Biochemical pathways of caspase activation during apoptosis

Annual Review of Cell and Developmental Biology

Volumn 15, Issue , 1999, Pages 269-290

  Budihardjo, I ^a   Oliver, H ^a   Lutter, M ^a   Luo, X ^a   Wang, X ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Apaf 1; Bcl 2; Cell surface death receptor; Cytochrome c; Mitochondria

Indexed keywords

CASPASE; CASPASE 2; CASPASE 8; CASPASE 9; CELL SURFACE RECEPTOR; CYTOCHROME C; CYTOKINE; DEXAMETHASONE; ETOPOSIDE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; ION CHANNEL; PROTEIN BCL 2; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; CELL DEATH; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; APOPTOSIS; CASPASES; ENZYME ACTIVATION; HUMANS; MITOCHONDRIA; RECEPTORS, CELL SURFACE;

ANIMALIA; MAMMALIA;

EID: 0033280669     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.15.1.269     Document Type: Review

References (112)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Identification and characterization of murine caspase-14, a new member of the caspase gene family
3. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
4. Inhibition of Bax channel forming activity by Bcl-2
5. Death receptors: Signaling and modulation
6. P53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency
7. Defects in regulation of apoptosis in caspase-2-deficient mice
8. Cladribine (2-chlorodeoxyadenosine)
9. Involvement of MACH, a novel MORT1/FADD-interacting protease in Fas/Apo-1- and TNF receptor-induced cell death
10. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
11. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
12. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes
13. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
14. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver
15. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
16. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
17. Suppression of tumor necrosis factor-induced cell death by inhibition of apoptosis c-IAP-2 is under NF-kappa B control
18. Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency
19. The C. elegans protein egl-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
20. Regulation of apoptosis by BH3 domains in a cell-free system
21. Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore
22. Proteases to die for
23. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
24. X-linked IAP is a direct inhibitor of cell-death proteases
25. DRONC, an ecdysone-inducible Drosophila caspase
26. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
27. Mechanisms and functions of cell death
28. DrICE is an essential caspase required for apoptotic activity in Drosophila cells
29. Cytochrome c induces caspase-dependent apoptosis in intact hematopoietic cells and overrides apoptosis suppression mediated by bcl-2, growth factor signalling MAP-kinase-kinase and malignant change
30. Human B-lymphocytes and thymocytes but not peripheral blood mononuclear cells accumulate high dATP levels in conditions simulating ADA deficiency
31. TRAIL and its receptors
32. CASH, a novel caspase homolog with death effector domains
33. Caspase cleaved Bid targets mitochondria and is required for cytochrome c release while Bcl-xL prevents this release but not tumor necrosis factor-R1/Fas death
34. Differential requirement for caspase-9 in apoptotic pathways in vivo
35. MRIT, a novel death-effector domain-containing protein, interacts with caspases and Bcl-xL and initiates cell death
36. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19 K
37. The CARD domain: A new apoptotic signalling motif
38. Caspase-14 is a novel developmentally regulated protease
39. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95-induced apoptosis
40. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
41. ERICE, a novel FLICE-activatable caspase
42. Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-xL
43. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death
44. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
45. Inhibition of death receptor signals by cellular FLIP
46. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
47. Bax directly induces release of cytochrome c from isolated mitochondria
48. Relationship of deoxycytidine kinase and cytoplasmic 5′-nucleotidase to the chemotherapeutic efficacy of 2-chloro-deoxyadenosine
49. Apoptosis: A basic biological phenomenon with wide-ranging implication in tissue kinetics
50. The release of cytochrome c from mitochondria: A primary site or bcl-2 regulation of apoptosis
51. Inhibition of the interleukin-1β converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition
52. Mitochondrial control of apoptosis
53. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9.Cell
54. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
55. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
56. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
57. Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c
58. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis
59. Mice deficient in IL-1βconverting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
60. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
61. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
62. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
63. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
64. Mitochondrial permeability transition is a central coordinating event of apoptosis
65. A novel receptor for Apo2L/TRAIL contains a truncated death domain
66. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal
67. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
68. The permeability transition pore complex: A target for apoptosis regulation by caspases and bcl-2-related proteins
69. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
70. Bcl-xL forms an ion channel in synthetic lipid membranes
71. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
72. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo1) death-inducing signaling complex
73. An induced proximity model for caspase-8 activation
74. Apoptosis by death factor
75. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
76. Bim: A novel member of the Bcl-2 family that promotes apoptosis
77. Caspase-9, Bcl-xL and Apaf-1 form a ternary complex
78. Bcl-2, a novel regulator of apoptosis
79. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition
80. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
81. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin- 1β converting enzyme
82. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
83. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
84. Two CD95(APO-1/Fas) signaling pathway
85. Channel formation by antiapoptotic protein Bcl-2
86. Comparison of the channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
87. The diphtheria toxin channel-forming T domain translocates its own NH2-terminal region across planar bilayers
88. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
89. Baculovirus inhibitors of apoptosis (IAPs) block activation of Sf-caspase-1
90. Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades
91. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
92. DCP-1, a Drosophila cell death protease essential for development
93. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
94. Molecular ordering of the Fas-apoptotic pathway: The Fas/Apo-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple CED-3/ICE-like cysteine protease
95. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
96. Mechanisms and genes of cellular suicide
97. A single BIR domain of XIAP sufficient for inhibiting caspases
98. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
99. Caspases: Enemies within
100. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
101. Targeted disruption of the mouse caspase-8 gene ablates cell death induction by the TNF receptors. Fas/Apo-1, and DR3 and is lethal prenatally
102. Mutagenesis of the BH3-domain of BAX identifies residues critical for dimerization and killing
103. BID: A novel BH3 domain-only death agonist
104. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
105. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
106. Autoproteolytic activation of procaspases by oligomerization
107. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
108. Mitochondrial control of nuclear apoptosis
109. Serine phosphorylation of death agonist Bad in response to survival factor results in binding to survival factors results in binding to 14-3-3 not bcl-xL
110. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
111. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9