Granzyme B-induced apoptosis

Advances in Experimental Medicine and Biology

Volumn 406, Issue , 1996, Pages 219-228

  Greenberg, Arnold H ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CYTOTOXICITY; HUMAN; LYMPHOCYTE ACTIVATION; NATURAL KILLER CELL; PRIORITY JOURNAL; REVIEW; SECRETORY GRANULE; T LYMPHOCYTE;

EID: 0029859388     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-0274-0_23     Document Type: Review

References (69)

1. P.A. Henkart, Mechanism of lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 3:31 (1985).
2. E. Rouvier, M.F. Luciani, and P. Golstein, Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195 (1993).
3. D. Kaegi, F. Vignaux, B. Ledermann, K. Buerki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein, Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528 (1994).
4. B. Lowin, M. Hahne, C. Mattmann, and J. Tschopp, Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370:650 (1994).
5. L.X. Zheng, G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo, Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377:348 (1995).
6. D. Kaegi, B. Ledermann, K. Buerki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner, Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31 (1994).
7. C.M. Walsh, M. Matloubian, Liu, C.C. Ueda, C.G. Kurahara, J.L. Christensen, M.T.F. Huang, J.D.E. Young, R. Ahmed, and W.R. Clark, Immune function in mice lacking the perforin gene. Proceedings. of. the. National. Academy. of. Sciences. of. the. United. States. of. America. 91:10854 (1994).
8. A.H. Greenberg, and D.W. Litchfield. Granzymes and apoptosis: Targeting the cell cycle. In Pathways for cytolysis. G.M. Griffiths and J. Tschopp, editors. Current Topics in Microbiology and Immunology. 198:95 (1995).
9. G.M. Griffiths, and Y. Argon, Structure and biogenesis of lytic granules. In Pathways for cytolysis. G.M. Griffiths and J. Tschopp, editors. Current Topics in Microbiology and Immunology 198:39 (1995).
10. P.A. Henkart, M.S. Williams, and H. Nakajima, Degranulating cytotoxic lymphocytes inflict multiple damage pathways on target cells. In Pathways for cytolysis. G.M. Griffiths and J. Tschopp, editors. Current Topics in Microbiology and Immunology 198:75 (1995).
11. B. Lowin, M.C. Peitsch, and J. Tschopp, Perforin and Granzymes: Crucial effector moleucles in cytolytic T lymphocyte and ntural killer cell-mediated cytotoxicity. In Pathways for cytolysis. G.M. Griffiths and J. Tschopp, editors. Current Topics in Microbiology and Immunology 198:1 (1995).
12. M.J. Smyth, and J. A. Trapani, Granzymes: Exogenous proteinases that induce target cell apoptosis. Immunology Today 16:202 (1995).
13. J.W. Heusel, R.L. Wesselschmidt, S. Shresta, J.H. Russell, and T. J. Ley, Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977 (1994).
14. C.C Liu, C.M. Walsh, and J.D.E. Young , Perforin: Structure and function. Immunology Today 16:194 (1995).
15. L. Shi, R.P. Kraut, R. Aebersold, and A.H. Greenberg, A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J. Exp. Med. 175:553 (1992).
16. L. Shi, C.M. Kam, J.C. Powers, R. Aebersold, and A.H. Greenberg, Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J. Exp. Med. 176:1521 (1992).
17. D. Masson, and J. Tschopp, A family of serine esterases in lytic granules of cytolytic T lymphoyctes. Cell 49:679 (1987).
18. M. Poe, J.T. Blake, D.A. Boulton, M. Gammon, N.H. Sigal, J.K. Wu, and H.J. Zweerink, Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J. Biol. Chem. 266:98 (1991).
19. S. Odake, C.M. Kam, L. Narasimhan, M. Poe, J.T. Blake, O. Krahenbuhl, J. Tschopp, and J.C. Powers, Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 30:2217 (1991).
20. H. Nakajima, H.L. Park, and P.A. Henkart, Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J. Exp. Med. 181:1037 (1995).
21. J.W. Shiver, and P. A. Henkart, A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene. Cell 64:1175 (1991).
