Autophagic cell death and its execution by lysosomal cathepsins

Archives of Histology and Cytology

Volumn 64, Issue 3, 2001, Pages 233-246

  Uchiyama, Y ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CATHEPSIN; CATHEPSIN B; CATHEPSIN D; CYTOCHROME C; SOMATOMEDIN B RECEPTOR;

AUTOPHAGY; CELL DEATH; ENZYME ACTIVITY; GERBIL; GOLGI COMPLEX; HUMAN; INTRACELLULAR TRANSPORT; LYSOSOME; MITOCHONDRION; NONHUMAN; PHAGOSOME; PHEOCHROMOCYTOMA CELL; PROTEIN TRANSPORT; PYRAMIDAL NERVE CELL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034849783     PISSN: 09149465     EISSN: None     Source Type: Journal    
DOI: 10.1679/aohc.64.233     Document Type: Review

References (60)

1. Cathepsin D and other carboxyl proteinases
2. Cathepsin B, cathepsin H, cathepsin L
3. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity
4. Internucleosomal DNA cleavage and neuronal cell survival/death
5. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
6. Active cell death induced by the anti-estrogens tamoxifen and ICI164384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
7. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
8. Developmental cell death: Morphological diversity and multiple mechanisms
9. Insulin-like growth factor II/cation-independent mannose 6-phosphate receptor and lysosomal enzyme recognition
10. Cathepsin D protease mediates programmed cell death induced by interferon-g, Fas/APO-1 and TNF-a
11. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
12. Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
13. Studies on the mechanisms of autophagy: Maturation of the autophagic vacuole
14. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
15. Lysosomal enzymes and their receptors
16. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
17. Mechanisms of intralysosomal degradation with special reference to autophagocytosis and heterophagocytosis of cell organelles
18. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promotig mitochondrial release of cytochrome c
19. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
20. A ubiquitin-like system mediates protein lipidation
21. Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
22. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after procesing
23. The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress
24. Overexpression of cation-dependent mannose 6-phosphate receptor prevents cell death induced by serum deprivation in PC12 cells
25. Apoptosis: A basic biological phenomenon with wide ranging implication in tissue kinetics
26. Vacuolar import of proteins and organelles from the cytoplasm
27. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons
28. Distribution of cathepsins B and H in rat tissues and peripheral blood cells
29. The biogenesis of lysosomes
30. Activation of caspase-2 in apoptosis
31. Induction of autophagy and inhibition of tumorigenesis by beclin 1
32. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
33. DFF, a heterodimaric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
34. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
35. Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization
36. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts
37. A protein conjugation system essential for autophagy
38. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
39. Re-expression of the mannose 6-phosphate receptors in receptor-deficient fibroblasts. Complementary function of the two mannose 6-phosphate receptors in lysosomal enzyme targeting
40. Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport
41. Caspases: Killer proteases
42. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
43. Lysosomal cysteine and aspartic proteinases, acid phosphatase, and an endogenous cyteine proteinase inhibitor, cystatin b in rat osteoclasts
44. The two mannose 6-phosphate receptors transport distinct complements of lysosomal proteins
45. Immunolocalization of cathepsin D in normal and neoplastic human tissues
46. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
47. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
48. Caspase activation: The induced-proximity model
49. Neuronal differentiation of PC12 cells as a result of prevention of cell death by bcl-2
50. Cloning and expression of the cDNA encoding rat caspase-2
51. The fate of effete epithelial cells at the villus tip of human small intestine
52. Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation
53. Apoptosis: The history and trends of its studies
54. Cell and tissue distribution of lysosomal cysteine proteinases, cathepsins B, H, and L, and their biological roles
55. Different distribution patterns of the two mannose 6-phosphate receptors in rat liver
56. Immunocytochemical localization of cathepsin D in rat neural tissue
57. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
58. Characterization of new fluorogenic substrates for the rapid and sensitive assayof cathepsin E and cathepsin D
59. Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes
60. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3