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Volumn 83, Issue 2, 2002, Pages 452-462

Stress-mediated signaling in PC12 cells - The role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal

Author keywords

Heat stress; Immunoblotting; Immunocytochemistry; Neural protection; PC12 cells; Signal transduction

Indexed keywords

HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN KINASE B;

EID: 0036798777     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01151.x     Document Type: Article
Times cited : (79)

References (47)
  • 1
    • 0035975622 scopus 로고    scopus 로고
    • Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration
    • Akbar M. T., Wells D. J., Latchman D. S. and de Belleroche J. (2001) Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration. Mol. Brain Res. 93, 148-163.
    • (2001) Mol. Brain Res. , vol.93 , pp. 148-163
    • Akbar, M.T.1    Wells, D.J.2    Latchman, D.S.3    De Belleroche, J.4
  • 2
    • 0029962777 scopus 로고    scopus 로고
    • Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies
    • Amin V., Cumming D. V. and Latchman D. S. (1996) Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies. Neurosci. Lett. 206, 45-48.
    • (1996) Neurosci. Lett. , vol.206 , pp. 45-48
    • Amin, V.1    Cumming, D.V.2    Latchman, D.S.3
  • 3
    • 0023697402 scopus 로고
    • Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein
    • Arrigo A.-P., Suhan J. P. and Welch W. J. (1988) Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein. Mol. Cell Biol. 8, 5059-5071.
    • (1988) Mol. Cell Biol. , vol.8 , pp. 5059-5071
    • Arrigo, A.-P.1    Suhan, J.P.2    Welch, W.J.3
  • 4
    • 0033982222 scopus 로고    scopus 로고
    • Heat shock proteins Hsp27 and Hsp32 localize to synaptic sites in the rat cerebellum following hyperthermia
    • Bechtold D. A. and Brown I. R. (2000) Heat shock proteins Hsp27 and Hsp32 localize to synaptic sites in the rat cerebellum following hyperthermia. Mol. Brain Res. 75, 309-320.
    • (2000) Mol. Brain Res. , vol.75 , pp. 309-320
    • Bechtold, D.A.1    Brown, I.R.2
  • 5
    • 0033773645 scopus 로고    scopus 로고
    • Opposing actions of phosphatyidylinositol 3-kinase and glycogen synthase kinase-3-beta in the regulation of HSF-1 activity
    • Bijur G. N. and Jope R. S. (2000) Opposing actions of phosphatyidylinositol 3-kinase and glycogen synthase kinase-3-beta in the regulation of HSF-1 activity. J. Neurochem. 75, 2401-2408.
    • (2000) J. Neurochem. , vol.75 , pp. 2401-2408
    • Bijur, G.N.1    Jope, R.S.2
  • 6
    • 0033796051 scopus 로고    scopus 로고
    • Inhibition of Daxx-mediated apoptosis by heat shock protein 27
    • Charette S. J., Lavoie J. N., Lambert H. and Landry J. (2000) Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell Biol. 20, 7602-7612.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 7602-7612
    • Charette, S.J.1    Lavoie, J.N.2    Lambert, H.3    Landry, J.4
  • 7
    • 0034963578 scopus 로고    scopus 로고
    • Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c
    • Concannon C. G., Orrenius S. and Samali A. (2001) Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. Gene Expr. 9, 195-201.
    • (2001) Gene Expr. , vol.9 , pp. 195-201
    • Concannon, C.G.1    Orrenius, S.2    Samali, A.3
  • 9
    • 0034724792 scopus 로고    scopus 로고
    • Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27
    • Currie R. W., Ellison J. A., White R. F., Fauerstein G. J., Wang X. and Barone F. C. (2000) Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27. Brain Res. 863, 169-181.
    • (2000) Brain Res. , vol.863 , pp. 169-181
    • Currie, R.W.1    Ellison, J.A.2    White, R.F.3    Fauerstein, G.J.4    Wang, X.5    Barone, F.C.6
  • 10
    • 0029977479 scopus 로고    scopus 로고
    • Neuronal differentiation in PC12 cells is accompanied by diminished inducibility of Hsp70 and Hsp60 in response to heat and ethanol