22. J.W. Shiver, L. Su, and P.A. Henkart, Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A. Cell 71:315 (1992).
23. S. Shresta, D.M. MacIvor, J.W. Heusel, J.H. Russell, and T.J. Ley, Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proceedings. of. the. National. Academy. of. Sciences. of. the. United. States. of. America. 92:5679 (1995).
24. K. Ebnet, M. Hausmann, F. Lehmann-Grube, A. Muellbacher, M. Kopf, M. Lamers, and M.M. Simon, Granzyme A-deficient mice retain potent cell-mediated cytotoxicity. EMBO Journal. 14:4230 (1995).
25. R.E. Ellis, J.Y. Yuan, and H.R. Horvitz, Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7:663 (1991).
26. M.O. Hengartner, and H.R. Horvitz, Programmed cell death in Caenorhabditis elegans. Current. Opinion. in Genetics and. Development 4:581 (1994).
27. M.O. Hengartner, and H.R. Horvitz, C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76:665 (1994).
28. J.Y. Yuan, and H.R. Horvitz, The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev. Biol. 138:33 (1990).
29. J. Yuan, S. Shaham, S. Ledoux, H.M. Ellis, and H.R. Horvitz, The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 Beta-converting enzyme. Cell 75:641 (1993).
30. C. Norbury, and P. Nurse, Animal cell cycles and their control. Annu. Rev. Biochem. 61:441 (1992).
31. D.O. Morgan, Principles of CDK regulation. Nature 374:131 (1995).
32. W. Krek, and E.A. Nigg, Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J. 10:3331 (1991).
33. R. Heald, M. McLoughlin, and F. McKeon, Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74:463 (1993).
34. L. Shi, W.K. Nishioka, J. Th'ng, E.M. Bradbury, D.W. Litchfield, and A.H. Greenberg, Premature p34cdc2 activation required for apoptosis. Science 263:1143 (1994).
35. G. Chen, L. Shi, D.W. Litchfield, and A.H. Greenberg, Rescue from granzyme B-induced apoptosis by Wee1 kinase. Journal. of. Experimental. Medicine 181:2295 (1995).
36. A.J. Darmon, D.W. Nicholson, and R.C. Bleackley, Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377:446 (1995).
37. N. Khalil, S.C. Battistuzzi, R.P. Kraut, L.C. Schwarz, and A.H. Greenberg, Growth factor-initiated proliferation of mouse embryonic fibroblasts induces cytotoxicity by natural killer cells and by a non-cytolysin cytotoxin in natural killer granules. J. Immunol. 145:1286 (1990).
38. W.K. Nishioka, and R.M. Welsh, Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target. J. Exp. Med. 179:769 (1994).
39. L.L. Parker, and H. Piwnica Worms, Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257:1955 (1992).
40. C.H. McGowan, and P. Russell, Cell cycle regulation of human WEE1. EMBO Journal. 14:2166 (1995).
41. C.J. Li, D.J. Friedman, C. Wang, V. Metelev, and A.B. Pardee, Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268:429 (1995).
42. J.L. He, S. Choe, R. Walker, P. Di Marzio, D.O. Morgan, and N.R. Landau, Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. Journal. of. Virology 69:6705 (1995).
43. F. Re, D. Braaten, E.K. Franke, and J. Luban, Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. Journal. of. Virology 69:6859 (1995).
44. R. Fotedar, J. Flatt, S. Gupta, R.L. Margolis, P. Fitzgerald, H. Messier, and A. Fotedar, Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B. Molecular. and. Cellular. Biology. 15:932 (1995).
45. N. Watanabe, M. Broome, and T. Hunter, Regulation of the human WEE1 Hu CDK tyrosine 15-kinase during the cell cycle. EMBO Journal. 14:1878 (1995).
46. L. Wu, and P. Russell, Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Nature 363:738 (1993).
47. J.M. Lahti, J. Xiang, L.S. Heath, D. Campana, and V.J. Kidd, PITSLRE protein kinase activity is associated with apoptosis. Molecular. and. Cellular. Biology. 15:1 (1995).
48. S.J. Martin, A.J. McGahon, W.K. Nishioka, D. La Face, X. Guo, J. Th'ng, E.M. Bradbury, and D.R. Green, p34cdc2 and apoptosis. Science 269:106 (1995).
49. A.H. Greenberg, and D.W. Litchfield, p34cdc2 and apoptosis. Response. Science 269:107 (1995).
