The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

EMBO Journal

Volumn 20, Issue 14, 2001, Pages 3771-3780

  Donze O ^a   Abbas Terki, T ^a   Picard, D ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Geldanamycin; Hsp90; MAPK; Phosphorylation; PKR

Indexed keywords

CHAPERONE; DOUBLE STRANDED RNA; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN P23; RADICICOL; RAF PROTEIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MAMMAL CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; YEAST;

DIMERIZATION; EIF-2 KINASE; ENZYME ACTIVATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0035898534     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.14.3771     Document Type: Article

References (60)

1. The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest
2. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling
3. Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins
4. Hsp90 & Co. - A holding for folding
5. Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA
6. Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2
7. Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo
8. The eIF-2α kinases and the control of protein synthesis
9. Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
10. Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the α-subunit of eukaryotic translation initiation factor 2
11. Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells
12. Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression
13. SBA1 encodes a yeast hsp90 co-chaperone that is homologous to vertebrate p23 proteins
14. Differential in vivo regulation of steroid hormone receptor activation by Cdc37p
15. Molecular chaperone machines: Chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23
16. Autophosphorylation of the protein kinase dependent on double-stranded RNA
17. Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft tumor histocultures
18. p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function
19. RNA binding and modulation of PKR activity
20. Multiple signaling cascades are differentially involved in gene induction by double stranded RNA in interferon-α-primed cells
21. Overview: Phosphorylation and translation control
22. Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections
23. In vitro reconstitution of a functional duck hepatitis B virus reverse transcriptase: Posttranslational activation by hsp90
24. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids
25. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling
26. Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo
27. Binding of p23 and hsp90 during assembly with the progesterone receptor
28. Regulation of the interferon-induced PKR: Can viruses cope?
29. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
30. Cdc37 is a molecular chaperone with specific functions in signal transduction
31. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
32. Opposite effects of the Hsp90 inhibitor geldanamycin: Induction of apoptosis in PC12 and differentiation in N2A cells
33. Hsp90 is required for pheromone signaling in yeast
34. Blockage of NF-κB signaling by selective ablation of an mRNA target by 2-5A antisense chimeras
35. Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction
36. A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR
37. Mutational analysis of Hsp90 function: Interactions with a steroid receptor and a protein kinase
38. Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells
39. The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase
40. Steroid receptor interactions with heat shock protein and immunophilin chaperones
41. The regulation of the protein kinase PKR by RNA
42. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
43. Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2α kinases PKR and GCN2
44. Functional characterization of the RNA binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR)
45. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association
46. Geldanamycin-induced destabilization of Raf-1 involves the proteasome
47. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
48. Understanding Ras: 'It ain't over 'til it's over'
49. Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent
50. Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway
51. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
52. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
53. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
54. Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor
55. Mechanism of interferon action: Autoregulation of RNA-dependent P1/eIF-2α protein kinase (PKR) expression in transfected mammalian cells
56. Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2α (eIF2α)
57. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
58. PKR; a sentinel kinase for cellular stress
59. A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR
60. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1