Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function

Cancer Research

Volumn 60, Issue 24, 2000, Pages 6818-6821

  Wadhwa, Renu ^a   Sugihara, Takashi ^a   Yoshida, Akiko ^a   Nomura, Hitoshi ^a   Reddel, Roger R ^b   Simpson, Richard ^c   Maruta, Hiroshi ^c   Kaul, Sunil C ^d  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^d NATL INST BIOSCI HUM TECHNOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; HEAT SHOCK PROTEIN 70; PROTEIN P53;

ANIMAL CELL; ARTICLE; CANCER CELL; CERCOPITHECIDAE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TOXICITY;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, AFFINITY; COLORING AGENTS; CYTOPLASM; GENES, REPORTER; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; PRECIPITIN TESTS; PROTEIN BINDING; PYRIDINES; THIAZOLES; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034671731     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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