The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering

Cell Death and Differentiation

Volumn 5, Issue 5, 1998, Pages 381-389

  Alesse, Edoardo ^a,b   Zazzeroni, Franceses ^a   Angelucci, Adriano ^a   Giannini, Giuseppe ^a   Di Marcotullio, Lucia ^a   Gulino, Alberto ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b Department of Experimental Medicine ^*  (Italy)

Author keywords

c myc; Ceramides; Growth arrest; P21(WAF1 CIP1 Sdi1)

Indexed keywords

CERAMIDE; CYCLIN DEPENDENT KINASE; PROTEIN P21; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; BINDING SITE; CELL GROWTH; CONTROLLED STUDY; DEPHOSPHORYLATION; DIPLOIDY; DOSE RESPONSE; ENZYME ACTIVITY; EXPRESSION VECTOR; FIBROBLAST CULTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSCRIPTION REGULATION;

PAPILLOMAVIRUS;

EID: 0031823036     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400358     Document Type: Article

References (60)

1. Arroyo M and Raychaudhuri P (1992) Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein. Nucleic Acids Res. 20: 5947-5954
2. Ballou LR (1992a) Sphingolipids and cell function, Immunol. Today 13: 339-341
3. 2 production and sphingomyalin metabolism Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J. Biol. Chem. 267:20044-20050
4. Blake M and Azizkhan JC (1989) Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol. 9: 4994-5002
5. Buttke TM, McCubrey JA and Owen TC (1993) Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines J. Immunol. Methods 157: 233
6. Chellappan SP (1994) The E2F transcription factor. role in cell cycle regulation and differentiation Mol. Cell. Differentiation 2. 201-220
7. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM and Nevins JR (1991) The E2F transcription factor is a cellular target for Rb protein Cell 65: 1053-1061
8. Dalton S (1992) Cell cycle regulation of the human cdc2 gene. EMBO J. 11: 1797-1804
9. Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM and Hannun YA (1995) Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Nalt. Acad. Sci. USA. 92 1347-1351
10. DeCaprio JA, Ludlow JW, Lynch D, Furukama Y, Griffin J, Piwnica-Worms H, Huang CM and Livingston DM (1989) The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58: 1085-1095
11. Dobrowsky RT and Hannun YA (1992) Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem 267: 5048-5051
12. Dobrowsky RT, Kamibayashi C, Mumby MC and Hannun YA (1993) Ceramide activates heterotrimeric protein phosphatase 2A. J. Biol. Chem. 268: 15523-15530
13. Dobrowsky RT, Werner MK, Castellino AM, Moses VC and Hannun YA (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265. 1596-1599
14. Dressler KA, Mathias S and Kolesnick RN (1992) Tumor necrosis factor-α activates the sphingomyelin signal transduction pathway in a cell-free system Science 255: 1715-1718
15. Duke RC and Cohen JJ (1992) Morphological and biochemical assay of apoptosis. In Current Protocols in Immunology, JE Coligan and AM Kruisbeak, eds. (New York. John Wiley & Sons) pp. 3.17.1-3.17.16
16. Dynlacht BD, Flores O, Lees JA and Harlow E (1994) Differential regulation of E2F trans-activation by cyclin/cdk2 complexes. Genes Dev. 8: 1772-1786
17. El-Deiry WS, Tokino T, Velculesco VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Wogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825
18. Evan GI. Wyllie AH, Gilbert CS, Littelewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock D (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128
19. Fung Y-KT, Tang A, Murphree L, Zhang F-H, Qui W-R, Wang S-W, Shi S-H, Lee L, Driscoll B and Wu K-J (1993) The Rb gene suppresses the growth of normal cells. Oncogene 8: 2659-2672
20. Goldkorn T, Dressler KA, Muindi J, Radin NS, Mendelsohn J, Menaldino D, Liotta D and Kolesnick RN (1991) Ceramide stimulates epidermal growth factor receptor phosphorylationin AG31 human epidermoid carcinoma cells. J Biol. Chem 266 16092-16097
21. Good L, Dimri GP, Campisi J and Chen KY (1996) Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J. Cell Phys 168: 580-588
22. German CM, Moffat LF and Howard BH (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells Mol. Cell. Biol. 2. 1044-1051
23. Gu W, Bhatia K, Magrath IT, Dang CV and Dalla-Favera R (1994) Binding and suppression of the Myctranscriptional activational domain by p107. Science 264: 251-254
24. Hannun YA (1994) The sphingomyelin cycle and the second messenger function of ceramide. J. Biol Chem. 269: 3125-3128
25. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ (1993) The p21 cdk-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816
26. Helin K and Harlow E (1993) The retinoblastoma protein as a transcriptional repressor. Trend Cell Biol. 3: 43-46
