The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

Chemistry and Biology

Volumn 8, Issue 4, 2001, Pages 357-368

  Rotonda, Jennifer ^a   Garcia Calvo, Margarita ^a   Bull, Herb G ^a   Geissler, Wayne M ^a   McKeever, Brian M ^a   Willoughby, Christopher A ^a   Thornberry, Nancy A ^a   Becker, Joseph W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Autoimmunity; Cell death; Crystal structure; Drug design; X ray

Indexed keywords

ASPARTIC ACID; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASP3 PROTEIN, RAT; CASPASE; CASPASE 3; ENZYME INHIBITOR; GRANZYME; GZMB PROTEIN, HUMAN; GZMB PROTEIN, MOUSE; GZMB PROTEIN, RAT; SERINE PROTEINASE;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; ARTICLE; BINDING SITE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; ELECTRICITY; ENZYME SPECIFICITY; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; ASPARTIC ACID; BINDING SITES; CASPASE 3; CASPASES; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME INHIBITORS; GRANZYMES; HUMANS; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

EID: 0035026112     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00018-7     Document Type: Article

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