Heat shock proteins in the regulation of apoptosis: New strategies in tumor therapy - A comprehensive review

Pharmacology and Therapeutics

Volumn 101, Issue 3, 2004, Pages 227-257

  Sreedhar, Amere Subbarao ^a,b   Csermely, Peter ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

17 AAG; 17 allylamino 17 demethoxy geldanamycin; AIF; Apoptosis; Apoptosis signal regulating kinase 1; Apoptosis inducing factor; Ask1; BAD; BAG; Bcl 2 associated death protein; Cancer; Heat shock proteins; Molecular chaperones; Necrosis; Tumor suppression

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; ACETYLSALICYLIC ACID; AMPHETAMINE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; B CELL LYMPHOMA 2 PROTEIN; CALPAIN; CARBENOXOLONE; CASPASE; CATHEPSIN; CHAPERONE; DOXORUBICIN; GELDANAMYCIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; NUCLEASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME INHIBITOR; PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE; TEPRENONE; UNCLASSIFIED DRUG;

ANOIKIS; APOPTOSIS; BACTERIUM; CANCER; CANCER THERAPY; CELL AGING; CELL DEATH; CELL MEMBRANE; CELL NUCLEUS; CELL PROTECTION; CELL STRUCTURE; CYTOSOL; DOWN REGULATION; ENDOPLASMIC RETICULUM; EUKARYOTE; HOMEOSTASIS; HUMAN; LEUKEMIA; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; TUMOR CELL; TUMOR IMMUNITY; UPREGULATION;

APOPTOSIS; CASPASES; ENZYME ACTIVATION; HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 1542718628     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2003.11.004     Document Type: Review

References (423)

1. Abravaya K., Myers M.P., Murphy S.P., Morimoto R.I. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev. 6:1992;1153-1164.
2. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell. 9:2002;423-432.
3. Agarraberes F.A., Dice J.F.A. Molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci. 114:2001;2491-2499.
4. Agatsuma T., Ogawa H., Akasaka K., Asai A., Yamashita Y., Mizukami T., Akinaga S., Saitoh Y. Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities. Bioorg Med Chem. 10:2002;3445-3454.
5. Ahmad M., Srinivasula S.M., Hegde R., Mukattash R., Fernandes-Alnemri T., Alnemri E.S. Identification and characterization of murine caspase-14, a new member of the caspase family. Cancer Res. 58:1998;5201-5205.
6. Ahn J.H., Ko Y.G., Park W.Y., Kang Y.S., Chung H.Y., Seo J.S. Suppression of ceramide-mediated apoptosis by HSP70. Mol Cell. 9:1999;200-206.
7. Akalin A., Elmore L.W., Forsythe H.L., Amaker B.A., McCollum E.D., Nelson P.S., Ware J.L., Holt S.E. A novel mechanism for chaperone-mediated telomerase during prostate cancer progression. Cancer Res. 61:2001;4791-4796.
8. Aldrian S., Trautinger F., Frohlich I., Berger W., Micksche M., Kindas-Mugge I. Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro. Cell Stress Chaperones. 7:2002;177-185.
9. Alesse E., Zazzeroni F., Angelucci A., Giannini G., Di Marcotullio L., Gulino A. The growth arrest and down-regulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. Cell Death Differ. 5:1998;381-389.
10. Ali A., Bharadwaj S., O'Carroll R., Ovsenek N. HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes. Mol Cell Biol. 18:1998;4949-4960.
11. bcr-abl and v-src proteins before their degradation by the proteasome. Cell Growth Differ. 11:2000;355-360.
12. Antonyak M.A., Singh U.S., Lee D.A., Boehm J.E., Combs C., Zgola M.M., Page R.L., Cerione R.A. Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis. J Biol Chem. 276:2001;33582-33587.
13. Arch R.H., Thompson C.B. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated actors and activate nuclear factor kappaB. Mol Cell Biol. 18:1998;558-565.
14. Arrigo A.P. Hsp27: novel regulator of intracellular redox state. IUBMB Life. 52:2001;303-307.
15. Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science. 281:1998;1305-1308.
16. Ashok B.T., Kim E., Mittelman A., Tiwari R.K. Proteasome inhibitors differentially affect heat shock protein response in cancer cells. Int J Mol Med. 8:2001;385-390.
17. Bagatell R., Paine-Murreta G.D., Taylor C.W., Pulcini E.J., Akinaga S., Benjamin I.J., Whitesell L. Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of Hsp90-binding agents. Clin Cancer Res. 6:2000;3312-3328.
18. Baker-LePain J.C., Reed R.C., Nicchitta C.V. ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection. Curr Opin Immunol. 15:2003;89-94.
19. Ballinger C.A., Connell P., Wu Y., Hu Z., Thompson L.J., Yin L.Y., Patterson C. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol. 19:1999;4535-4545.
20. Bando Y., Katayama T., Kasai K., Taniguchi M., Tamatani M., Tohyama M. GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury. Eur J Neurosci. 18:2003;829-840.
21. Bao J.J., Le X.F., Wang R.Y., Yuan J., Wang L., Atkinson E.N., LaPushin R., Andreeff M., Fang B., Yu Y., Bast R.C. Jr. Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. Cancer Res. 62:2002;7264-7272.
22. Barazi H.O., Zhou L., Templeton N.S., Krutzsch H.C., Roberts D.D. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 62:2002;1541-1548.
23. Barry M., Heibein J.A., Pinkoski M.J., Lee S.F., Moyer R.W., Green D.R., Bleackley R.C. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Mol Cell Biol. 20:2000;3781-3794.
24. Basso A.D., Solit D.B., Chiosis G., Giri B., Tsichlis P., Rosen N. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem. 277:2002;39858-39866.
25. Basu S., Binder R.J., Ramalingam T., Srivastava P.K. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity. 14:2001;303-313.
26. Bauer M.K., Vogt M., Los M., Sieger J., Wesslborg S., Schulze-Osthoff K. Role of reactive oxygen species intermediates in activation-induced CD95(APO-1/Fas)ligand expression. J Biol Chem. 273:1998;8048-8055.
27. Beere H.M., Green D.R. Stress management-heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol. 11:2001;6-10.
28. Beere H.M., Wolf B.B., Cain K., Mosser D.D., Mahboubi A., Kuwana T., Tailor P., Morimoto R.I., Cohen G.M., Green D.R. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol. 2:2000;469-475.
29. Bender A.T., Silverstein A.M., Demady D.R., Kanelakis K.C., Noguchi S., Pratt W.B., Osawa Y. Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo. J Biol Chem. 274:1999;1472-1478.
30. Beresford P.J., Jaju M., Friedman R.S., Yoon M.J., Lieberman J. A role for heat shock protein 27 in CTL-mediated cell death. J Immunol. 161:1998;161-167.
31. Berger C.L., Dong Z., Hanlon D., Bisaccia E., Edelson R.L. A lymphocyte cell surface heat shock protein homologous to the endoplasmic reticulum chaperone, immunoglobulin heavy chain binding protein BIP. Int J Cancer. 71:1997;1077-1085.
32. Bergerat A., de Massy B., Gadelle D., Varoutas P.C., Nicolas A., Forterre P. An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature. 386:1997;414-417.
33. Berridge M.J. The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium. 32:2002;235-249.
34. Bezvenyuk Z., Salminen A., Solovyan V. Excision of DNA loop domains as a common step in caspase-dependent and -independent types of neuronal cell death. Brain Res Mol Brain Res. 81:2000;191-196.
35. Bharadwaj S., Ali A., Ovsenek N. Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 in vivo. Mol Cell Biol. 19:1999;8033-8041.
36. Bijur G.N., Jope R.S. Opposing actions of phosphatidylinositol 3-kinase and glycogen synthase kinase-3beta in the regulation of HSF-1 activity. J Neurochem. 75:2000;2401-2408.
37. Billecke S.S., Bender A.T., Kanelakis K.C., Murphy P.J., Lowe E.R., Kamada Y., Pratt W.B., Osawa Y. hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90. J Biol Chem. 277:2002;20504-20509.
38. Binder R.J., Han D.K., Srivastava P.K. CD91 is a receptor for heat shock protein gp96. Nat Immunol. 1:2000;151-155.
39. Binder R.J., Blachere N.E., Srivastava P.K. Heat shock protein-chaperoned peptides but not free peptides introduced into the cytosol are presented efficiently by major histocompatibility complex I molecules. J Biol Chem. 276:2001;17163-17171.
40. Blagosklonny M.V. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia. 16:2002;455-462.
41. Blagosklonny M.V., Fojo T., Bhalla K.N., Kim J.S., Trepel J.B., Figg W.D., Rivera Y., Neckers L.M. The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy. Leukemia. 15:2001;1537-1543.
42. Boehm J.E., Singh U., Combs C., Antonyak M.A., Cerione R.A. Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb. J Biol Chem. 277:2002;20127-20130.
43. Boveris A., Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J. 134:1973;707-716.
44. Braiden V., Ohtsuru A., Kawashita Y., Miki F., Sawada T., Ito M., Cao Y., Kaneda Y., Koji T., Yamashita S. Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter. Hum Gene Ther. 11:2000;2453-2463.