    • Dwyer D. S., Liu Y., Miao S. and Bradley R. J. (1996) Neuronal differentiation in PC12 cells is accompanied by diminished inducibility of Hsp70 and Hsp60 in response to heat and ethanol. Neurochem. Res. 21, 659-666.
    • (1996) Neurochem. Res. , vol.21 , pp. 659-666
    • Dwyer, D.S.1    Liu, Y.2    Miao, S.3    Bradley, R.J.4
  • 13
    • 0037205441 scopus 로고    scopus 로고
    • Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells
    • Geum D., Son G. H. and Kim K. (2002) Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells. J. Biol. Chem. 277, 19913-19921.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19913-19921
    • Geum, D.1    Son, G.H.2    Kim, K.3
  • 14
    • 0031056783 scopus 로고    scopus 로고
    • Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
    • Guay H., Lambert H., Gingras-Breton G., Lavoie J. N., Huot J. and Landry J. (1997) Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J. Cell Sci. 110, 357-368.
    • (1997) J. Cell Sci. , vol.110 , pp. 357-368
    • Guay, H.1    Lambert, H.2    Gingras-Breton, G.3    Lavoie, J.N.4    Huot, J.5    Landry, J.6
  • 15
    • 0035895994 scopus 로고    scopus 로고
    • Inhibition of JNK by overexpression of the JNK binding domain of JIP-1 prevents apoptosis in sympathetic neurons
    • Harding T. C., Luzheng X., Bienemann A., Haywood D., Dickens M., Tolkovsky A. M. and Uney J. B. (2001) Inhibition of JNK by overexpression of the JNK binding domain of JIP-1 prevents apoptosis in sympathetic neurons. J. Biol. Chem. 276, 4531-4534.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4531-4534
    • Harding, T.C.1    Luzheng, X.2    Bienemann, A.3    Haywood, D.4    Dickens, M.5    Tolkovsky, A.M.6    Uney, J.B.7
  • 16
    • 0030728118 scopus 로고    scopus 로고
    • Reduced induction of Hsp70 in PC12 cells during neuronal differentiation
    • Hatayama T., Takahashi H. and Yamagishi N. (1997) Reduced induction of Hsp70 in PC12 cells during neuronal differentiation. J. Biochem. (Tokyo) 122, 904-910.
    • (1997) J. Biochem. (Tokyo) , vol.122 , pp. 904-910
    • Hatayama, T.1    Takahashi, H.2    Yamagishi, N.3
  • 17
    • 0025777354 scopus 로고
    • Heat shock proteins, chaperones and proteotoxicity
    • Hightower L. (1991) Heat shock proteins, chaperones and proteotoxicity. Cell 66, 191-197.
    • (1991) Cell , vol.66 , pp. 191-197
    • Hightower, L.1
  • 18
    • 0032192097 scopus 로고    scopus 로고
    • Induction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury
    • Hopkins D. A., Plumier J. C. and Currie R. W. (1998) Induction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury. Exp. Neurol. 153, 173-183.
    • (1998) Exp. Neurol. , vol.153 , pp. 173-183
    • Hopkins, D.A.1    Plumier, J.C.2    Currie, R.W.3
  • 19
    • 0028832107 scopus 로고
    • Characterization of 45kDA/54kDA HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27kDA heat shock protein HSP27
    • Huot J., Lambert H., Lavoie J. N., Guimond A., Houle F. and Landry J. (1995) Characterization of 45kDA/54kDA HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27kDA heat shock protein HSP27. Eur. J. Biochem. 277, 416-427.
    • (1995) Eur. J. Biochem. , vol.277 , pp. 416-427
    • Huot, J.1    Lambert, H.2    Lavoie, J.N.3    Guimond, A.4    Houle, F.5    Landry, J.6
  • 20
    • 0030069517 scopus 로고    scopus 로고
    • HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress
    • Huot J., Houle F., Spitz R. and Landry J. (1996) HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res. 56, 273-279.
    • (1996) Cancer Res. , vol.56 , pp. 273-279
    • Huot, J.1    Houle, F.2    Spitz, R.3    Landry, J.4
  • 21
    • 0034605446 scopus 로고    scopus 로고
    • Role of the heat shock response and molecular chaperones in oncogenesis and cell death
    • Jolly C. and Morimoto R. I. (2000) Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J. Natl. Cancer Inst. 92, 1564-1572.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1564-1572
