Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat

Diabetes

Volumn 47, Issue 3, 1998, Pages 358-364

  Pick, Anthony ^b   Clark, Joshua ^b   Kubstrup, Christian ^b   Levisetti, Matteo ^b   Pugh, William ^b   Bonner Weir, Susan ^b   Polonsky, Kenneth S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCAGON; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; PANCREATIC POLYPEPTIDE; PERFUSION; RATS; RATS, ZUCKER; SOMATOSTATIN; TIME FACTORS;

EID: 0031913829     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.3.358     Document Type: Article

References (48)

1. Clark A, Wells CA, Buley ID, Cruickshank JK, Vanhegan RI, Matthews DR, Copper GJS, Holman RR, Turner RC: Islet amyloid, Increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9:151-159, 1988
2. Kloppel G, Lohr M, Habich K, Oberholzer M, Heitz PU: Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Syntk Patkol Res 4:110-125, 1985
3. Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH: Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 3:694-700, 1982
4. Clark JB, Palmer CJ, Shaw WN: The diabetic Zucker Fatty rat. Proc Soc Exp Biol Med 173:68-75, 1983
5. Peterson RG, Shaw WN, Neel MA, Little LA, Eichenberg J: Zucker diabetic fatty rat as a model of non-insulin dependent diabetes mellitus. ILAR News 32:16-19, 1990
6. Tokuyama Y, Sturis J, Depaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI: Evolution of -cell dysfunction in the male Zucker diabetic fatty Rat. Diabetes 44:1447-1457, 1995
7. Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, Tamura N, Hosoda K, Nakao K: Molecular cloning of rat leptin receptor isoform complementary DNAs: identification of a missense mutation in Zucker fatty(fa/fa) rats. Biockem Btopkys Res Commun 225:75-83, 1996
8. Phillips MS, Liu Q, Haznmond HA, Dugan V, Hey PJ, Caskey CT, Hess JF: Leptin receptor missense mutation in the fatty Zucker rat Nat Genet 13:18-19, 1996
9. Kava R, Greenwood MRC, Johnson PR: Zucker (fa/fa) rat, ILAR News 32:34-37, 1990
10. Weibel ER: Stereologic methods. In Practical Methods for Biologic Morphometry. Vol 1, London, Academic Press, 1978, p. 101-161
11. Montana E, Bonner-Weir S, Weir GC: β-cell mass and growth after syngeneic islet cell transplantation in normal and streptozotocin diabetic C57BL/6 mice. J Clin Invest 91:780-787, 1993
12. deFazio A, Leary JA, Hedley DW, Tartersall MHN: Immunohistochemical detection of proliferating cells in vivo. J Histochem Cytochem 36:571-677, 1987
13. Swenne I: The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. Diabetes 31:754-760, 1982
14. Scaglia L, Smith FE, Bonner-Weir S: Apoptosis contributes to the involution of cell mass in the post partum rat pancreas. Endocrinology 136:5461-5468, 1995
15. Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S: Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138:1736-1741, 1997
16. Finegood DT, Scaglia L, Bonner Weir S: Dynamics of -cell mass in the growing rat panrreas: estimation with a simple mathematical model. Diabetes 44:249-256, 1995
17. Sturis J, Pugh W, Tang J, Ostrega DM, Polonsky JS, Polonsky KS: Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat. Am J Physiol 267:E250-E259, 1994
18. Furnsinn C, Komjati M, Madsen OD, Schneider B, Waldhausl W: Histochemical changes in pancreatic islets obtained from obese Zucker rats (fa/fa) on a diabetogenic diet: no evidence for non-enzymatic protein glycation in endocrine cells. Acta Endocrinologica 129:46-53, 1993
19. Ogneva, V, Nikolov B: Changes in pancreatic islets in aging Wistar and Zucker rats: a histochemical and ultrastructural morphometric study. Meek Ageing Dev 74:35-46, 1994
20. Buckingham R, Toseland N, Al-Barazanji K, Gee A, Turner N: BRL 49653, a new insulin sensitizing agent, favorably influences metabolic indices and morphologic changes in pancreas of Zucker Fatty rats (Abstract). Diabetes 45 (Suppl.2):143A, 1996
21. Teiltelman G: Induction of β-cell neogenesis by islet injury. Diabetes Metab Rev 12:91-102, 1996
22. O'Reilly L, Gu AD, Sarvetnick N, Edlund H, Phillips JM, Fulford T, Cooke A: Alpha-cell neogenesis in an animal model of IDDM. Diabetes 46:599-606, 1997