45. Brozovic A., Simaga S., Osmak M. Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia. Neoplasma. 48:2001;99-103.
46. Bruey J.M., Ducasse C., Bonniaud P., Ravagnan L., Susin S.A., Diaz-Latoud C., Gurbuxani S., Arrigo A.P., Kroemer G., Solary E., Garrido C. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2:2000;645-652.
47. Brunton V.G., Steele G., Lewis A.D., Workman P. Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase. Cancer Chemother Pharmacol. 41:1998;417-422.
48. Buchner J. Hsp90 and Co - a holding for folding. Trends Biochem Sci. 24:1999;136-141.
49. Buhling F., Waldburg N., Kruger S., Rocken C., Wiesner O., Weber E., Welte T. Expression of cathepsins B, H, K, L, and S during human fetal lung development. Dev Dyn. 225:2002;14-21.
50. Bukau B., Horwich A.L. The Hsp70 and Hsp60 chaperone machines. Cell. 92:1998;351-366.
51. Buttke T.M., Sandstrom P.A. Redox regulation of programmed cell death in lymphocytes. Free Radic Res. 22:1995;389-397.
52. Byrd C.A., Bornmann W., Erdjument-Bromage H., Tempst P., Pavletich N., Rosen N., Nathan C.F., Ding A. Heat shock protein 90 mediates macrophage activation by taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci USA. 96:1999;5645-5650.
53. Calabrese V., Scapagnini G., Ravagna A., Fariello R.G., Giuffrida Stella A.M., Abraham N.G. Regional distribution of heme oxygenase, HSP70, and glutathione in brain: relevance for endogenous oxidant/antioxidant balance and stress tolerance. J Neurosci Res. 68:2002;65-75.
54. Callahan M.K., Chaillot D., Jacquin C., Clark P.R., Menoret A. Differential acquisition of antigenic peptides by Hsp70 and Hsc70 under oxidative conditions. J Biol Chem. 277:2002;33604-33609.
55. Cande C., Cecconi F., Dessen P., Kroemer G. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci. 115:2002;4727-4734.
56. Cande C., Cohen I., Daugas E., Ravagnan L., Larochette N., Zamzami N., Kroemer G. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie. 84:2002;215-222.
57. Caplan A.J. Hsp90's secrets unfold: new insights from structural and functional studies. Trends Cell Biol. 9:1999;262-268.
58. Caporale L.H. Chance favors the prepared genome. Ann NY Acad Sci. 870:1999;1-21.
59. Cardozo C.P., Michaud C., Ost M.C., Fliss A.E., Yang E., Patterson C., Hall S.J., Caplan A.J. C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. Arch Biochem Biophys. 410:2003;134-140.
60. Carmichael J., Chatellier J., Woolfson A., Milstein C., Fersht A.R., Rubinsztein D.C. Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. Proc Natl Acad Sci USA. 97:2000;9701-9705.
61. Cecconi F. Apaf1 and the apoptotic machinery. Cell Death Differ. 6:1999;1087-1098.
62. Chandrashekar R., Tsuji N., Morales T., Ozols V., Mehta K. An ERp60-like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide isomerase activity. Proc Natl Acad Sci USA. 95:1998;531-536.
63. Chang Y., Abe A., Shayman J.A. Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription. Proc Natl Acad Sci USA. 92:1995;12275-12279.
64. Charette S.J., Lavoie J.N., Lambert H., Landry J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol. 20:2000;7602-7612.
65. Chauhan D., Li G., Hideshima T., Podar K., Mitsiades C., Mitsiades N., Catley L., Tai Y.T., Hayashi T., Shringharpure R., Burger R., Munshi N., Ohtake Y., Saxena S., Anderson K.C. Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 102:2003;3379-3386.
66. Cheetam M.E., Jackson A.P., Anderton B.H. Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b. Eur J Biochem. 226:1994;99-107.
67. Chen D., Androlewicz M.J. Heat shock protein 70 moderately enhances peptide binding and transport by the transporter associated with antigen processing. Immunol Lett. 75:2001;143-148.
68. Chen L., Gao X. Neuronal apoptosis induced by endoplasmic reticulum stress. Neurochem Res. 27:2002;891-898.
69. Chen G., Cao P., Goeddel D.V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell. 9:2002;401-410.
70. Chen J., Xiong J., Liu H., Chernenko G., Tang S.C. Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1 transfected C33A human cervical carcinoma cell line. Oncogene. 21:2002;7050-7059.
71. Chiosis G., Rosen N., Sepp-Lorenzino L. LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 11:2001;909-913.
72. Chiosis G., Lucas B., Shtil A., Huezo H., Rosen N. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem. 10:2002;3555-3564.
73. Chiosis G., Huezo H., Rosen N., Mimnaugh E., Whitesell L., Neckers L. 17AAG: low target binding affinity and potent cell activity - finding an explanation. Mol Cancer Ther. 2:2003;123-129.
74. Chong K.Y., Lai C.C., Lille S., Chang C., Su C.Y. Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection. J Mol Cell Cardiol. 30:1998;599-608.
75. Christopherson K.S., Bredt D.S. Nitric oxide in excitable tissues: physiological roles and disease. J Clin Invest. 100:1997;2424-2429.
76. Chu N.R., Wu H.B., Wu T., Boux L.J., Siegel M.I., Mizzen L.A. Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7. Clin Exp Immunol. 121:2000;216-225.
77. Cirino G., Fiorucci S., Sessa W.C. Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol Sci. 24:2003;91-95.
78. Cissel D.S., Beaven M.A. Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells. J Biol Chem. 275:2000;7066-7070.
79. Clark B.D., Brown I.R. A retinal heat shock protein is associated with elements of the cytoskeleton and binds to calmodulin. Biochem Biophys Res Commun. 139:1986;974-981.
80. Coleman M.L., Sahai E.A., Yeo M., Bosch M., Dewar A., Oslon M.F. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol. 3:2001;339-345.
81. Compton M.M. A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev. 11:1992;105-119.
82. Concannon C.G., Orrenius S., Samali A. Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. Gene Expr. 9:2001;195-201.
83. Cory S., Adams J.M. The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2:2002;647-656.
84. Counis M.F., Torriglia A. Dnases and apoptosis. Biochem Cell Biol. 78:2000;405-414.
85. Craig E.A., Weissman J.S., Horwich A.L. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell. 78:1994;365-372.
86. Crile G. The effects of heat and radiation on cancers implanted on the feet of mice. Cancer Res. 23:1963;372-380.
87. Csermely P. Chaperone overload as a possible contributor to civilization diseases. Trends Genet. 17:2001;701-704.
88. Csermely P. A nonconventional role of molecular chaperones: involvement in the cytoarchitecture. News Physiol Sci. 15:2001;123-126.
89. Csermely P., Kajtár J., Hollósi M., Oikarinen J., Somogyi J. The 90 kDa heat shock protein (hsp90) induces the condensation of the chromatin structure. Biochem Biophys Res Commun. 202:1994;1657-1663.
90. Csermely P., Schnaider T., Szántó I. Signalling and transport through the nuclear membrane. Biochim Biophys Acta. 1241:1995;425-451.
91. Csermely P., Schnaider T., Soti C., Prohaszka Z., Nardai G. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol Ther. 79:1998;129-168.
92. Cuervo A.M., Dice J.F., Knecht E. A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J Biol Chem. 272:1997;5606-5615.
93. Currie R.W., Karmazyn M., Kloc M., Mailer K. Heat shock response is associated with enhanced postischaemic ventricular recovery. Circ Res. 63:1988;543-549.
94. Cutress R.I., Townsend P.A., Brimmell M., Bateman A.C., Hague A., Packham G. BAG-1 expression and function in human cancer. Br J Cancer. 87:2002;834-839.
95. De Giorgi F., Lartigue L., Bauer M.K., Schubert A., Grimm S., Hanson G.T., Remington S.J., Youle R.J., Ichas F. The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. FASEB J. 16:2002;607-609.
96. De Stefanis D.D., Reffo P., Bonelli G., Baccino F.M., Sala G., Ghidoni R., Codogno P., Isidoro C. Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. Biol Chem. 383:2002;989-999.
97. Dias S., Shmelkov S.V., Lam G., Rafii S. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood. 99:2002;2532-2540.
98. Dickson A.J. Apoptosis regulation and its applications to biotechnology. Trends Biotechnol. 16:1998;339-342.
99. Dimmeler S., Assmus B., Hermann C., Haendeler J., Zeicher A.M. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res. 83:1998;334-341.
100. Donze O., Abbas-Terki T., Picard D. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. EMBO J. 20:2001;3771-3780.
101. Doong H., Vrailas A., Kohn E.C. What's in the 'BAG'? - a functional domain analysis of the BAG-family proteins. Cancer Lett. 188:2002;25-32.
102. Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol. 10:1998;262-267.
103. Ellis R.J. The general concept of molecular chaperones. Philos Trans R Soc Lond B Biol Sci. 339:1993;257-261.
104. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1998;43-50.