    • Jolly, C.1    Morimoto, R.I.2
  • 22
    • 0032837149 scopus 로고    scopus 로고
    • Selective stimulation of Hsp27 and alphaB-crystallin but not Hsp70 expression by p38 MAP kinase activation
    • Kato K., Ito H., Kamei K. and Iwamoto I. (1999) Selective stimulation of Hsp27 and alphaB-crystallin but not Hsp70 expression by p38 MAP kinase activation. Cell Stress Chaperones 4, 94-101.
    • (1999) Cell Stress Chaperones , vol.4 , pp. 94-101
    • Kato, K.1    Ito, H.2    Kamei, K.3    Iwamoto, I.4
  • 23
    • 0035869733 scopus 로고    scopus 로고
    • Neurite growth by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: Role of phosphoinositide 3-kinase and mitogen activated protein kinase
    • Kimpinksi K. and Mearow K. M. (2001) Neurite growth by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase. J. Neurosci. Res. 63, 486-499.
    • (2001) J. Neurosci. Res. , vol.63 , pp. 486-499
    • Kimpinksi, K.1    Mearow, K.M.2
  • 24
    • 0030785701 scopus 로고    scopus 로고
    • Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27
    • Konishi H., Matsuzaki H., Tanaka M., Takemura Y., Kuroda S., Ono Y. and Kikkawa U. (1997) Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett. 410, 493-498.
    • (1997) FEBS Lett. , vol.410 , pp. 493-498
    • Konishi, H.1    Matsuzaki, H.2    Tanaka, M.3    Takemura, Y.4    Kuroda, S.5    Ono, Y.6    Kikkawa, U.7
  • 25
    • 0011013727 scopus 로고    scopus 로고
    • Hyperthermic induction of the 27 kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system
    • Krueger-Naug A. M., Hopkins D. A., Armstrong J. N., Plumier J. C. and Currie R. W. (2000) Hyperthermic induction of the 27 kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system. J. Comp Neurol. 75, 2401-2408.
    • (2000) J. Comp Neurol. , vol.75 , pp. 2401-2408
    • Krueger-Naug, A.M.1    Hopkins, D.A.2    Armstrong, J.N.3    Plumier, J.C.4    Currie, R.W.5
  • 26
    • 0024345716 scopus 로고
    • Heat shock resistance conferred by the expression of the human HSP27 gene in rodent cells
    • Landry J., Chretien P., Lambert H., Hickey E. and Weber L. A. (1989) Heat shock resistance conferred by the expression of the human HSP27 gene in rodent cells. J. Cell Biol. 109, 7-15.
    • (1989) J. Cell Biol. , vol.109 , pp. 7-15
    • Landry, J.1    Chretien, P.2    Lambert, H.3    Hickey, E.4    Weber, L.A.5
  • 27
    • 0025727532 scopus 로고
    • Phosphorylation of HSP27 during development and decay of thermotolerance in Chinese hamster cells
    • Landry J., Chretien P., Laszlo A. and Lambert H. (1991) Phosphorylation of HSP27 during development and decay of thermotolerance in Chinese hamster cells. J. Cell. Physiol. 147, 93-101.
    • (1991) J. Cell. Physiol. , vol.147 , pp. 93-101
    • Landry, J.1    Chretien, P.2    Laszlo, A.3    Lambert, H.4
  • 28
    • 0025374119 scopus 로고
    • Sequence of the Chinese hamster small heat shock protein HSP27
    • Lavoie J., Chretien P. and Landry J. (1990) Sequence of the Chinese hamster small heat shock protein HSP27. Nucleic Acids Res. 18, 1637.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 1637
    • Lavoie, J.1    Chretien, P.2    Landry, J.3
  • 29
    • 0028924759 scopus 로고
    • Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
    • Lavoie J. N., Lambert H., Hickey E., Weber L. A. and Landry J. (1995) Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol. Cell Biol. 15, 505-516.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 505-516
    • Lavoie, J.N.1    Lambert, H.2    Hickey, E.3    Weber, L.A.4    Landry, J.5
  • 31
    • 0034954215 scopus 로고    scopus 로고
    • Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions
    • Lee J. E., Yenari M. A., Sun G. H., Xu L., Emond M. R., Cheng D., Steinberg G. K. and Giffard R. G. (2001b) Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions. Exp. Neurol. 170, 129-139.
    • (2001) Exp. Neurol. , vol.170 , pp. 129-139