23. Kerr JFR, Gobe GC, Winterford CM, Harmon BV: Anatomical methods in cell death. Methods Cell Biol 46:1-27, 1995
24. Ben-Sasson SA, Sherman Y, Gavrieli Y: Identification of dying cells: in situ staining. Methods Cell Biol 46:29-38, 1995
25. Ramachandra S, Studzinski GP: Morphological and biochemical criteria of apoptosis. Methods Cell Biol 46:119-142, 1995
26. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin dependant diabetes mellitus: prospective study of Pima Indians. N Engl J Med 329:1988-1992, 1993
27. Polonsky KS, Sturis J, Bell GI: Non-insulin dependent diabetes mellitus: a genetically programmed failure of the β-cell to compensate for insulin resistance. N' Engl J Med 334:777-783, 1996
28. Bonner-Weir S: Regulation of pancreatic β-cell mass in vivo. Recent Prog Horm Res 49:91-104, 1994
29. Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR: Development of a novel polygenic model of non-insulin dependent diabetes mellitus in mice heterozygous for insulin receptor and IRS-1 null alleles. Cell 88:561-572, 1997
30. Milburn JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH: Pancreatic B-cells in obesity: evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 270:1295-1299, 1995
31. Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH: Defective fatty acid-mediated -cell compensation in Zucker diabetic fatty rats: pathogenic implications for obesity-dependant diabetes. J Biol Chem 271:5633-5637, 1996
32. Sreenan S, Sturis J, Pugh W, Durant CB, Polonsky KS: Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physiol 271:E742-E747, 1996
33. Ohneda M, Inman LR, Unger RH: Caloric restriction in obese pre-diabetic rats prevents β-cell depletion, loss of β-cell GLUT 2, and glucose incompetence. Diatetotogto 38:173-179, 1995
34. Sturis J, Pugh W, Tang J, Polonsky KS: Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat. Am J Physiol 269:E786-E792, 1995
35. Zhu M, Noma Y, Mizuno A, Sano T, Shima K: Poor capacity for proliferation of pancreatic β-cells in Otsuka-Long-Evans-Tbkushima rat: a model of spontaneous NIDDM. Diabetes 45:941-946, 1996
36. Movassat J, Saulnier C, Serradas P, Portha B: Impaired development of pancreatic β-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia 40:916-925, 1997
37. Coles HSR, Burne JF, Raff MC: Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 118:777-784, 1993
38. Cockburn BN, Ostrega DM, Sturis J, Kupstrup K, Polonsky KS, Bell GI: Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. Diabetes 46:1434-1439, 1997
39. Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications. Diabetes 44:863-870, 1995
40. Lee Y, Hirose H, Zhou Y, Esser V, McGarry JD, Unger RH: Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM, Diabetes 46:408-413, 1997
41. Coleman DL: Lessons from studies with genetic forms of diabetes in the mouse. Metabolism 32 (Suppl. 1):162-164, 1983
42. Swenne I, Andersson A: Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27:464-467, 1984
43. Welsh M, Mares J, Oberg C, Karlsson T: Genetic factors of importance for βcell proliferation. Diabetes Metab Rev 9:25-36, 1993
44. Ling Z, Hannaert JC, Pipeleers D: Effect of nutrients, hormones, and serum on survival of rat islet β-cells in culture. Diabetologia 37:15-21, 1994
45. Ankarcrona M, Dypbukt JM, Brune B, Nicotera P: Interleukin-1-β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp Cell Res 213:172-177, 1994
46. Iwahashi H, Hanafusa T, Eguchi Y, Nakajima H, Miyagawa J, Itoh N, Tomita K, Namba M, Kuwajima M, Noguchi T, Tsujimoto Y, Matsuzawa Y: Cytokineinduced apoptotic cell death in a mouse pancreatic β-cell line: inhibition by Bcl-2. Diabetologia 39:530-536, 1996
47. Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D: Glucose promotes survival of rat pancreatic B cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574, 1996
48. Chung W, Zheng M, Chua M, Kershaw E, Power-Kehoe L, Tsuji M, Wu-peng XS, Williams J, Chua SC, Leibel RL: Genetic modifiers of Lepr fa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41:332-344, 1997