Initiation of apoptosis by granzyme B requires direct cleavage of Bid, but not direct granzyme B-mediated caspase activation

Journal of Experimental Medicine

Volumn 192, Issue 10, 2000, Pages 1403-1413

  Sutton, Vivien R ^a   Davis, Joanne E ^a   Cancilla, Michael ^b   Johnstone, Ricky W ^a   Ruefli, Astrid A ^a   Sedelies, Karin ^a   Browne, Kylie A ^a   Trapani, Joseph A ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Apoptosis; Bcl 2; Bid; Granzyme B; Perforin

Indexed keywords

CASPASE; GRANZYME B; KETONE DERIVATIVE; PROTEIN; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; MEMBRANE DEPOLARIZATION; MITOCHONDRION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BONE MARROW CELLS; CARRIER PROTEINS; CASPASES; CELLS, CULTURED; ENZYME ACTIVATION; GRANZYMES; HUMANS; JURKAT CELLS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-BCL-2; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 0034694091     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.10.1403     Document Type: Article

References (45)

1. 2+-independent T cell-mediated cytotoxicity
2. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
3. Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
4. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
5. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
6. A natural killer cell granule protein that induces DNA fragmentation and apoptosis
7. Localization of granzyme B in the nucleus: A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis
8. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
9. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
10. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
11. Processing of the Nedd2 precursor by ICE-like proteases and granzyme B
12. Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis
13. Reconstitution of nuclear and nucleolar transport of the natural killer cell serine protease granzyme B-dependence on perforin in vivo and cytosolic factors in vitro
14. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7
15. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
16. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
17. Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases
18. Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
19. Granzyme B-induced loss of mitochondrial inner membrane potential and cytochrome c release are caspase independent
20. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
21. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
22. Prevention of apoptosis by a baculovirus gene during infection of insect cells
23. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
24. Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1
25. Bcl-2 prevents death of factor deprived cells but fails to prevent apoptosis in targets of cell mediated killing
26. An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1
27. BCL-2 blocks perforin-induced nuclear translocation of granzymes, concomitant with protection against the nuclear events of apoptosis
28. Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis
29. Bcl-2 prevents the release from mitochondria of an apoptotogenic protease
30. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid
31. Differences between CD95 type I and II cells detected with the CD95 ligand
32. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry
33. Selective regulation of apoptosis: The cellular serpin proteinase inhibitor-9 prevents granzyme B-mediated but not Fas-mediated cell death
34. Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody
35. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
36. An evolutionary perspective on apoptosis
37. Cleavage of BID during cytotoxic drug and UV radiation induced apoptosis occurs downstream of Bcl-2 and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated cytochrome c release
38. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
39. BID: A novel BH3 domain only death agonist
40. Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction
41. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
42. Hsp27 negatively regulates cell death by interacting with cytochrome c
43. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
44. Smac, a mitochondrial protein that promotes cytochrome-c-dependent caspase activation by eliminating IAP function
45. Apoptotic pathways: Paper wraps stone blunts scissors