105. Evan G., Littlewood T. A matter of life and cell death. Science. 281:1998;1317-1322.
106. Fan Z., Beresford P.J., Oh D.Y., Zhang D., Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell. 112:2003;659-672.
107. Fares M.A., Riuz-Gonzalez M.X., Moya A., Elena S.F., Barrio E. Endosymbiotic bacteria: GroEL buffers against deleterious mutations. Nature. 417:2002;398.
108. Feng H., Zeng Y., Graner M.W., Katsanis E. Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells. Blood. 100:2002;4108-4115.
109. Ferrarini M., Heltai S., Zocchi M.R., Rugarli C. Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer. 51:1992;613-619.
110. Ferri K.F., Kroemer G.K. Organelle-specific initiation of cell death pathways. Nat Cell Biol. 3:2001;E255-E263.
111. Fesus L. Transglutaminase-catalyzed protein cross-linking in the molecular program of apoptosis and its relationship to neuronal processes. Cell Mol Neurobiol. 18:1998;683-694.
112. Foghsgaard L., Lademann U., Wissing D., Poulsen B., Jaattela M. Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. J Biol Chem. 277:2002;39499-39506.
113. Fontana J., Fulton D., Chen Y., Fairchild T.A., McCabe T.J., Fujita N., Tsuruo T., Sessa W.C. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res. 90:2002;866-873.
114. Frisch S.M. Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis. Curr Biol. 9:1999;1047-1049.
115. Frisch S.M., Screaton R.A. Anoikis mechanisms. Curr Opin Cell Biol. 13:2001;555-562.
116. Frydman J., Höhfeld J. Chaperones get in touch: the Hip-Hop connection. Trends Biochem Sci. 22:1997;87-92.
117. Fujita N., Sato S., Ishida A., Tsuruo T. Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 277:2002;10346-10353.
118. Fukuda A., Osawa T., Oda H., Tanaka T., Toyokuni S., Uchida K. Oxidative stress response in iron-induced acute nephrotoxicity: enhanced expression of heat shock protein 90. Biochem Biophys Res Commun. 219:1996;76-81.
119. Furutani M., Arii S., Mizumoto M., Kato M., Imamura M. Identification of a neutrophil gelatinase-associated lipocalin mRNA in human pancreatic cancers using a modified signal sequence trap method. Cancer Lett. 122:1998;209-214.
120. Gabai V.L., Meriin A.B., Mosser D.D., Caron A.W., Rits S., Shifrin V.I., Sherman M.Y. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem. 272:1997;18033-18037.
121. Gabai V.L., Yaglom J.A., Volloch V., Meriin A.B., Force T., Koutroumanis M., Massie B., Mosser D.D., Sherman M.Y. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol. 20:2000;6826-6836.
122. Gabai V.L., Mabuchi K., Mosser D.D., Sherman M.Y. Hsp72 and stress kinase c-jun N-terminal kinase regulate the Bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol. 22:2002;3415-3424.
123. Galea-Lauri J., Richardson A.J., Latchman D.S., Katz D.R. Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-α and cycloheximide: a possible role in immunopathology. J Immunol. 157:1996;4109-4118.
124. Gao Y., Thomas J.O., Chow R.L., Lee G.-H., Cowan N.J. A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell. 69:1992;1043-1050.
125. Garcia-Cardena G., Fan R., Shah V., Sorrentino R., Cirino G., Papapetropoulos A., Sessa W.C. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 392:1998;821-824.
126. Garrido C., Fromentin A., Bonnotte B., Favre N., Moutet M., Arrigo A.-P., Mehlen P., Solary E. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cells. Cancer Res. 58:1998;5495-5499.
127. Garrido C., Bruey J.M., Fromentin A., Hammann A., Arrigo A.P., Solary E. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J. 13:1999;2061-2070.
128. Gebhardt B.R., Ries J., Caspary W.F., Boehles H., Stein J. Superoxide: a major factor for stress protein induction in reoxygenation injury in the intestinal cell line Caco-2. Digestion. 60:1999;238-245.
129. Geum D., Son G.H., Kim K. Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells. J Biol Chem. 277:2002;19913-19921.
130. Ghavami A., Nutt M.P., Hardy S.P. Heat shock protein and high-dose aspirin: effects on random skin flap survival in a rat model. Ann Plast Surg. 48:2002;60-67.
131. Goll D.E., Thompson V.F., Li H., Wei W., Cong J. The calpain system. Physiol Rev. 83:2003;731-801.
132. Gorman A.M., Heavey G., Creagh E.M., Cotter T.G., Samali A. Antioxidant mediated inhibition of the heat shock response leads to apoptosis. FEBS Lett. 445:1999;98-102.
133. Gotoh T., Terada K., Mori M. hsp70-DnaJ chaperone pairs prevent nitric oxide-mediated apoptosis in RAW 264.7 macrophages. Cell Death Differ. 8:2001;357-366.
134. L prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 20:2000;5680-5689.
135. Gronbaek K., Straten P.T., Ralfkiaer E., Ahrenkiel V., Andersen M.K., Hansen N.E., Zeuthen J., Hou-Jensen K., Guldberg P. Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity. Blood. 92:1998;3018-3024.
136. Gross A., McDonnell J.M., Korsmeyer S.J. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1999;1899-1911.
137. Gross C., Koelch W., DeMaio A., Arispe N., Multhoff G. Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem. 278:2003;41173-41181.
138. Grossmann J. Molecular mechanisms of "detachment-induced apoptosis - anoikis" Apoptosis. 7:2002;247-260.
139. Grotzer M.A., Eggert A., Zuzak T.J., Janss A.J., Marwaha S., Wiewrodt B.R., Ikegaki N., Brodeur G.M., Phillips P.C. Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression. Oncogene. 19:2000;4604-4610.
140. Haendeler J., Hoffmann J., Rahman S., Zeiher A.M., Dimmeler S. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett. 536:2003;180-186.
141. Hargitai J., Lewis H., Boros I., Rácz T., Fiser A., Kurucz I., Benjamin I., Pénzes Z., Vígh L., Csermely P., Latchman D.S. Bimoclomol, a heat shock protein co-inducer acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun. 307:2003;689-695.
142. Hargreaves R., David C.L., Whitesell L., Skibo E.B. Design of quinolenedione-based geldanamycin analogues. Bioorg Med Chem Lett. 13:2003;3075-3078.
143. Hartl F.U. Molecular chaperones in cellular protein folding. Nature. 381:1996;571-579.
144. Hartl F.U., Hartl H. Molecular chaperones in the cytosol: from nascent chain to folded proteins. Science. 295:2002;1852-1858.
145. Hatayama T., Yamagishi N., Minobe E., Sakai K. Role of hsp105 in protection against stress-induced apoptosis in neuronal PC12 cells. Biochem Biophys Res Commun. 288:2001;528-534.
146. Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp Cell Res. 25:1961;585-621.
147. Helmbrecht K., Zeise E., Rensing L. Chaperones in cell cycle regulation and mitogenic signal transduction: a review. Cell Prolif. 33:2000;341-365.
148. Henshall D.C., Araki T., Schindler C.K., Lan J.Q., Tiekoter K.L., Taki W., Simon R.P. Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J Neurosci. 22:2002;8458-8465.
149. Hoehn B., Ringer T.M., Xu L., Giffard R.G., Sapolsky R.M., Steinberg G.K., Yenari M.A. Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab. 21:2001;1303-1309.
150. Höhfeld J. Regulation of the heat shock conjugate Hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights. Biol Chem. 379:1998;269-274.
151. Höhfeld J., Jentsch S. GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16:1997;6209-6216.
152. Höhfeld J., Minami Y., Hartl F.U. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Cell. 83:1995;589-598.
153. Holt S.E., Aisner D.L., Baur J., Tesmer V.M., Dy M., Ouellette M., Trager J.B., Morin G.B., Toft D.O., Shay J.W., Wright W.E., White M.A. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13:1999;817-826.
154. Hostein I., Robertson D., DiStefano F., Workman P., Clarke P.A. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61:2001;4003-4009.
155. House S.D., Guidon P.T. Jr., Perdrizet G.A., Rewinski M., Kyriakos R., Bockman R.S., Mistry T., Gallagher R.A., Hightower L.E. Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response. Cell Stress Chaperones. 6:2001;164-171.
156. Hu W., Feng Z., Eveleigh J., Iyer G., Pan J., Amin S., Chung F.L., Tang M.S. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis. 23:2002;1781-1789.
157. Huang S., Ingber D.E. Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp Cell Res. 261:2000;91-103.
158. Hulkko S.M., Wakui H., Zilliacus J. The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function. Biochem J. 349:2000;885-893.
159. Hung W.J., Roberson R.S., Taft J., Wu D.Y. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. Mol Cell Biol. 23:2003;3477-3486.
160. Huot J., Houle F., Rousseau S., Deschesnes R.G., Shah G.M., Landry J. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis. J Cell Biol. 143:1998;1361-1373.
161. Ikeyama S., Kusumoto K., Miyake H., Rokutan K., Tashiro S. A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol. J Hepatol. 35:2001;53-61.
