Hsp27 as a negative regulator of cytochrome c release

Molecular and Cellular Biology

Volumn 22, Issue 3, 2002, Pages 816-834

  Paul, Catherine ^a   Manero, Florence ^a   Gonin, Sandrine ^a   Kretz Remy, Carole ^a   Virot, Sophie ^a   Arrigo, André Patrick ^a  

^a CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOCHALASIN D; CYTOCHROME C OXIDASE; ETOPOSIDE; F ACTIN; HEAT SHOCK PROTEIN 27; PHALLOIDIN; STAUROSPORINE;

ACTIN FILAMENT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPOLYMERIZATION; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOLECULAR MECHANICS; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALIA; MURINAE;

EID: 0036143720     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.3.816-834.2002     Document Type: Article

References (84)

1. Expression and function of the low-molecular-weight heat shock proteins
2. Small stress proteins: Chaperones that act as regulators of intracellular redox state and programmed cell death
3. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the apaf-1 apoptosome
4. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity
5. A role for heat shock protein 27 in CTL-mediated cell death
6. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
7. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
8. Actin is cleaved during constitutive apoptosis
9. Hsp27 negatively regulates cell death by interacting with cytochrome c
10. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo
11. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
12. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
13. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
14. HSP27 inhibits cytochrome c-dependent activation of procaspase-9
15. Heat shock protein 27 enhances the tumor-igenicity of immunogenic rat colon carcinoma cell clones
16. HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs
17. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
18. Mitochondria and apoptosis
19. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
20. Bcl-2 and Hsp27 act at different levels to suppress programmed cell death
21. Bcl2 is the guardian of microtubule integrity
22. Cif (cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid
23. Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells
24. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
25. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
26. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
27. HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress
28. Over-expression of Hsp70 confers tumorigenicity to mouse fibrosarcoma cells
29. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
30. Small heat shock proteins are molecular chaperones
31. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
32. Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis
33. Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro
34. Induction of chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock
35. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27
36. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
37. Actin polymerization and depolymerization during apoptosis in HL-60 cells
38. Heat shock protein 70 inhibits downstream of cytochrome c release and upstream of caspase-3 activation
39. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
40. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
41. Stabilization of F-actin by phalloidin. Reversal of the destabilizing effect of cytochalasin B
42. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
43. Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cells
44. The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
45. Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis
46. Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFα in NIH-3T3-ras cells
47. Hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells
48. Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts
49. Human hsp27, Drosophila hsp27 and human αB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these protein against TNFα-induced cell death
50. Small stress proteins as novel regulators of apoptosis: Heat shock protein 27 blocks Fas/APO-1-and staurosporine-induced cell death
51. Bcl-2 gene family in the nervous system
52. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein
53. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
54. Caspases: Killer proteases
55. Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3
56. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90
57. Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibro-blasts exposed to menadione or staurosporine
58. Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25
59. Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery
60. Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death
61. Cytochrome c: Can't live with it-can't live without it
62. Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation
63. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
64. Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region
65. Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells
66. Heat shock proteins increase resistance to apoptosis
67. Small heat shock proteins protect mitochondria of thermotolerant cells
68. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
69. Mitochondrial release of caspase-2 and -9 during the apoptotic process
70. Molecular characterization of mitochondrial apoptosis-inducing factor
71. BAG-1 modulates the chaperone activity of Hsp70/Hsc70
72. The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells
73. Caspases: Enemies within
74. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
75. F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells
76. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
77. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
78. Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector
79. Movement of Bax from the cytosol to mitochondria during apoptosis
80. Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis
81. Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro
82. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
83. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
84. Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their condensation, formation of outer membrane discontinuities and reduction in inner membrane potential