Chaperones in cell cycle regulation and mitogenic signal transduction: A review

Cell Proliferation

Volumn 33, Issue 6, 2000, Pages 341-365

  Helmbrecht, K ^a   Zeise, E ^a   Rensing, L ^a  

^a UNIVERSITY OF BREMEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CYCLIN DEPENDENT KINASE 4; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; ONCOPROTEIN; PROTEIN P27; PROTEIN P53; RAF PROTEIN; RETINOBLASTOMA PROTEIN; TYROSINE KINASE RECEPTOR; VIRUS LARGE T ANTIGEN; VIRUS SMALL T ANTIGEN;

CELL CYCLE; CENTROSOME; DNA REPLICATION; GAMETOGENESIS; HUMAN; MITOGENESIS; NONHUMAN; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR CHAPERONES; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 0033724701     PISSN: 09607722     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2184.2000.00189.x     Document Type: Review

References (245)

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3. Ordered assembly of nucleoprotein structures at the bacteriophage λ replication origin during the initiation of DNA replication
4. Heat shock protein-mediated disassembly of nucleoprotein structures is required for the initiation of bacteriophage λ DNA replication
5. A role for HSP90 in cell cycle control: Wee 1 tyrosine kinase activity requires interaction with HSP90
6. HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes
7. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase
8. Heat-shock proteins as molecular chaperones
9. How chaperones fold proteins
10. Regulation of E2F. A family of transcription factors involved in proliferation control
11. Geldanamycin selectively destabilizes conformationally altered mutated p53
12. Mutant conformation of 53 translated in vitro or in vivo requires functional HSP90
13. Both viral (adenovirus E1B) and cellular (Hsp 70, p53) components interact with centrosomes
14. Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins. Analysis of the turnover and distribution of this complex
15. DnaJ/HSP 40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication
16. Transient accumulation, phosphorylation and changes in the oligomerization of HSP27 during retinoic acid-induced differentiation of HL 60 cells: Possible role in the control of cellular growth and differentiation
17. P185(cerbB2) binds to GRP94 in vivo
18. A new member of the HSP90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock
19. Hop as an adaptor in the heat shock protein 70 (HSP70) and HSP90 chaperone machinery
20. The growth transformation of human B cells involves superinduction of hsp70 and hsp90
21. Phosphorylation of HSP25 during lens cell differentiation
22. Transit of pp 60v-src to the plasma membrane
23. PD98059 prevents establishment of the spindle assembly checkpoint and inhibits the G2-M transition in meiotic but not mitotic cell cycles in Xenopus
24. Signaling and transport through the nuclear membrane
25. Mutations in hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila
26. 1
27. Physical interaction of mammalian CDC37 with CDK4
28. Geldanamycin prevents nuclear translocation of mutant p53
29. Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers
30. HSP25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes
31. MAPKs: New JNK Expands the Group
32. Identification of a protein associated with p21Ras by chemical cross linking
33. Heat shock proteins
34. CDC37 is required for p60v-src activity in yeast
35. HSP 70 expression and function during gametogenesis
36. Targeted gene disruption of HSP70-2 results in failed meiosis, germ cell apoptosis, and male infertility
37. HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes
38. Developmentally regulated expression of HSP70-2 and a HSP70-2/lacZ transgene during spermatogenesis
39. Specialized nucleoprotein structures at the origin of replication of bacteriophage λ
40. Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila
41. Role of heat shock protein HSP70-2 in spermatogenesis
42. Cyclin-dependent kinases: Inhibition and substrate recognition
43. Involvement of DnaK protein in mini-F plasmid replication: Temperature-sensitive seg mutations are located in the DnaK gene
44. The permeability of the nuclear envelope in dividing and nondividing cell cultures
45. Regulation of nuclear transport in proliferating and quiescent cells
46. Unusual expression and localization of heat-shock proteins in human tumor cells
47. Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes
48. Activating mutations for transformation by p53 produce a gene product that forms an HSC70-p53 complex with an altered halfe-life
49. TATA box dependent trans-activation of the human HSP70 promoter by Myb proteins
50. The role of the 90-kDa heat shock protein in cell cycle control and differentiation of the monoblastoid cell line U937
51. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
52. Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells
53. HSP 27 inhibits cytochrome c-dependent activation of procaspase-9
54. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones
55. p50 (cdc37) acting in concert with HSP90 is required for Raf-1 function
56. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of the heat shock protein 27
57. Interaction of heat-shock protein 70 with p53 translated in vitro: Evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation
58. Mitogen activation induces the enhanced synthesis of two heat-shock proteins in human lymphocytes
59. Different tumor-derived p53 mutants exhibit distinct biological activities
60. Expression of hsp70 induced in CHO cells by 45.0°C hyperthermia is cell cycle associated and DNA synthesis dependent
61. Differential regulation of HSC70, HSP70, HSP90, and HSP90β mRNA expression by mitogen activation and heat shock in human lymphocytes
