Apoptosis-inducing factor (AIF): A novel caspase-independent death effector released from mitochondria

Biochimie

Volumn 84, Issue 2-3, 2002, Pages 215-222

  Candé, Céline ^a   Cohen, Isabelle ^a   Daugas, Eric ^a   Ravagnan, Luigi ^a   Larochette, Nathanael ^a   Zamzami, Naoufal ^a   Kroemer, Guido ^a  

^a CNRS   (France)

Author keywords

Bcl 2; Cytochrome c; Heat shock protein; Programmed cell death

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANISOMYCIN; APOPTOSIS INDUCING FACTOR; APOPTOSIS INDUCING FACTOR ANTIBODY; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; AZIDE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BETULIC ACID; CASPASE; CASPASE INHIBITOR; CERAMIDE; CHLORAMBUCIL; CISPLATIN; CYTOCHROME C; DEXAMETHASONE; DNA FRAGMENT; DOXORUBICIN; ETOPOSIDE; FLAVOPROTEIN; GANGLIOSIDE GD3; GROWTH FACTOR; HEAT SHOCK PROTEIN 70; MENADIONE; PROTEIN ANTIBODY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SORBITOL; STAUROSPORINE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

APOPTOSIS; CELL NUCLEUS; CHROMATIN CONDENSATION; CYTOSOL; EFFECTOR CELL; EMBRYONAL TISSUE; ENZYME ACTIVITY; GENE INACTIVATION; GENE TRANSLOCATION; HUMAN; INJECTION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MORPHOGENESIS; NONHUMAN; PHYLOGENY; PROTECTION; PROTEIN BINDING; PROTEIN INTERACTION; REVIEW; STEM CELL; ULTRAVIOLET RADIATION;

EID: 0036479012     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(02)01374-3     Document Type: Article

References (51)

1. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
2. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
3. Mitochondrial control of nuclear apoptosis
4. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
5. Apoptosis of cells lacking mitochondrial DNA
6. A cytofluorometric assay of nuclear apoptosis induced in a cell-free system. Application to ceramide-induced apoptosis
7. The central executioner of apoptosis. Multiple links between protease activation and mitochondria in Fas/Apo-1/CD95- and ceramide-induced apoptosis
8. Cytofluorometric quantitation of nuclear apoptosis induced in a cell free system
9. Molecular characterization of mitochondrial apoptosis-inducing factor
10. Apoptosis-inducing factor (AIF): A phylogenetically old, caspase-independent effector of cell death
11. Apoptosis inducing factor: An ubiquitous mitochondrial oxidoreductase involved in apoptosis regulation
12. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
13. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor
14. Two distinct pathways leading to nuclear apoptosis
15. NADH-oxidase activity of mitochondrial apoptosis-inducing factor (AIF)
16. Apoptosis control in syncytia induced by the HIV-1-envelope glycoprotein complex. Role of mitochondria and caspases
17. The mitochondrion in cell death control. Certainties and incognita
18. Heat shock protein 70 antagonizes apoptosis-inducing factor
19. Mitochondrio-nuclear redistribution of AIF in apoptosis and necrosis
20. A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis
21. Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo
22. HIV induced lymphocyte apoptosis by a p53-iniated, mitochondrion-mediated mechanism
23. Apoptosis of syncytia induced by HIV-1-Envelope glycoprotein complex. Influence of cell shape and size
24. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
25. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
26. The proto-oncogene Bcl-2 and its role in regulating apoptosis
27. Mitochondrial control of cell death
28. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
29. Differential requirement for caspase 9 in apoptotic pathways in vivo
30. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
31. Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo
32. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
33. Negative regulation of the Apaf-1 apoptosome by Hsp70
34. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1
35. Stress management - Heat shock protein-70 and the regulation of apoptosis
36. Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells
37. ATPase activity of the heat shock protein hsp72 is dispensable of its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis
38. Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain
39. T cell lymphoma in transgenic mice expressing the human Hsp70 gene
40. Oncogenic potential of Hsp72
41. Caspase-independent commitment to apoptosis in activated blood T lymphocytes
42. Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts
43. Molecular ordering of apoptosis induced by anti-cancer drugs in neuroblastoma cells
44. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
45. Involvement of apoptosis-inducing factor during dolichyl monophosphate-induced apoptosis in U937 cells
46. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells
47. Mitochondrial release of apoptosis-inducing factor and cytochrome c during smooth muscle cell apoptosis
48. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
49. Deoxyyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
50. The adenine nucleotide translocator: A target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
51. In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: A potential role of 4-hydroxynonenal