Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes

British Journal of Pharmacology

Volumn 133, Issue 6, 2001, Pages 909-919

  Mabley, Jon G ^a   Suarez Pinzon, Wilma L ^b   Haskó, György ^a   Salzman, Andrew L ^a   Rabinovitch, Alex ^b   Kun, Ernest ^c   Szabó, Csaba ^a  

^a INOTEK CORPORATION   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Octamer Research Foundation   (United States)

Author keywords

Diabetes; DNA single strand break; Inducible nitric oxide synthase; Inflammation; Islets of Langerhans; Nitric oxide; Peroxynitrite; Poly (ADP ribose) synthetase; Superoxide

Indexed keywords

BENZO[A]PYRENE DERIVATIVE; CYTOKINE; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PEROXYNITRITE; SINGLE STRANDED DNA; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CELL VIABILITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DISRUPTION; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTECTION;

EID: 0034885522     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704156     Document Type: Article

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