62. Molecular chaperones in cellular protein folding
63. HSP90-mediated folding of the lymphoid cell kinase p56(1ck)
64. Association of HSP90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function
65. Modular folding and evidence for phosphorylation-induced stabilization of a HSP90-dependent kinase
66. Differential constitutive heat shock protein 70 expression during proliferation and differentiation of rat C6 glioma cells
67. Nuclear colocalization of c-myc protein and HSP70 in cells transfected with human wild-type and mutant c-myc genes
68. Decreased expression of the stress protein HSP70 is an early event in murine erytholeukemic cell differentiation
69. A role for the MEK/MAPK pathway in PNA-induced cell cycle arrest: Modulation of megakaryocytic differentiation of K562 cells
70. Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen
71. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein
72. Immunological evidence for the association of p53 with a heat shock protein, HSC70, in p53-plus-ras-transformed cell lines
73. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: A comparison of the 'hot spot' mutant phenotypes
74. Activity of the Hsp70 chaperone complex - DnaK, DnaJ, and GrpE in initiating phage λ DNA replication by sequestering and releasing P protein
75. Anti-sense inhibition of small-heat-shock-protein (HSP27) expression in MCF-7 mammary-carcinoma cells induces their spontaneous acquisition of a secretory phenotype
76. Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells
77. Protein kinases and phosphatases: The ying and yang of protein phosphorylation and signaling
78. Reconstitution of the multiprotein complex of pp 60src, HSP90 and p50 in a cell-free system
79. An interaction between p21(ras) and heat shock protein HSP60
80. Antibodies against 70-kDa heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins
81. 70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb
82. Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells
83. Nerve growth factor-mediated activation of the mitogen-activated protein (MAP) kinase cascade involves a signaling complex containing B-Raf and HSP90
84. Human major HSP70 protein complements the localization and functional defects of cytoplasmic mutant SV40 T antigen in Swiss 3T3 mouse fibroblast cells
85. Growth factors acting via tyrosine kinase receptors induce HSP90 α gene expression
86. Cell cycle regulation of the chicken hsp90a expression
87. Role of E2F in cell cycle control and cancer
88. Cyclins and cell cycle checkpoints
89. Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection
90. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest
91. Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein
92. Roles of Eschericha coli heat shock proteins DnaK, DnaJ and GrpE in mini-F plasmid replication
93. Expression of the small heat shock protein (HSP) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions
94. Simian virus 40 and polyoma virus induce synthesis of heat shock proteins in permissive cells
95. Cdc37 is a molecular chaperone with specific functions in signal transduction
96. Modification of growth in small heat shock (HSP27) gene transfected breast carcinoma
97. Increased expression of the M (r) 27,000 heat shock protein (HSP27) in in vitro differentiated normal human keratinocytes
98. Regulation of heat shock protein 70 gene expression by c-myc
99. Proteinprotein interactions between Epstein-Barr virus nuclear antigen-LP and cellular gene products. Binding of 70-kilodalton heat shock protein
100. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells
101. Heat shock-induced arrests in different cell cycle phases of rat C6-glioma cells are attennuated in heat shock-primed thermotolerant cells
102. Heat shock effects on cell cycle progression
103. Growth stimulating activity of heat shock protein 90 a to lymphoid cell lines in serum-free medium
104. Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II
105. Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle
106. Mechanism of regulation of HSP70 chaperones by DnaJ cochaperones
107. E2F target genes and cell cycle checkpoint control
108. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization
109. Cyclin D1 expression is regulated positively by the p42/p44(MAPK) and negatively by the p38/HOPG(MAPK) pathway
110. The small heat shock protein HSP27 increases invasiveness but decreases motility of breast cancer cells
111. Role of the Escherichia coli DnaK and DnaJ heat shock proteins in the initiation of bacteriophage λ DNA replication
112. The retinoblastoma gene family in differentiation and development
113. Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins
114. Human HSP70 and HSP40 chaperone proteins facilitate human papillomavirus-11 E1 protein binding to the origin and stimulate cell-free DNA replication
115. Evidence of an interaction between Mos and HSP70. A role of the Mos residue serine 3 in mediating HSP70 association
116. Cell cycle-dependent association of Gag-Mil and HSP90
117. Heat-shock cognate protein (HSC71) and related proteins in mouse spermatogenic cells
118. Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cells
119. Cloning of a hsp70-related gene expressed in mouse spermatids
120. Immunological evidence for the association between simian virus 40, 115-kDa super T antigen and HSP70 proteins in rat, monkey, and human cells
121. The serum-induced phosphorylation of mammalian HSP27 correlates with changes in its intracellular localization and levels of oligomerization
