Overexpression of Bcl-X(L) in β-cells prevents cell death but impairs mitochondrial signal for insulin secretion

American Journal of Physiology - Endocrinology and Metabolism

Volumn 278, Issue 2 41-2, 2000, Pages

  Zhou, Yun Ping ^a   Pena, John C ^a   Roe, Michael W ^a   Mittal, Anshu ^a   Levisetti, Matteo ^a   Baldwin, Aaron C ^a   Pugh, William ^a   Ostrega, Diane ^a   Ahmed, Noreen ^a   Bindokas, Vytautas P ^a   Philipson, Louis H ^a   Hanahan, Douglas ^b   Thompson, Craig B ^a   Polonsky, Kenneth S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Calcium; Islets of Langerhans; Mitochondria

Indexed keywords

2 OXOISOCAPROIC ACID; CALCIUM ION; GLUCOSE; INSULIN; POTASSIUM CHLORIDE; PROTEIN BCL X; PYRUVIC ACID DERIVATIVE; THAPSIGARGIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; FOUNDER EFFECT; GENE OVEREXPRESSION; GLUCOSE INTOLERANCE; GLUCOSE OXIDATION; INSULIN RELEASE; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 16744368499     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.278.2.e340     Document Type: Article

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