: 86-90.
4. KANETO, H., FUJII, J., SEO, H.G., SUZUKI, K., MATSUOKA, T., NAKAMURA, M., TATSUMI, H., YAMASAKI, Y., KAMADA, T., and TANIGUCHI, N. 1995. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes, 44: 733-738.
5. LAFFRANCHI, R., GOGVADZE, V., RICHTER, C., and SPINAS, G.A. 1995. Nitric oxide (nitrogen monoxide, NO) stimulates insulin secretion by inducing calcium release from mitochondria. Biochem. Biophys. Res. Commun., 217: 584-591.
6. MARTIN, S.J. and GREEN, D.R. 1995. Protease activation during apoptosis: death by a thousand cuts? Cell, 82: 349-352.
7. 2+-signaling in rat pancreatic β-cells. Biochem. Biophys. Res. Commun., 235: 619-624.
8. SCHMIDT, H.H.H.W., WARNER, T.D., ISHII, K., SHENG, H., and MURAD, F. 1992. Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science, 255: 721-723.
9. SCHWARTZMAN, R.A. and CIDLOWSKI, J.A. 1993. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr-Rev., 14: 133-151.
10. WANG, L., BHATTACHARJEE, A., FU, J., and LI, M. 1996. Abnormally expressed low-voltage-activated calcium channels in beta-cells from NOD mice and a related clonal cell line. Diabetes, 45: 1678-1683.
11. 2+ mobilization and increases secretion of incorporated 5-hydroxytryptamine in rat pancreatic beta-cells. FEBS Lett., 371: 99-104.
12. YADA, T., SAKURADA, M., IHIDA, K., NAKATA, M., MURATA, F., ARIMURA, A., and KIKUCHI, M. 1994. Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet β-cells. J. Biol. Chem., 268: 1290-1293.