162. Ishihara K., Yamagishi N., Saito Y., Adachi H., Kobayashi Y., Sobue G., Ohtsuka K., Hatayama T. Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity. J Biol Chem. 278:2003;25143-25150.
163. Itoh H., Komatsuda A., Wakui H., Miura A.B., Tashima Y. Mammalian Hsp60 is a major target for the immunosuppressant mizoribine. J Biol Chem. 274:1999;35147-35151.
164. Itoh H., Ogura M., Komatsuda A., Wakui H., Miura A.B., Tashima Y. A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90. Biochem J. 343:1999;697-703.
165. 2: role of thioredoxin. Biochem J. 318:1996;187-193.
166. Johnson J., Corbisier R., Stensgard B., Toft D. The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes. J Steroid Biochem Mol Biol. 56:1996;31-37.
167. Johnson H., Scorrano L., Korsmeyer S.J., Ley T.J. Cell death induced by granzyme C. Blood. 101:2003;3093-3101.
168. Jolly C., Morimoto R.I. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Res Inst. 92:2000;1564-1572.
169. Jurivich D.A., Sistonen L., Kroes R.A., Morimoto R.I. Effect of sodium salicylate on the human heat shock response. Science. 255:1992;1243-1245.
170. Kagedal K., Johansson U., Ollinger K. The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress. FASEB J. 15:2001;1592-1594.
171. Kageyama K., Ihara Y., Goto S., Urata Y., Toda G., Yano K., Kondo T. Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells. J Biol Chem. 277:2002;19255-19264.
172. Kalmar B., Burnstock G., Vrbova G., Urbanics R., Csermely P., Greensmith L. Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats. Exp Neurol. 176:2002;87-97.
173. Kamal A., Thao L., Sensintaffar J., Zhang L., Boehm M.F., Fritz L.C., Burrows F.J. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 425:2003;407-410.
174. Kamradt M.C., Chen F., Sam S., Cryns V.L. The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. J Biol Chem. 277:2002;38731-38736.
175. Kato K., Ito H., Okamoto K. Modulation of the arsenite-induced expression of stress proteins by reducing agents. Cell Stress Chaperones. 2:1997;199-209.
176. Kato K., Yamanaka K., Hasegawa A., Okada S. Dimethylarsinic acid exposure causes accumulation of Hsp72 in cell nuclei, and suppresses apoptosis in human alveolar cultured (L-132) cells. Biol Pharm Bull. 22:1999;1185-1188.
177. Kaufman R.J. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13:1999;1211-1233.
178. Kawamura H., Otsuka T., Matsuno H., Niwa M., Matsui N., Kato K., Uematsu T. Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 kinases. Am J Physiol. 277:1999;E1046-E1054.
179. Kelland L.R., Sharp S.Y., Rogers P.M., Myers T.G., Workman P. DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst. 91:1999;1940-1949.
180. Kellermayer M.S.Z., Csermely P. ATP induces dissociation of the 90 kDa heat shock protein (hsp90) from F-actin: interference with the binding of heavy meromyosin. Biochem Biophys Res Commun. 211:1995;166-174.
181. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:1972;239-257.
182. Kim D., Li G.C. Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression. Biochem Biophys Res Commun. 264:1999;352-358.
183. Kim D., Kim S.H., Li G.C. Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression. Biochem Biophys Res Commun. 254:1999;264-268.
184. Kim H.R., Kang H.S., Kim H.D. Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells. IUBMB Life. 48:1999;429-433.
185. Kimura C., Zhao Q.L., Kondo T., Amatsu M., Fujiwara Y. Mechanism of UV-induced apoptosis in human leukemia cells: roles of Ca2+/Mg(2+)-dependent endonuclease, caspase-3, and stress-activated protein kinases. Exp Cell Res. 239:1998;411-422.
186. Kirchhoff S.R., Gupta S., Knowlton A.A. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 105:2002;2899-2904.
187. Klein S.D., Brune B. Heat shock protein 70 attenuates nitric oxide induced apoptosis in RAW macrophages by preventing cytochrome c release. Biochem J. 362:2002;635-641.
188. Ko H.S., Uehara T., Nomura Y. Role of ubiquitin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. J Biol Chem. 277:2002;35386-35392.
189. Kobayashi Y., Kume A., Li M., Doyu M., Hata M., Ohtsuka K., Sobue G. Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem. 275:2000;8772-8778.
190. Komatsuda A., Wakui H., Ohtani H., Imai H., Miura A.B., Itoh H. Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis. Pathol Int. 49:1999;513-518.
191. Kondo T., Matsuda T., Tashima M., Umehara H., Domae N., Yokoyama K., Uchiyama T., Okazaki T. Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. J Biol Chem. 275:2000;8872-8879.
192. Konishi A., Shimizu S., Hirota J., Takao T., Fan Y., Matsuoka Y., Zhang L., Yoneda Y., Fujii Y., Skoultchi A.L., Tsujimoto Y. Involvement of histone H1.2 in apoptosis induced by DNA strand breaks. Cell. 114:2003;673-688.
193. Konno A., Sato N., Yagihashi A., Torigoe T., Cho J.M., Torimoto K., Hara I., Wada Y., Okubo M., Takahashi N. Heat-, or stress-inducible transformation-associated cell surface antigen on the activated H-ras oncogene-transfected rat fibroblast. Cancer Res. 49:1989;6578-6582.
194. Koonin E.V., Aravind L. Origin and evolution of eukaryotic apoptosis: the bacterial connection. Cell Death Differ. 9:2002;394-404.
195. Koyasu S., Nishida E., Kadowaki T., Matsuzaki F., Iida K., Harada F., Kasuga M., Sakai H., Yahara I. Two mammalian heat shock proteins, Hsp90 and Hsp100 are actin-binding proteins. Proc Natl Acad Sci USA. 83:1986;8054-8058.
196. Krtolica A., Parrinello S., Lockett S., Desprez P.-Y., Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA. 98:2001;12072-12077.
197. Kuduk S.D., Zheng F.F., Sepp-Lorenzino L., Rosen N., Danishefsky S.J. Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett. 9:1999;1233-1238.
198. Kuduk S.D., Harris T.C., Zheng F.F., Sepp-Lorenzino L., Ouerfelli Q., Rosen N., Danishefsky S.J. Synthesis and evaluation of geldanamycin- testosterone hybrids. Bioorg Med Chem Lett. 10:2000;1303-1306.
199. Kuroita T., Tachibana H., Ohashi H., Shirahata S., Murakami H. Growth stimulating activity of heat shock protein 90 a to lymphoid cell lines in serum-free medium. Cytotechnology. 8:1992;109-117.
200. Kurthy M., Mogyorosi T., Nagy K., Kukorelli T., Jednakovits A., Talosi L., Biro K. Effect of BRX-220 against peripheral neuropathy and insulin resistance in diabetic rat models. Ann NY Acad Sci. 967:2002;482-489.
201. Lam K.T., Calderwood S.K. hsp70 binds specifically to a peptide derived from the highly conserved domain (I) region of p53. Biochem Biophys Res Commun. 184:1992;167-174.
202. Lässle M., Blatch G.L., Kundra V., Takatori T., Zetter B.R. Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases. J Biol Chem. 272:1997;1876-1884.
203. Lavrentiadou S.N., Chan C., Kawcak T., Ravid T., Tsaba A., van der Vliet A., Rasooly R., Goldkorn T. Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione. Am J Respir Cell Mol Biol. 25:2001;676-684.
204. Lawen A. Apoptosis - an introduction. BioEssays. 25:2003;888-896.
205. Lee M.W., Park S.C., Chae H.S., Bach J.H., Lee H.J., Lee S.H., Kang Y.K., Kim K.Y., Lee W.B., Kim S.S. The protective role of Hsp90 against 3-hydroxykynurenine-induced neuronal apoptosis. Biochem Biophys Res Commun. 284:2001;261-267.
206. Lewis K. Programmed death in bacteria. Microbiol Mol Biol Rev. 64:2000;503-514.
207. Lewis J., Devin A., Miller A., Lin Y., Rodriguez Y., Neckers L., Liu Z.G. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J Biol Chem. 275:2000;10519-10526.
208. Li Z., Menoret A., Srivastava P. Roles of heat shock proteins in antigen presentation and cross-presentation. Curr Opin Immunol. 14:2002;45-51.
209. Lindquist S., Craig E.A. The heat-shock proteins. Annu Rev Genet. 22:1988;631-677.
210. Liossis S.N., Ding X.Z., Kiang J.G., Tsokos G.C. Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells. J Immunol. 158:1997;5668-5675.
211. Liu H., Bowes R.C. III, van de Water B., Sillence C., Nagelkerke J.F., Stevens J.L. Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells. J Biol Chem. 272:1997;21751-21759.
212. Liu X., Zou H., Slaughter C., Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89:1997;175-184.
213. Liu N., Raja S.M., Zazzeroni F., Metkar S.S., Shah R., Zhang M., Wang Y., Bromme D., Russin W.A., Lee J.C., Peter M.E., Froelich C.J., Franzoso G., Ashton-Rickardt P.G. NF-κB protects from the lysosomal pathway of cell death. EMBO J. 22:2003;5313-5322.