50. R.S. Freeman, S. Estus, and E.M. Johnson Jr, Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death. Neuron 12:343 (1994).
51. M. Miura, H. Zhu, R. Rotello, E.A. Hartwieg, and J. Yuan, Induction of apoptosis in fibroblasts by IL-1Beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-. Cell 75:653 (1993).
52. L. Wang, M. Miura, L. Bergeron, H. Zhu, and J. Yuan, Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739 (1994).
53. V. Gagliardini, P.A. Fernandez, R.K. Lee, H.C. Drexler, R.J. Rotello, M.C. Fishman, and J. Yuan, Prevention of vertebrate neuronal death by the crmA gene [see comments]. Science 263:826 (1994).
54. S.J. Martin, and D.R. Green, Protease activation during apoptosis: Death by a thousand cuts?. Cell 82:349 (1995).
55. S. Kumar, M. Kinoshita, M. Noda, N.G. Copeland, and N.A. Jenkins, Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1Beta-converting enzyme. Genes and. Development 8:1613 (1994).
56. T. Fernandes-Alnemri, G. Litwack, and E.S. Alnemri, CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1Beta-convert ng enzyme. Journal. of. Biological. Chemistry. 269:30761 (1994).
57. C. Faucheu, A. Diu, A.W.E. Chan, A.M. Blanchet, C. Miossec, F. Herve, V. Collard-Dutilleul, Y. Gu, R.A. Aldape, J.A. Lippke, C. Rocher, M.S.S. Su, D.J. Livingston, T. Hercend, and J.L. Lalanne, A novel human protease similar to the interleukin-1 Beta converting enzyme induces apoptosis in transfected cells. EMBO Journal. 14:1914 (1995).
58. N.A. Munday, J.P. Vaillancourt, A. Ali, F.J. Casano, D.K. Miller, S.M. Molineaux, T.T. Yamin, V.L. Yu, and D.W. Nicholson, Molecular cloning and pro-apoptotic activity of ICEreIII and ICEreIIII, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270:15870 (1995).
59. T. Fernandes Alnemri, G. Litwack, and E.S. Alnemri, Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res. 55:2737 (1995).
60. N.A. Thornberry, H.G. Bull, J.R. Calaycay, K.T. Chapman, A.D. Howard, M.J. Kostura, D.K. Miller, S.M. Molineaux, J.R. Weidner, J. Aunins, and et al, A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768 (1992).
61. D.K. Miller, J.M. Ayala, L.A. Egger, S.M. Raju, T.T. Yamin, G.J. Ding, E.P. Gaffney, A.D. Howard, O.C. Palyha, A.M. Rolando, and et al, Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells. J. Biol. Chem. 268:18062 (1993).
62. A.J. Darmon, N. Ehrman, A. Caputo, J. Fujinaga, and R.C. Bleackley, The cytotoxic T cell proteinase granzyme B does not activate interleukin-1Beta-converting enzyme. Journal. of. Biological. Chemistry. 269:32043 (1994).
63. D.W. Nicholson, A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnik, N.A. Munday, S.M. Raju, M.E. Smulson, T.T. Yamin, V. L. Yu, and D.K. Miller, Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37 (1995).
64. M. Tewari, L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, and V.M. Dixit, Yama/CPP32Beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 63. 81:801 (1995).
65. A.J. Darmon, D.W. Nicholson, and R.C. Bleackley, Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 377:446 (1995).
66. P. Li, H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, E. Towne, D. Tracey, S. Wardwell, F. Wei, W. Wong, R. Kamen, and T. Seshadri, Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80:401 (1995).
67. K. Kuida, J.A. Lippke, G. Ku, M.W. Harding, D.J. Livingston, M.S.S. Su, and R.A. Flavell, Altered cytokine export and apoptosis in mice deficient in interleukin-1Beta converting enzyme. Science 267:2000 (1995).
68. C.A. Ray, R.A. Black, S.R. Kronheim, T.A. Greenstreet, P.R. Sleath, G.S. Salvesen, and D.J. Pickup, Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 69:597 (1992).
69. N.J. Bump, M. Hackett, M. Hugunin, S. Seshagiri, K. Brady, P. Chen, C. Ferenz, S. Franklin, T. Ghayur, P. Li, P. Licari, J. Mankovich, L.F. Shi, A.H. Greenberg, L.K. Miller, and W.W. Wong, Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269:1885 (1995).