The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice

Annals of the New York Academy of Sciences

Volumn 958, Issue , 2002, Pages 204-208

  Petrovsky, N ^a,b,d   Silva, D ^a   Socha, L ^a   Slattery, R ^c   Charlton, B ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF CANBERRA   (Australia)

^c Biology and Environment   (Australia)

^d CANBERRA HOSPITAL   (Australia)

Author keywords

Apoptosis; Autoimmunity; Diabetes; Fas; Fas ligand; NOD mice

Indexed keywords

CYTOKINE; FAS LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; AUTOIMMUNE DISEASE; CELL DESTRUCTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN FUNCTION; PROTEIN INTERACTION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0036276370     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb02970.x     Document Type: Conference Paper

References (16)

1. Beta cell apoptosis in T cell-mediated autoimmune diabetes
2. The role of Fas in autoimmune diabetes
3. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
4. Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets
5. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
6. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation
7. Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro
8. Evidence that beta cell death in the nonobese diabetic mouse is Fas independent
9. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis
10. CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR and BALB/c mice
11. Polymorphism of murine Fas ligand that affects the biological activity
12. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice
13. Inhibition of autoimmune diabetes by Fas ligand: The paradox is solved
14. Significant role for Fas in the pathogenesis of autoimmune diabetes
15. Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
16. Fas ligand-mediated mechanisms are involved in autoimmune destruction of islet beta cells in nonobese diabetic mice