214. Lorand L., Graham R.L. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol. 4:2003;140-156.
215. Mandic A., Viktorsson K., Strandberg L., Heiden T., Hansson J., Linder S., Shoshan M.C. Calpain-mediated bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol. 22:2002;3003-3013.
216. Mandic A., Hansson J., Linder S., Shoshan M.C. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem. 278:2003;9100-9106.
217. Marcu M.G., Chadli A., Bouhouche I., Catelli M., Neckers L.M. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem. 275:2000;37181-37186.
218. Margulis B.A., Welsh M. Isolation of Hsp70-binding proteins from bovine muscle. Biochim Biophys Res Commun. 178:1991;1-7.
219. Martin S.J., Reutelingsperger C.P., McGahon A.J., Rader J.A., van Schie R.C., LaFace D.M., Green D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med. 182:1995;1545-1556.
220. Martinou J.C., Desagher B., Antonsson B. Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol. 2:2000;E41-E43.
221. Mathiasen I.S., Jaattela M. Triggering caspase-independent cell death to combat cancer. Trends Mol Med. 8:2002;212-220.
222. Mathiasen I.S., Sergeev I.N., Bastholm L., Elling F., Norman A.W., Jaattela M. Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem. 277:2002;30738-30745.
223. Matsumoto A., Comatas K.E., Liu L., Stamler J.S. Screening for nitric oxide-dependent protein-protein interactions. Science. 301:2003;657-661.
224. Maulik N., Engelman R.M., Wei Z., Liu X., Rousou J.A., Flack J.E., Deaton D.W., Das D.K. Drug-induced heat-shock preconditioning improves postischemic ventricular recovery after cardiopulmonary bypass. Circulation. 92:1995;381-388.
225. Mayer B., Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci. 22:1997;477-481.
226. Mearow K.M., Dodge M.E., Rahimtula M., Yegappan C. Stress-mediated signaling in PC12 cells - the role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal. J Neurochem. 83:2002;452-462.
227. Menoret A., Li Z., Niswonger M.L., Altmeyer A., Srivastava P.K. An endoplasmic reticulum protein implicated in chaperoning peptides to major histocompatibility of class I is an aminopeptidase. J Biol Chem. 276:2001;33313-33318.
228. Meriin A.B., Gabai V.L., Yaglom J., Shifrin V.I., Sherman M.Y. Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J Biol Chem. 273:1998;6373-6379.
229. Metkar S.S., Wang B., Ebbs M.L., Kim J.H., Lee Y.J., Raja S.M., Froelich C.J. Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol. 160:2003;875-885.
230. Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 114:2003;181-190.
231. Montague J.W., Gaido M.L., Frye C., Cidlowski J.A. A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity. J Biol Chem. 269:1994;18877-18880.
232. Montague J.W., Hughes F.M. Jr., Cidlowski J.A. Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis. J Biol Chem. 272:1997;6677-6684.
233. Morimoto R.I. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 12:1998;3788-3796.
234. Morimoto R.I. Dynamic remodeling of transcription complexes by molecular chaperones. Cell. 110:2002;281-284.
235. Morimoto R.I., Sarge K.D., Abravaya K. Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. J Biol Chem. 269:1992;21987-21990.
236. Morimoto R.I., Tisseres A., Georgopoulos C. Heat Shock Proteins in Biology and Medicine. 1994;Cold Spring Harbor Press, Cold Spring Harbor, NY.
237. Moser C., Schmidbauer C., Gurtler U., Gross C., Gehrmann M., Thonigs G., Pfister K., Multhoff G. Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells. Cell Stress Chaperones. 7:2002;365-373.
238. Mosser D.D., Caron A.W., Bourget L., Denis-Larose C., Massie B. Role of the human heat shock protein 70 in protection against stress-induced apoptosis. Mol Cell Biol. 17:1997;5317-5327.
239. Mosser D.D., Caron A.W., Bourget L., Meriin A.B., Sherman M.Y., Morimoto R.I., Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 20:2000;7146-7159.
240. Movsesyan V.A., Yakovlev A.G., Dabaghyan E.A., Stoica B.A., Faden A.L. Ceramide induces neuronal apoptosis through caspase-9/capase-3 pathway. Biochem Biophys Res Commun. 299:2002;201-207.
241. Multhoff G. Activation of natural killer cells by heat shock protein 70. Int J Hypertherm. 18:2002;576-585.
242. Multhoff G., Hightower L.E. Cell surface expression of heat shock proteins and the immune response. Cell Stress Chaperones. 1:1996;167-176.
243. Multhoff G., Botzler C., Wiesnet M., Muller E., Meier T., Wilmanns W., Issels R.D. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer. 61:1995;272-279.
244. Multhoff G., Botzler C., Jennen L., Schmidt J., Ellwart J., Issels R. Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells. J Immunol. 158:1997;4341-4350.
245. Munster P.N., Basso A., Solit D., Norton L., Rosen N. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin Cancer Res. 7:2001;2228-2236.
246. Munster P.N., Marchion D.C., Basso A.D., Rosen N. Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-AKT-dependent pathway. Cancer Res. 62:2002;3132-3137.
247. Nadeau K., Nadler S.G., Saulnier M., Tepper M.A., Walsh C.T. Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. Biochemistry. 33:1994;2561-2567.
248. Nadler S.G., Tepper M.A., Schacter B., Mazzucco C.E. Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. Science. 258:1992;484-486.
249. Nagayama S., Jono H., Suzaki H., Sakai K., Tsuruya E., Yamatsu I., Isohama Y., Miyata T., Kai H. Carbenoxolone, a new inducer of heat shock protein 70. Life Sci. 69:2001;2867-2873.
250. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Capase-12 mediates endoplasmic reticulum specific apoptosis and cytotoxicity by amyloid-β Nature. 403:2000;98-103.
251. Nanasi P.P., Jednakovits A. Multilateral in vivo and in vitro protective effects of the novel heat shock protein co-inducer, bimoclomol: results of preclinical studies. Cardiovasc Drug Rev. 19:2001;133-151.
252. Nardai G., Sass B., Eber J., Orosz Gy., Csermely P. Reactive cysteines of the 90-kDa heat shock protein, Hsp90. Arch Biochem Biophys. 384:2000;59-67.
253. Nardai G., Csermely P., Soti C. Chaperone function and chaperone overload in the aged. Exp Gerontol. 37:2002;1257-1262.
254. Natsuka S., Takubo R., Seki R., Ikura K. Molecular cloning and expression of Caenorhabditis elegans ERp57-homologue with transglutaminase activity. J Biochem (Tokyo). 130:2001;731-735.
255. Neckers L. Heat shock protein 90 inhibition by 17-allylamino-17- demethoxygeldanamycin: a novel therapeutic approach for treating hormone-refractory prostate cancer. Clin Cancer Res. 8:2002;962-966.
256. Neckers L., Lee Y.-S. The rules of attraction. Nature. 425:2003;357-358.
257. Neckers L., Mimnaugh E., Schulte T.W. Hsp90 as an anti-cancer target. Drug Resist Updat. 2:1999;165-172.
258. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trends Biochem Sci. 22:1997;299-306.
259. Nollen E.A., Brunsting J.F., Song J., Kampinga H.H., Morimoto R.I. Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol. 20:2000;1083-1088.
260. Nylandsted J., Rohde M., Brand K., Bastholm L., Elling F., Jaattela M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci USA. 97:2000;7871-7876.
261. Nylandsted J., Wick W., Hirt U.A., Brand K., Rohde M., Leist M., Weller M., Jaattela M. Eradication of glioblastoma, and breast colon carcinoma xenografts by Hsp70 depletion. Cancer Res. 62:2002;7139-7142.
262. Oliverio S., Amendola A., Rodolfo C., Spinedi A., Piacentini M. Inhibition of "tissue" transglutaminase increases cell survival by preventing apoptosis. J Biol Chem. 274:1999;34123-34128.
263. Pandey P., Saleh A., Nakazawa A., Kumar S., Srinivasula S.M., Kumar V., Weichselbaum R., Nalin C., Alnemri E.S., Kufe D., Kharbanda S. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 19:2000;4310-4322.
264. Papp E., Nardai G., Soti Cs., Csermely P. Molecular chaperones, stress proteins and redox homeostasis. Biofactors. 17:2003;249-257.
265. Pardo J., Balkow S., Anel A., Simon M.M. Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control. Eur J Immunol. 32:2002;2881-2887.
266. Park Y.M., Han M.Y., Blackburn R.V., Lee Y.J. Overexpression of HSP25 reduces the level of TNF alpha-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells. J Cell Physiol. 174:1998;27-34.
267. Park H.S., Lee J.S., Huh S.H., Seo J.S., Choi E.J. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J. 20:2001;446-456.
268. Park H.S., Cho S.G., Kim C.K., Hwang H.S., Noh K.T., Kim M.S., Huh S.H., Kim M.J., Ryoo K., Kim E.K., Kang W.J., Lee J.S., Seo J.S., Ko Y.G., Kim S., Choi E.J. Heat shock protein hsp72 is a negative regulator of apoptosis signal regulating kinase 1. Mol Cell Biol. 22:2002;7721-7730.