27. Hiebert S (1993) Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol. Cell. Biol. 13: 3384-3391
28. Hunter T and Pines J (1991) Cyclins and cancer. Cell 66: 1071-1074
29. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MY, Obeid LM and Hannun YA (1995) Role for ceramide in cell cycle arrest. J. Biol. Chem. 270: 2047-2052
30. Kim M, Linardic C, Obeid L and Hannun YA (1991) Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. J. Biol. Chem. 266: 484-489
31. Kolesnick R and Golde DW (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling Cell 77: 325-328
32. La Thangue NB (1994) DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19 108-114
33. Lees E, Faha B, Dulic V, Reed SI and Harlow E (1992) Cyclin E/cdk2 and cyclin A/ cdk2 kinases associate with p107 and E2F in temporally distinct manner. Genes Dev. 6. 1874-1885
34. Lukas J, Muller H, Bartkova J, Spitkovsky D, Kjierulff AA, Jansen-Durr P, Strauss M and Bartek J (1994) DNA tumor virus oncoptroteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J. Cell Biol. 125 625-638
35. Lukas P, Bartkova J and Bartek J (1996) Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclindependent kinase-pRb-controlled G1 checkpoint. Mol. Cell. Biology 16. 6917-6925
36. Marcu KB, Bossone SA and Patel AJ (1992) myc function and regulation. Annu. Rev. Biochem. 61: 809-860
37. Mathias S, Dressler KA and Kolesnick RN (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor α. Proc. Natl Acad. Sci. USA 88: 10009-10013
38. Mathias S, Younes A, Kan C, Orlow I, Joseph C and Kolesnick RN (1993) Activation of the sphingomyelin signaling pathway in intact EL4-cells and in a cell-free system by IL-1β. Science 259: 519-522
39. Moran E (1993) DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Dev. 3. 63-70
40. Mudryj M, Devoto SH, Hiebert SW, Hunter T, Pines J and Nevins JR (1991) Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65. 1243-1253
41. Mudryi M, Hiebert SW and Nevins JR (1990) A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 9. 2179-2184
42. Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258: 424-429
43. Noda A, Ning Y, Venable SF, Pereira-Smith O and Smith JR (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exper. Cell Res 211: 90-98
44. Obeid LM, Linardic CM, Karolak LA and Hannun YA (1992) Programmed cell death induced by ceramide. Science 259: 1769-1771
45. 3-induced HL-60 cell differentiation. J. Biol. Chem 265: 15823-15831
46. Packhman G and Cleveland JL (1995) c-myc and apoptosis BBA 1242: 11-28
47. Papp B, Zhang D, Groopman GE and Byrn RA (1994) Stimulation of human immunodeficiency virus type I expression by ceramide AIDS Res. Hum. Retr. 7: 775-780
48. Pearson BE, Nasheuer HP and Wang TSF (1991) Human DNA polymerase α gene: sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol 11 2081-2095
49. Qin XQ, Chittenden T, Livingston D and Kaelm WG (1992) Identification of growth suppression domain within the retinoblastoma gene product. Genes Dev. 6: 953-964
50. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A and Weinberg R (1995) E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad Sci. USA. 92: 2403-2407
51. 1 phase integrators of the mitogenic response. In Cold Spring Harbor Symposia on Quantitative Biology, (Cold Spring Harbor Laboratory Press) pp 11-19
52. Shiyanov P, Bagchi S, Adami G, Kokontis J, Hay N, Arroyo M, Morozov A and Raychaudhuri P (1996) p21 Disrupt the interaction between cdk2 and the E2F-p 130 complex. Mol. Cell. Biol 16: 737-744
53. Thalmeier K, Synovzik H, Mertz R, Winnacker EL and Lipp M (1989) Nuclear factor E2F mediates basic transcription and trans-activation by E1A of human MYC promoter Genes Dev. 3: 527-536
54. Vairo G, Livingston DM and Ginsberg D (1995) Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma family members. Genes Dev. 9. 869-881
55. Venable ME, Lee JY, Smyth MJ. Bielawska A and Obeid LM (1995) Role of ceramide in cellular senescence. J. Biol Chem. 270: 30701-30708
56. Verheij M, Bose R, Li XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z and Kolesnick RN (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis Nature 380: 75-79
57. Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM and Hannun YA (1994) Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J. Biol. Chem. 269. 19605-19609
58. Xiong Y, Hannon G, Zhang H, Casso D, Kobayashi R and Beach D (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704
59. Yang Z, Costanzo M, Golde DW and Kolesnick RN (1993) Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kB translocation in intact HL-60 cells. J. Biol. Chem. 268. 20520-20523
60. Yao B, Zhang Y, Delikat S, Mathias S, Basu S and Kolesnick RN (1995) Phosphorylation of Raf by ceramide-activated protein kinase. Nature 378. 307-310