Initiator caspases in apoptosis signaling pathways

Apoptosis

Volumn 7, Issue 4, 2002, Pages 313-319

  Chen, M ^a   Wang, Jin ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Caspase 10; Crystal structures; Death receptors; Isoforms; Mitochondrion; Procaspase; Processing

Indexed keywords

ADAPTOR PROTEIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CASPASE 10; CASPASE 8; CASPASE 9; CELL ADHESION MOLECULE; CYTOCHROME C; ISOPROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CRYSTAL STRUCTURE; CYTOSOL; ENZYME ACTIVATION; MITOCHONDRION; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; FORECASTING; MOUSE; PHYSIOLOGY;

ANIMAL; APOPTOSIS; CASPASES; FORECASTING; MICE; MITOCHONDRIA; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

EID: 0036022407     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016167228059     Document Type: Review

References (70)

1. The TNF and TNF receptor superfamilies: Integrating mammalian biology
2. Death receptors: Signaling and modulation
3. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
4. FADD a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
5. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
6. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
7. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
8. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
9. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10. The expanding role of mitochondria in apoptosis
11. Molecular characterization of mitochondrial apoptosis-inducing factor
12. Apoptosis-inducing factor(AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
13. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
14. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
15. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
16. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
17. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
18. Fas-associated death domain protein interleukin-lbeta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling
19. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
20. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
21. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
22. Apo2L/TRAlL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
23. TRAIL receptor-2 signals apoptosis through FADD and caspase-8
24. Caspase-10 is an initiator caspase in death receptor signaling
25. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8
26. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
27. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment
28. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria
29. Defects in regulation of apoptosis in caspase-2-deficient mice
30. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
31. ICEBERG: A novel inhibitor of interleukin-1 beta generation
32. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
33. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
34. Caspases in T-cell receptor-induced thymocyte apoptosis
35. NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
36. The three-dimensional solution structure and dynamic properties of the human FADD death domain
37. Mutational analysis and NMR studies of the death domain of the tumor necrosis factor receptor-1
38. Solution structure of the tumor necrosis factor receptor-1 death domain
39. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
40. Crystal structure of Apaf-1 caspase recruitment domain: An alphahelical Greek key fold for apoptotic signaling
41. Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction
42. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
43. Autoproteolytic activation ofpro-caspases by oligomerization
44. Synthetic activation of caspases: Artificial death switches
45. Caspase activation: The induced-proximity model
46. Three-dimensional structure of the apoptosome. Implications for assembly, procaspase-9 binding, and activation
47. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)2 homodimer
48. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
49. Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding
50. Structural basis for the activation of human procaspase-7
51. Dimer formation drives the activation of the cell death protease caspase 9
52. Caspases: Enemies within
53. T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death
54. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway
55. Essential lymphocyte function associated 1 (LFA-1): Intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95
56. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
57. Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP
58. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
59. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
60. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
61. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
62. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
63. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
64. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
65. Structural basis of caspase inhibition by XIAP: Differential roles of the linker versus the BIR domain
66. Structural basis of IAP recognition by Smac/DIABLO
67. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
68. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex
69. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
70. Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10