Granzymes: A family of lymphocyte granule serine proteases

Genome Biology

Volumn 2, Issue 12, 2001, Pages

  Trapani, Joseph A ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PROTEIN; ASPARTIC ACID; CASPASE; CHYMASE; CHYMOTRYPSIN; CYSTEINE PROTEINASE; DIPEPTIDE; ENZYME PRECURSOR; GRANZYME A; GRANZYME B; METHIONINE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SIGNAL PEPTIDE; TRYPSIN; TRYPTASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; CELL DEATH; CELL GRANULE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GENE CLUSTER; GENE LOCUS; GENETIC CODE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; REVIEW; TARGET CELL; VIRUS INFECTION;

ANIMALS; APOPTOSIS; BINDING SITES; EVOLUTION, MOLECULAR; GRANZYMES; HUMANS; KILLER CELLS, NATURAL; MICE; MODELS, MOLECULAR; RATS; SECRETORY VESICLES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERPINS; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES, CYTOTOXIC;

ANIMALIA; RODENTIA;

EID: 0035717034     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (16)

1. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation
2. The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases
3. Molecular cloning of human cathepsin G: Structural similarity to mast cell and cytotoxic T lymphocyte proteinases
4. Granzymes: A variety of serine protease specificities encoded by genetically distinct subfamilies
5. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity
6. Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I
7. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
8. Perforin and lymphocyte-mediated cytolysis
9. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
10. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
11. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
12. Initiation of apoptosis by granzyme B requires direct cleavage of Bid, but not direct granzyme B-mediated caspase activation
13. Granzymes are the essential down-stream effector molecules for the control of primary virus infections by cytolytic leukocytes
14. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity
15. CTL granules: Evolution of vesicles essential for combating virus infections
16. Selective regulation of apoptosis: The cellular serpin proteinase inhibitor-9 prevents granzyme B-mediated but not Fas-mediated cell death