269. Patil C., Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol. 13:2001;349-355.
270. Pato B., Mihály K., Csermely P. Chaperones and cytoarchitecture: geldanamycin induces an accelerated efflux of cytoplasmic proteins from detergent-treated cells. Eur J Biochem. 268:2001;S107.
271. Paul C., Manero F., Gonin S., Kretz-Remy C., Virot S., Arrigo A.P. Hsp27 as a negative regulator of cytochrome c release. Mol Cell Biol. 22:2002;816-834.
272. Pawelec G., Barnett Y., Forsey R., Frasca D., Globerson A., McLeod J., Caruso C., Franceschi C., Fulop T., Gupta S., Mariani E., Mocchegiani E., Solana R. T cells and aging, January 2002 update. Front Biosci. 7:2002;D1056-D1183.
273. Pechan P.M. Heat shock proteins and cell proliferation. FEBS Lett. 280:1991;1-4.
274. Perdrizet G.A., Kaneko H., Buckley T.M., Fishman M.S., Pleau M., Bow L., Schweizer R.T. Heat shock recovery protects renal allografts from warm ischemic injury and enhances HSP72 production. Transplant Proc. 25:1993;1670-1673.
275. Pettus B.J., Chalfant C.E., Hannun Y.A. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 1585:2002;114-125.
276. Piacentini M., Farrace M.G., Pieredda L., Matarrese P., Ciccosanti F., Falasca L., Rodolfo C., Giammarioli A.M., Verderio E., Griffin M., Malorni W. Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress. J Neurochem. 81:2002;1061-1072.
277. Piatelli M.J., Doughty C., Chiles T.C. Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. J Biol Chem. 277:2002;12144-12150.
278. Polanowska-Grabowska R., Gear A.R. Heat-shock proteins and platelet function. Platelets. 11:2000;16-22.
279. Poppe M., Reimertz C., Munstermann G., Kogel D., Prehn J.H.M. Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. J Neurochem. 82:2002;482-494.
280. Powell J.K., Young K.D. Lysis of Escherichia coli by beta-lactams which bind penicillin-binding proteins 1a and 1b: inhibition by heat shock proteins. J Bacteriol. 173:1991;4021-4026.
281. Pratt W.B. The role of the Hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. Annu Rev Pharmacol Toxicol. 37:1997;297-326.
282. Pratt W.B., Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med. 228:2003;111-133.
283. Preville X., Salvemini F., Giraud S., Chaufour S., Paul C., Stepien G., Ursini M.V., Arrigo A.P. Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery. Exp Cell Res. 247:1999;61-78.
284. Pritchard K.A. Jr., Ackerman A.W., Gross E.R., Stepp D.W., Shi Y., Fontana J.T., Baker J.E., Sessa W.C. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem. 276:2001;17621-17624.
285. Proskuryakov S.Y., Konoplyannikov A.G., Gabai V.L. Necrosis: a specific form of programmed cell death? Exp Cell Res. 283:2003;1-16.
286. Punyiczki M., Fesus L. Heat shock and apoptosis. The two defense systems of the organism may have overlapping molecular elements. Ann NY Acad Sci. 851:1998;67-74.
287. Queitsch C., Sangster T.A., Lindquist S. Hsp90 as a capacitor of phenotypic variation. Nature. 417:2002;618-624.
288. Raja S.M., Metkar S.S., Froelich C.J. Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol. 15:2003;528-532.
289. Rane M.J., Pan Y., Singh S., Powell D.W., Wu R., Cummins T., Chen Q., McLeish K.R., Klein J.B. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 278:2003;27828-27835.
290. Rao R.V., Peel A., Logvinova A., del Rio G., Hermel E., Yokota T., Goldsmith P.C., Ellerby L.M., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 514:2002;122-128.
291. Rathmell J.C., Thompson C.B. The central effectors of cell death in the immune system. Annu Rev Immunol. 17:1999;781-828.
292. Ravagnan L., Gurbuxani S., Susin S.A., Maisse C., Daugas E., Zamzami N., Mak T., Jaattela M., Penninger J.M., Garrido C., Kroemer G. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 3:2001;839-843.
293. Reddy R.K., Lu J., Lee A.S. The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis. J Biol Chem. 274:1999;28476-28483.
294. Reddy R.K., Mao C., Baumeister P., Austin R.C., Kaufman R.J., Lee A.S. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem. 278:2003;20915-20924.
295. 2+-dependent endonuclease from human spleen: purification, properties, and role in apoptosis. Biochemistry. 32:1993;9129-9136.
296. Richter K., Buchner J. Hsp90: chaperoning signal transduction. J Cell Physiol. 188:2001;281-290.
297. Ritossa F. A new puffing pattern induced by heat shock and DNP in Drosophila. Experientia. 18:1962;571-573.
298. Roe S.M., Prodromou C., O'Brien R., Ladbury J.E., Piper P.W., Pearl L.H. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem. 42:1999;260-266.
299. Rossig L., Fichtlscherer B., Breitschopf K., Haendeler J., Zeiher A.M., Mulsch A., Dimmeler S. Nitric oxide inhibits caspase-3 by S-nitrosylation in vivo. J Biol Chem. 274:1999;6823-6826.
300. Rothe M., Wong S.C., Henzel W.J., Goeddel D.V. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 78:1994;681-692.
301. Rothe M., Sarma V., Dixit V.M., Goeddel D.V. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science. 269:1995;1424-1427.
302. Rufini A., Testi R. Lipid signaling in CD95-mediated apoptosis. Subcell Biochem. 36:2000;285-308.
303. Rutherford S.L., Lindquist S. Hsp90 as a capacitor for morphological evolution. Nature. 396:1998;336-342.
304. Ruvolo P.P., Clark W., Mumby M., Gao F., May W.S. A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl-2 phosphorylation status and function. J Biol Chem. 277:2002;22847-22852.
305. Sachidhanandam S.B., Lu J., Low K.S., Moochhala S.M. Herbimycin A attenuates apoptosis during heat stress in rats. Eur J Pharmacol. 474:2003;121-128.
306. Saibil H. Molecular chaperones: containers and surfaces for folding, stabilizing or unfolding proteins. Curr Opin Struct Biol. 10:2000;251-258.
307. Saito Y., Yamagishi N., Ishihara K., Hatayama T. Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system. Exp Cell Res. 286:2003;233-240.
308. Sakahira H., Nagata S. Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase. J Biol Chem. 277:2002;3364-3370.
309. Sakamoto H., Mashima T., Yamamoto K., Tsuruo T. Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification. J Biol Chem. 277:2002;45770-45775.
310. Samali A., Orrenius S. Heat shock proteins: regulators of stress response and apoptosis. Cell Stress Chaperones. 3:1998;228-236.
311. Samali A., Cai J., Zhivotovsky B., Jones D.P., Orrenius S. Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells. EMBO J. 18:1999;2040-2048.
312. Samali A., Robertson J.D., Peterson E., Manero F., van Zeijl L., Paul C., Cotgreave I.A., Arrigo A.P., Orrenius S. Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli. Cell Stress Chaperones. 6:2001;49-58.
313. Sano M. Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons. Neuropharmacology. 40:2001;947-953.
314. Sapozhnikov A.M., Gusarova G.A., Ponomarev E.D., Telford W.G. Translocation of cytoplasmic HSP70 onto the surface of EL-4 cells during apoptosis. Cell Prolif. 35:2002;193-206.
315. Sato S., Fujita N., Tsuruo T. Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA. 97:2000;10832-10837.
316. Sausville E.A. Combining cytotoxics and 17-allylamino, 17-demethoxy-geldanamycin: sequence and tumor biology matters. Clin Cancer Res. 7:2001;2155-2158.
317. Scharf K.D., Höhfeld I., Nover L. Heat stress response and heat stress transcription factors. J Biosci. 23:1998;313-329.
318. Schett G., Steiner C.W., Groger M., Winkler S., Graninger W., Smolen J., Xu Q., Steiner G. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70. FASEB J. 13:1999;833-842.
319. Schild H., Rammensee H.G. gp96 - the immune system's Swiss army knife. Nat Immunol. 1:2000;100-101.
320. Schliwa M., van Blerkom J., Porter K.R. Stabilization of the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. Proc Natl Acad Sci USA. 78:1981;4329-4333.
321. Schnaider T., Oikarinen J., Ishiwatari-Hayasaka H., Yahara I., Csermely P. Interactions of Hsp90 with histones and related peptides. Life Sci. 65:1999;2417-2426.
322. Schoeniger L.O., Andreoni K.A., Ott G.R., Risby T.H., Bulkley G.B., Udelsman R., Burdick J.F., Buchman T.G. Induction of heat shock gene expression in the postischemic pig liver depends upon superoxide generation at reperfusion. Gastroenterology. 106:1994;177-184.
323. Schulte T.W., Neckers L.M. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol. 42:1998;273-279.
324. Schulte T.W., An W.G., Neckers L.M. Geldanamycin-induced destabilization of Raf-1 involves the proteasome. Biochem Biophys Res Commun. 239:1997;655-659.