    • Lee, J.E.1    Yenari, M.A.2    Sun, G.H.3    Xu, L.4    Emond, M.R.5    Cheng, D.6    Steinberg, G.K.7    Giffard, R.G.8
  • 33
    • 0027973005 scopus 로고
    • Heat shock proteins Hsp90 and Hsp70 protect neuronal cells from thermal stress but not from programmed cell death
    • Mailhos C., Howard M. K. and Latchman D. S. (1994) Heat shock proteins Hsp90 and Hsp70 protect neuronal cells from thermal stress but not from programmed cell death. J. Neurochem. 63, 1787-1795.
    • (1994) J. Neurochem. , vol.63 , pp. 1787-1795
    • Mailhos, C.1    Howard, M.K.2    Latchman, D.S.3
  • 34
    • 0033970158 scopus 로고    scopus 로고
    • JNK and p38 stress kinases - Degenerative effectors of signal-transduction-cascades in the nervous system
    • Mielke K. and Herdegen T. (2000) JNK and p38 stress kinases - degenerative effectors of signal-transduction-cascades in the nervous system. Prog. Neurobiol. 61, 45-60.
    • (2000) Prog. Neurobiol. , vol.61 , pp. 45-60
    • Mielke, K.1    Herdegen, T.2
  • 36
    • 0032501426 scopus 로고    scopus 로고
    • Acute infection of sindbis virus induces phosphorylation and intracellular translocation of small heat shock protein hsp27 and activation of p38 MAP kinase signaling pathway
    • Nakatsue T., Katoh I., Nakamura S., Takahashi Y., Ikawa Y. and Yoshinaka Y. (1998) Acute infection of sindbis virus induces phosphorylation and intracellular translocation of small heat shock protein hsp27 and activation of p38 MAP kinase signaling pathway. Biochem. Biophys. Res. Commun. 253, 59-64.
    • (1998) Biochem. Biophys. Res. Commun. , vol.253 , pp. 59-64
    • Nakatsue, T.1    Katoh, I.2    Nakamura, S.3    Takahashi, Y.4    Ikawa, Y.5    Yoshinaka, Y.6
  • 37
    • 0034665175 scopus 로고    scopus 로고
    • Roles of molecular chaperones in the nervous system
    • Ohtsuka K. and Suzuki T. (2000) Roles of molecular chaperones in the nervous system. Brain Res. Bull. 53, 141-146.
    • (2000) Brain Res. Bull. , vol.53 , pp. 141-146
    • Ohtsuka, K.1    Suzuki, T.2
  • 40
    • 0039171658 scopus 로고    scopus 로고
    • Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα and hydrogen peroxide-induced cell death
    • Preville X., Schults H., Knauf U., Gaestel M. and Arrigo A.-P. (1998) Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα and hydrogen peroxide-induced cell death. J. Cell. Biochem. 69, 436-452.
    • (1998) J. Cell. Biochem. , vol.69 , pp. 436-452
    • Preville, X.1    Schults, H.2    Knauf, U.3    Gaestel, M.4    Arrigo, A.-P.5
  • 42
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAP-KAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T. and Nebreda A. R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAP-KAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 43
    • 0034718540 scopus 로고    scopus 로고
    • Modulation of Akt kinase activity by binding to Hsp90
    • Sato S., Fujita N. and Tsurou T. (2000) Modulation of Akt kinase activity by binding to Hsp90. Proc. Natl Acad. Sci. USA 97, 10832-10837.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10832-10837
    • Sato, S.1    Fujita, N.2    Tsurou, T.3
  • 44
    • 0032533546 scopus 로고    scopus 로고
    • 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
    • 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J. 336, 241-246.
    • (1998) Biochem. J. , vol.336 , pp. 241-246
    • Shaw, M.1    Cohen, P.2    Alessi, D.R.3
  • 45
    • 0026457201 scopus 로고
    • Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
    • Stokoe D., Emgel K., Campbell D. G., Cohen P. and Gaestel M. (1992) Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 313, 307-313.
    • (1992) FEBS Lett. , vol.313 , pp. 307-313
    • Stokoe, D.1    Emgel, K.2    Campbell, D.G.3    Cohen, P.4    Gaestel, M.5
  • 47
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R. J. and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5


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