The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

Cell Death and Differentiation

Volumn 9, Issue 1, 2002, Pages 20-26

  van Loo, G ^a   van Gurp, M ^a   Depuydt, B ^a   Srinivasula, S M ^b   Rodriguez, I ^c   Alnemri, E S ^b   Gevaert, K ^a   Vandekerckhove, J ^a   Declercq, W ^a   Vandenabeele, P ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; HtrA2; Mitochondria; Omi; Serine protease; tBid

Indexed keywords

CASPASE; CASPASE INHIBITOR; CELL EXTRACT; FAS ANTIBODY; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2; PROTEIN BID; PROTEOME; RECOMBINANT PROTEIN; SERINE PROTEINASE; SERINE PROTEINASE OMI; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOSOL; DYING; ENZYME ACTIVITY; ENZYME RELEASE; EXPOSURE; FIBROSARCOMA; IN VIVO STUDY; LIVER; MITOCHONDRION; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASES; CELLS, CULTURED; CYTOSOL; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PROTEINS; SERINE ENDOPEPTIDASES; TRANSLOCATION, GENETIC; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

ANIMALIA; MUS MUSCULUS;

EID: 18244386261     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400970     Document Type: Article

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