325. Schulte T.W., Akinaga S., Murakata T., Agatsuma T., Sugimoto S., Nakano H., Lee Y.S., Simen B.B., Argon Y., Felts S., Toft D.O., Neckers L.M., Sharma S.V. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol Endocrinol. 13:1999;1435-1448.
326. Schwarze S.R., Fu V.X., Jarrard D.F. Cdc37 enhances proliferation and is necessary for normal human prostate epithelial cell survival. Cancer Res. 63:2003;4614-4619.
327. Seluanov A., Gorbunova V., Falcovitz A., Sigal A., Milyavksy M., Zurer I., Shohat G., Goldfinger N., Rotter V. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol Cell Biol. 21:2001;1552-1564.
328. Sepehrnia B., Paz I.B., Dasgupta G., Momand J. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. J Biol Chem. 271:1996;15084-15090.
329. Shchors K., Yehiely F., Kular R.K., Kotlo K.U., Brewer G., Deiss L.P. Cell death inhibiting RNA (CDIR) derived from a 3′-untranslated region binds AUF1 and heat shock protein 27. J Biol Chem. 277:2002;47061-47072.
330. Shibata M., Hattori H., Sasaki T., Gotoh J., Hamada J., Fukuuchi Y. Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion. NeuroReport. 13:2002;1985-1988.
331. Shiotsu Y., Neckers L.M., Wortman I., An W.G., Schulte T.W., Soga S., Murakata C., Tamaoki T., Akinaga S. Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Blood. 96:2000;2284-2291.
332. Shivapurkar N., Reddy J., Chaudhary P.M., Gazdar A.F. Apoptosis and lung cancer: a review. J Cell Biochem. 88:2003;885-898.
333. Sittler A., Lurz R., Lueder G., Priller J., Lehrach H., Hayer-Hartl M.K., Hartl F.U., Wanker E.E. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet. 10:2001;1307-1315.
334. Smith J.R., Pereira-Smith O.M. Replicative senescence: implications for in vivo aging and tumor suppression. Science. 273:1996;63-67.
335. Soga S., Kozawa T., Narumi H., Akinaga S., Irie K., Matsumoto K., Sharma S.V., Nakano H., Mizukami T., Hara M. Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway. J Biol Chem. 273:1998;822-828.
336. Solit D.B., Zheng F.F., Drobnjak M., Munster P.N., Higgins B., Verbel D., Heller G., Tong W., Cordon-Cardo C., Agus D.B., Scher H.I., Rosen N. 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res. 8:2002;986-993.
337. Sollars V., Lu X., Xiao L., Wang X., Garfinkel M.D., Ruden D.M. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet. 33:2003;70-74.
338. Song H.Y., Dunbar J.D., Zhang Y.X., Guo D., Donner D.B. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. J Biol Chem. 270:1995;3574-3581.
339. Song J., Takeda M., Morimoto R.I. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol. 3:2001;276-282.
340. Song Y., Cardounel A.J., Zweier J.L., Xia Y. Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation. Biochemistry. 41:2002;10616-10622.
341. Soti Cs., Csermely P. Molecular chaperones in the etiology and therapy of cancer. Pathol Oncol Res. 4:1998;316-321.
342. Soti Cs., Csermely P. Chaperones and the ageing process. Biogerontology. 1:2000;225-233.
343. Soti Cs., Csermely P. Chaperones and aging: their role in neurodegeneration and other civilizational diseases. Neurochem Int. 41:2002;383-389.
344. Soti C., Racz A., Csermely P. A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket. J Biol Chem. 277:2002;7066-7075.
345. Soti C., Sreedhar A.S., Csermely P. Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch. Aging Cell. 2:2003;39-45.
346. Soti Cs., Vermes A., Haystead T.A., Csermely P. Comparative analysis of the N- and C-terminal ATP-binding sites of Hsp90: a distinct nucleotide specificity of the C-terminal ATP-binding site. Eur J Biochem. 270:2003;2421-2428.
347. Spee P., Neefjes J. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin. Eur J Immunol. 27:1997;2441-2449.
348. Sreedhar A.S., Pardhasaradhi B.V., Begum Z., Khar A., Srinivas U.K. Lack of heat shock response triggers programmed cell death in a rat histiocytoic cell line. FEBS Lett. 456:1999;339-342.
349. Sreedhar A.S., Pardhasaradhi B.V., Khar A., Srinivas U.K. Heat induced expression of CD95 and its correlation with the activation of apoptosis upon heat shock in rat histiocytic tumor cells. FEBS Lett. 472:2000;271-275.
350. Sreedhar A.S., Pardhasaradhi B.V., Khar A., Srinivas U.K. A cross talk between cellular signalling and cellular redox state during heat-induced apoptosis in a rat histiocytoma. Free Radic Biol Med. 32:2002;221-227.
351. Sreedhar A.S., Pardhasaradhi B.V., Khar A., Srinivas U.K. Effect of C-terminal deletion of p53 on heat induced CD95 expression and apoptosis in a rat histiocytoma. Oncogene. 21:2002;4042-4049.
352. Sreedhar A.S., Mihály K., Pató B., Schnaider T., Steták A., Kis-Petik K., Fidy J., Simonics T., Maráz A., Csermely P. Hsp90 inhibition accelerates cell lysis: anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. J Biol Chem. 278:2003;35231-35240.
353. Sreedhar A.S., Soti C., Csermely P. Inhibition of Hsp90: a new strategy for inhibiting protein kinases. Biochim Biophys Acta. 2003;. (in press).
354. Srivastava P. Heat shock proteins in innate and adaptive immunity. Nat Rev Immunol. 2:2002;185-194.
355. Srivastava P.K., Heike M. Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation? Semin Immunol. 3:1991;57-64.
356. Srivastava P.K., Maki R.G. Stress-induced proteins in immune response to cancer. Curr Top Microbiol Immunol. 167:1991;109-123.
357. Srivastava P.K., DeLeo A.B., Old L.J. Tumor rejection antigens of chemically induced tumors of inbred mice. Proc Natl Acad Sci USA. 83:1986;3407-3411.
358. Srivastava P.K., Udono H., Blachere N.E., Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics. 39:1994;93-98.
359. Stebbins C.E., Russo A.A., Schneider C., Rosen N., Hartl F.U., Pavletich N.P. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell. 89:1997;239-250.
360. Stepanova L., Finegold M., DeMayo F., Schmidt E.V., Harper J.W. The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. Mol Cell Biol. 20:2000;4462-4473.
361. Stepanova L., Yang G., DeMayo F., Wheeler T.M., Finegold M., Thompson T.C., Harper J.W. Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene. 19:2000;2186-2193.
362. Stuart J.K., Myszka D.G., Joss L., Mitchell R.S., McDonald S.M., Xie Z., Takayama S., Reed J.C., Ely K.R. Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones. J Biol Chem. 273:1998;22506-22514.
363. Stubdal H., Zalvide J., Campbell K.S., Schweitzer C., Roberts T.M., DeCaprio J.A. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 17:1997;4979-4990.
364. Stupack D.G., Puente X.S., Boutsaboualoy S., Storgard C.M., Cheresh D.A. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol. 155:2001;459-470.
365. Su C.Y., Chong K.Y., Chen J., Ryter S., Khardori R., Lai C.C. A physiologically relevant hyperthermia selectively activates constitutive hsp70 in H9c2 cardiac myoblasts and confers oxidative protection. J Mol Cell Cardiol. 31:1999;845-855.
366. Supko J.G., Hickman R.L., Grever M.R., Malspeis L. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother Pharmacol. 36:1995;305-315.
367. Sutton V.R., Davis J.E., Cancilla M., Johnstone R.W., Ruefli A.A., Sedelies K., Browne K.A., Trapani J.A. Initiation of apoptosis by granzyme B requires direct cleavage of Bid, but not direct granzyme B-mediated caspase activation. J Exp Med. 192:2000;1403-1414.
368. Suzuki Y.J., Forman H.J., Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med. 22:1997;269-285.
369. Suzuki K., Murtuza B., Sammut I.A., Latif N., Jayakumar J., Smolenski R.T., Kaneda Y., Sawa Y., Matsuda H., Yacoub M.H. Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation. 106:2002;I270-I276.
370. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J.A., Reed J.C. Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-cell death activity. Cell. 80:1995;279-284.
371. Takayama S., Bimston D.N., Matsuzawa S., Freeman B.C., Aime-Sempe C., Xie Z., Morimoto R.I., Reed J.C. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 16:1997;4887-4896.
372. Takuma K., Kiriu M., Mori K., Lee E., Enomoto R., Baba A., Matsuda T. Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes. Neurochem Int. 42:2003;153-159.
373. Terlecky S.R., Chiang H.L., Olson T.S., Dice J.F. Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein. J Biol Chem. 267:1992;9202-9209.
374. Tezel G., Wax M.B. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci. 20:2000;3552-3562.
375. Thannickal V.J., Fanburg B.L. Reactive oxygen species in cell signaling. Am J Physiol. 279:2000;L1005-L1028.
376. Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science. 281:1998;1312-1316.
377. Thress K., Song J., Morimoto R.I., Kornbluth S. Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J. 20:2001;1033-1041.
378. Tomassini B., Testi R. Mitochondria as sensors of sphingolipids. Biochimie. 84:2002;123-129.
379. Török Zs., Tsvetkova N.M., Balogh G., Horváth I., Nagy E., Pénzes Z., Hargitai J., Bensaude O., Csermely P., Crowe J.H., Maresca B., Vígh L. Heat shock protein co-inducers with no effect on protein denaturation specifically modulate the membrane lipid phase. Proc Natl Acad Sci USA. 100:2003;3131-3136.
380. Trapani J.A. Granzyme: a family of lymphocyte granule serine protease. Genome Biol. 2:2001;3014.1-3014.7. (Available at: www.genomebiology.com ).
381. Tucholski J., Johnson G.V. Tissue transglutaminase differentially modulates apoptosis in a stimuli dependent manner. J Neurochem. 81:2002;780-791.
382. Turk B., Stoka V., Rozman-Pungercar J., Cirman T., Droga-Mazovec G., Oreic K., Turk V. Apoptotic pathways: involvement of lysosomal proteases. Biol Chem. 383:2002;1035-1044.
383. Uchiyama Y. Autophagic cell death and its execution by lysosomal cathepsins. Arch Histol Cytol. 64:2001;233-246.
384. Ullrich S.J., Robinson E.A., Law L.W., Willingham M., Appella E. A mouse tumor-specific transplantation antigen is a heat-shock related protein. Proc Natl Acad Sci USA. 83:1986;3121-3125.
385. Urbano A., McCaffrey R., Foss F. Isolation and characterization of NUC70, a cytoplasmic, hematopoietic apoptotic endonuclease. J Biol Chem. 273:1998;34820-34827.
386. van Blitterswijk W.J., van der Luit A.H., Veldman R.J., Verheij M., Borst J. Ceramide: second messenger or modulator of membrane structure and dynamics? Biochem J. 369:2003;199-211.
387. van de Craen M., van den Brande I., Declercq W., Irmler M., Beyaert R., Tschopp J., Fiers W., Vandenabeele P. Cleavage of caspase family members by granzyme B: a comparative study in vitro. Eur J Immunol. 27:1997;1296-1299.
388. vanden Berghe T., Kalai M., van Loo G., Declercq W., Vandenabeele P. Disruption of Hsp90 function reverts tumor necrosis factor-induced necrosis to apoptosis. J Biol Chem. 278:2003;5622-5629.
389. van Loo G., van Gurp M., Depuydt B., Srinivasula S.M., Rodriguez I., Alnemri E.S., Gevaert K., Vandekerckhove J., Declercq W., Vandenabeele P. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 9:2002;20-26.
390. Vasilevskaya I.A., Rakitina T.V., O'Dwyer P.J. Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. Cancer Res. 63:2003;3241-3246.
391. Vaux D.L., Cory S., Adams J.M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 335:1988;440-442.
392. Verheij M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., Kolesnick R.N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 380:1996;75-79.
393. Vigh L., Literati Nagy P., Horvath I., Torok Zs., Balogh G., Glatz A., Kovacs E., Boros I., Ferdinandy P., Farkas B., Jaszlits L., Jednakovits A., Koranyi L., Maresca B. Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med. 3:1997;1150-1154.
394. Wadhwa R., Sugihara T., Yoshida A., Nomura H., Reddel R.R., Simpson R., Maruta H., Kaul S.C. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60:2000;6818-6821.
395. Wang E. Senescent human fibroblasts resist programmed cell death, and failure to suppress Bcl-2 is involved. Cancer Res. 55:1995;2284-2292.
396. Wang G.Q., Wieckowski E., Goldstein L.A., Gastman B.R., Rabinovitz A., Gambotto A., Li S., Fang B., Yin X.M., Rabinowich H. Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med. 194:2001;1325-1337.
397. Warrick J.M., Chan H.Y., Gray-Board G.L., Chai Y., Paulson H.L., Bonini N.M. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet. 23:1999;425-428.
398. Wei Y., Zhao X., Kariya Y., Fukata H., Teshigawara K., Uchida A. Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54:1994;4952-4957.
399. Wei Y.Q., Zhao X., Kariya Y., Teshigawara K., Uchida A. Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells. Cancer Immunol Immunother. 40:1995;73-78.
400. Werneburg N.W., Guicciardi M.E., Bronk S.F., Gores G.J. Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent. Am J Physiol. 283:2002;G947-G956.
401. Westwick J.K., Bielawska A.E., Dbaibo G., Hannun Y.A., Brenner D.A. Ceramide activates the stress-activated protein kinase. J Biol Chem. 270:1995;22689-22692.
402. Whetstone H., Lingwood C. 3′sulfogalactolipid binding specifically inhibits Hsp70 ATPase activity in vitro. Biochemistry. 42:2003;1611-1617.
403. Whitesell L., Mimnaugh E.G., de Costa B., Myers C.E., Neckers L.M. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA. 91:1994;8324-8328.
404. Wick G., Grubeck-Loebenstein B. Immunity and aging. Dev Comp Immunol. 21:1997;455-460.
405. Wong H.R., Menendez I.Y., Ryan M.A., Denenberg A.G., Wispe J.R. Increased expression of heat shock protein-70 protects A549 cells against hyperoxia. Am J Physiol. 275:1998;L836-L841.
406. Workman P. Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics. Mol Cancer Ther. 2:2003;131-138.
407. Xanthoudakis S., Roy S., Rasper D., Hennessey T., Aubin Y., Cassady R., Tawa P., Ruel R., Rosen A., Nicholson D.W. Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis. EMBO J. 18:1999;2049-2056.
408. Xie Q., Khaoustov V.I., Chung C.C., Sohn J., Krishnan B., Lewis D.E., Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 36:2002;592-601.
409. Yamagami K., Yamamoto Y., Toyokuni S., Hata K., Yamaoka Y. Heat shock preconditioning reduces the formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal modified proteins in ischemia-reperfused liver of rats. Free Radic Res. 36:2002;169-176.
410. Yamagishi N., Saito Y., Ishihara K., Hatayama T. Enhancement of oxidative stress-induced apoptosis by Hsp105alpha in mouse embryonal F9 cells. Eur J Biochem. 269:2002;4143-4151.
411. Yamamoto T., Manome Y., Nakamura M., Tanigawa N. Down-regulation of survivin expression by induction of the effector cell protease receptor-1 reduces tumor growth potential and results in an increased sensitivity to anticancer agents in human colon cancer. Eur J Cancer. 38:2002;2316-2324.
412. Yamauchi H., Adachi M., Sakata K., Hareyama M., Satoh M., Himi T., Takayama S., Reed J.C., Imai K. Nuclear BAG-1 localization and the risk of recurrence after radiation therapy in laryngeal carcinomas. Cancer Lett. 165:2001;103-110.
413. Yenari M.A., Fink S.L., Sun G.H., Chang L.K., Patel M.K., Kunis D.M., Onley D., Ho D.Y., Sapolsky R.M., Steinberg G.K. Gene therapy with Hsp72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol. 44:1998;584-591.
414. Yuan L.J., Christians E.S., Liu L., Xiao X., Sohal R.S., Benjamin I.J. Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J. 16:2002;5164-5172.
415. Yuan X.M., Li W., Dalen H., Lotem J., Kama R., Sachs L., Brunk U.T. Lysosomal destabilization in p53-induced apoptosis. Proc Natl Acad Sci USA. 99:2002;6286-6291.
416. Zamzami N., Marchetti P., Castedo M., Decaudin D., Macho A., Hirsch T., Susin S.A., Petit P.X., Mignotte B., Kroemer G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med. 182:1995;367-377.
417. Zanata S.M., Lopes M.H., Mercadante A.F., Hajj G.N., Chiarini L.B., Nomizo R., Freitas A.R., Cabral A.L., Lee K.S., Juliano M.A., de Oliveira E., Jachieri S.G., Burlingame A., Huang L., Linden R., Brentani R.R., Martins V.R. Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. EMBO J. 21:2002;3307-3316.
418. Zhang M., Blake M.J., Gout P.W., Buckley D.J., Buckley A.R. Proteolysis of heat shock transcription factor is associated with apoptosis in rat Nb2 lymphoma cells. Cell Growth Differ. 10:1999;759-767.
419. Zhang J.L., Patel J.M., Block E.R. Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells. Mech Ageing Dev. 123:2002;613-625.
420. Zhou P., Fernandes N., Dodge I.L., Reddi A.L., Rao N., Safran H., DiPetrillo T.A., Wazer D.E., Band V., Band H. ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem. 278:2003;13829-13837.
421. Zong W.-X., Li C., Hatzivassiliou G., Lindsten T., Yu Q.-C., Yuan J., Thompson C.B. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol. 162:2003;59-69.
422. Zou J., Guo Y., Guettouche T., Smith D.F., Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell. 94:1998;471-480.
423. Zylicz M., King F.W., Wawrzynow A. Hsp70 interactions with the p53 tumour suppressor protein. EMBO J. 20:2001;4634-4638.