122. Cell cycle entry of mammalian fibroblasts is accompanied by the sustained activation of p44 MAPK and p42 MAPK isoforms in the G1 phase an their inactivation at the G1/S transition
123. HSP70 binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines
124. Expression of human HSP70 during the synthetic phase of the cell cycle
125. Cell cycle-dependent association of HSP70 with specific cellular proteins
126. Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins
127. Flexibility: The key to p53 function
128. p53 Is associated with p34(cdc2) in transformed cells
129. Polyubiquitination and proteasomal degradation of the p185(cerbB2) receptor protein-tyrosine kinase induced by geldanamycin
130. A MAP kinase dependent spindle assembly checkpoint in Xenopus egg extracts
131. Cyclin-dependent kinases. Engines, Clocks Microprocessors
132. Morphological analysis of germ cell apoptosis during postnatal testis development in normal and HSP70-2 knockout mice
133. Specific expression of HSP27 in human tumor cell lines in vitro
134. Conversion of epidermal growth factor (EGF) into a stimulatory ligand for A431-cell growth by herbimycin A by decreasing the level of expression of EGF receptor
135. Accelerated degradation of 160 kDa epidermal growth factor (EGF) receptor precursor by the tyrosine kinase inhibitor herbimycin A in the endoplasmatic reticulum of A431 human epidermoid carcinoma cells
136. Down modulation of N-myc, heat-shock protein 70, and nucleolin during the differentiation of human neuroblastoma cells
137. A pathway of multichaperone interactions common to diverse regulatory proteins: Estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsfl, and the aryl hydrocarbon receptor
138. 73-kDa heat shock cognate protein interacts directly with p27Kip1, a cyclin-dependent kinase inhibitor, during G1/S transition
139. Mutational analysis of HSP90 function. Interactions with a steroid receptor and a protein kinase
140. Induction of the synthesis of a 70, 000 dalton mammalian heat shock protein by the adenovirus E1A product
141. Demonstration of selective protein complexes of p53 with 73 kDa heat shock cognate protein, but not with 72 kDa heat shock protein in human tumor cells
142. Protein interaction of retinoblastoma gene product pRb110 with Mr 73,000 heat shock cognate protein
143. Biphasic translocation of a 70 kDa heat shock protein in human cytomegalovirus-infected cells
144. Accumulation of mutant p53 and HSP72 by heat treatment, and their association in a human glioblastoma cell line
145. 70-kDa Heat-shock cognate protein colocalizes with karyophilic proteins into the nucleus during their transport in vitro
146. A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein
147. Mitogen-activated protein kinases p42MAPK and p44MAPK are required for fibroblast proliferation
148. The function of heat-shock proteins in stress tolerance. Degradation and reactivation of damaged proteins
149. MAP kinase-dependent pathways in cell cycle control
150. A 50 kilodalton protein associated with Raf and pp 60 (v-Src) protein kinases is a mammalian homolog of the cell cycle control protein Cdc37
151. Identification of an HSP70-related protein associated with the centrosome from dinoflagellates to human cells
152. The regulation of cyclin-dependent kinase inhibitors (Ckis)
153. Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene through infection by DNA viruses
154. Specific interaction between the p53 cellular tumor antigen and major heat shock proteins
155. The role of the HSP90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase
156. The HSP90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
157. HSP70 is localized to the centrosome of dividing HeLa cells
158. Protein folding and the regulation of signaling pathways
159. Alteration of 53 conformation and induction of apoptosis in a murine erythroleukemia cell line by dimethylsulfoxide
160. What does Mos do in oocytes and somatic cells?
161. The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family
162. Heat shock proteins increase resistance to apoptosis
163. Induction of cellular hsp70 expression by human cytomegalovirus
164. The molecular chaperones in cell cycle control in 'Stress of Life. From Molecules to Man'
165. Cytokines and growth factors induce HSP27 phosphorylation in human astrocytes
166. Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells
167. Geldanamycin-induced destabilization of Raf-1 involves the proteasome
168. Disruption of the Raf-1-Hsp90 molecular complex results in detabilization of Raf-1 and loss of Raf-1 Ras association
169. Destabilization of Raf-1 by geldanamycin leads to disruptions of the Raf-1-MEK-mitogen-activated protein kinase signaling pathway
170. The MAPK signaling cascade
171. Tumor suppressor p53 gene forms multiple isoforms. Evidence for single locus origin and cytoplasmic complex formation with heat shock proteins
172. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell
173. Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases
174. Expresssion of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells
175. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function
176. The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate
177. In vivo nuclear transport kinetics in Saccharomyces cerevisiae: A role for heat shock protein 70 during targeting and translocation
178. p50 (cdc37) binds directly to the catalytic domain of Raf as well as to a site on HSP90 that is topologically adjacent to the tetratricopeptide repeat binding site
179. Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 12S E1A product
180. The cellular response to p53: The decision between life and death
181. Specific expression of heat shock protein HSPA2 in human male germ cells
182. 28-kDa mammalian heat shock protein, a novel substrate of a growth regulatory protease involved in differentiation of human leukemia cells
183. Heat shock protein 28 is a unique marker of growth arrest during macrophage differentiation of HL-60 cells
184. The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain
185. Raf exists in a native heterocomplex with HSP90 and p50 that can be reconstituted in a cell-free system
186. The HSP90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
187. Mammalian p50(Cdc37) is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
188. Kinase suppression of Ras forms a multiprotein signaling complex and modulates MEK localization
189. Gyrating protein kinases
190. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
191. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
192. Mutant p53 proteins bind HSP72/73 cellular heat shock-related proteins in SV40-transformed monkey cells
193. Interaction between HSP70 and HSP40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant-type p53
194. Augmented expression of HSP72 protein in normal human fibroblasts irradiated with ultraviolet light
195. Modulation of cell growth and mutation induction by introduction of the expression vector of human HSP70 gene
196. Human retinoblastoma protein (RB) is phosphorylated by Cdc2 kinase and MAP kinase in Xenopus maturing oocytes
197. c-myc Protein complex binds to two sites in human hsp70 promoter region
198. Elevated concentrations of the small stress protein HSP27 in rat renal tumors
199. Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells
200. Participation of Eschericha coli heat shock proteins DnaJ, DnaK, and GrpE in P1 plasmid replication
201. Regulation of transcription by MAP kinase cascades
202. Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus
203. Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A
204. Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: Reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1
205. The heat shock protein 83 (HSP83) is required for Raf-mediated signaling in Drosophila
206. Oncogenic potential of Hsp72
207. NIH 3T. 3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein
208. Inactivation of tumor suppressor p53 by Mot-2, a HSP70 family member
209. Induction of stress proteins in human endothelial cells by heavy metal ions and heat shock
210. Modulation of stress protein (HSP27 and HSP70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1
211. Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein
212. The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex
213. Mitogen and stress response pathways. MAP kinase cascades and phosphatase regulation in mammals and yeast
214. Inhibition of proliferation and induction of apoptosis by abrogation of heat shock protein (HSP) 70 expression in tumor cells
215. Small heat shock protein family: Function Health Disease
216. A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (HSP90) is the same protein complexed with pp 60v-src HSP90 in cells transformed by the Rous sarcoma virus
217. Inhibition of heat shock protein HSP90-pp. 60(vsrc) heteroprotein complex formation by benzoquinone ansamycins. Essential role for stress proteins in oncogenic transformation
218. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
219. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, a HSP90-binding agent
220. Replication of mini-P1 plasmid DNA in vitro requires two initiation proteins, encoded by the repA gene of phage P1 and the dnaA gene of Escherichia coli
221. Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA
222. Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin
223. DnaJ, DnaK and GrpE heat shock proteins are required in oriP1 DNA replication solely at the RepA monomerization step
224. The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene
225. Transcription of the human hsp70 genes is induced by serum stimulation
226. Function of the GrpE heat shock protein in bidirectional unwinding and replication from the origin of phage λ
227. Heat-shock protein HSP90 governs the activity of pp 60(vsrc) kinase
228. Maturation of the tyrosine kinase c-Src as a kinase and as a substrate depends on the molecular chaperone HSP90
229. Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen
230. Expression and roles of heat shock proteins in human breast cancer
231. Expression of HSP90 and cyclin D1 in human breast cancer
232. The gene for the rat heat-shock cognate, hsc70, can suppress oncogene-mediated transformation
233. Retinoic acid induced mitogen-activated protein (MAP) extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest
234. High constitutive expression of heat shock protein 90 a in human acute leukemia cells
235. Developmental-stage-specific expression of the hsp70 gene family during differentiation of the mammalian male germ line
236. Identification and sequence analysis of a new member of the mouse hsp70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line
237. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins
238. Mammalian mitogen-activated kinase pathways are regulated through formation of specific kinase-activator complexes
239. Nuclear translocation of stress protein HSC70 during S phase in rat C6-glioma cells
240. Correlation between the conformational phenotype of p53 and its subcellular location
241. Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells
242. HSP702 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes
243. Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products
244. Initiation of λ DNA replication with purified host- and bacteriophage-encoded proteins: The dnaK, dnaJ and grpE heat shock proteins