Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 3 45-3, 2002, Pages

  Beil, Michael ^a   Leser, Jürgen ^a   Lutz, Manfred P ^a   Gukovskaya, Anna ^b   Seufferlein, Thomas ^a   Lynch, Grit ^a   Pandol, Stephen J ^b   Adler, Guido ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cholecystokinin; Cytoskeleton; Pancreas; Secretion

Indexed keywords

BENZAMIDINE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CHOLECYSTOKININ; F ACTIN; MONOCLONAL ANTIBODY; PLECTIN;

ACINAR CELL; ACTIN FILAMENT; ACUTE DISEASE; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BIOCHEMISTRY; CELL DAMAGE; CONTROLLED STUDY; CYTOSKELETON; EDEMA; ENZYME ACTIVATION; ENZYME INHIBITION; MOLECULAR DYNAMICS; MOLECULAR STABILITY; NONHUMAN; PANCREAS SECRETION; PANCREATITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

EID: 0036086547     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00042.2001     Document Type: Article

References (52)

1. Secretagogue-induced membrane alterations in dispersed acini from rat pancreas
2. Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture
3. Not just scaffolding: Plectin regulates actin dynamics in cultured cells
4. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis
5. Effects of high concentrations of secretagogues on the morphology and secretory activity of the pancreas: A role for microfilaments
6. Caspases: The executioners of apoptosis
7. Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells
8. A panel of monoclonal antibodies to rat plectin: Distinction by epitope mapping and immunoreactivity with different tissues and cell lines
9. Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin
10. Crossroads on cytoskeletal highways
11. Unusual 5′ transcript complexity of plectin isoforms: Novel tissue-specific exons modulate actin binding activity
12. Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy
13. 2+ oscillations induced by cholecystokinin (CCK) and its analog OPE in rat pancreatic acinar cells by low-level protein kinase C activation without transition of the CCK receptor from a high- to low-affinity state
14. Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding
15. Cerulein-induced pancreatitis
16. Disassembly of rat pancreatic acinar cell cytoskeleton during supramaximal secretagogue stimulation
17. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis
18. Weaving a tanged web: The interconnected cytoskeleton
19. Cholecystokinin-induced redistribution of paxillin in rat pancreatic acinar cells
20. The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons
21. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
22. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
23. Human plectin: Organization of the gene, sequence analysis, and chromosome localization (8q24)
24. The Arp2/3 complex: A multifunctional actin organizer
25. Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site
26. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal
27. F-actin-binding proteins
28. Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization
29. Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments
30. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells
31. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell
32. Cholecystokinin JMV-180 and caerulein effects on the pancreatic acinar cytoskeleton
33. cAMP and Ca(2+)-mediated secretion in parotid acinar cells is associated with reversible changes in the organization of the cytoskeleton
34. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells
35. 4 subunit and plectin at multiple molecular sites
36. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini
37. Two CD95 (APO-1/FAS) signaling pathways
38. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
39. Immunolocalization of the intermediate filament-associated protein plectin at focal contacts and actin stress fibers
40. Plectin deficiency results in muscular dystrophy with epidermolysis bullosa
41. Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis
42. Procaspase-3 is a major physiologic target of caspase-8
43. Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton
44. The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing
45. The subapical actin cytoskeleton regulates secretion and membrane retrieval in pancreatic acinar cells
46. Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin
47. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction
48. Role of plectin in cytoskeleton organization and dynamics
49. Occurrence and immunolocalization of plectin in tissues
50. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
51. An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments
52. Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin