Shape-dependent control of cell growth, differentiation, and apoptosis: Switching between attractors in cell regulatory networks

Experimental Cell Research

Volumn 261, Issue 1, 2000, Pages 91-103

  Huang, Sui ^a   Ingber, Donald E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Boolean networks; Cell shape; Cytoskeleton; Signal transduction

Indexed keywords

DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; RAF PROTEIN; RAS PROTEIN; RETINOBLASTOMA PROTEIN; RHO FACTOR;

ANIMAL CELL; APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CELL SHAPE; CELL SURVIVAL; COMPUTER SIMULATION; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE C H RAS; ONCOGENE C MYC; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034715919     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5044     Document Type: Article

References (102)

1. The structural and mechanical complexity of cell-growth control
2. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOG-MAPK pathway
3. Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade
4. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
5. Control of the ERK MAP kinase cascade by Ras and Raf
6. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
7. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
8. R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism
9. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras
10. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
11. Growth factor signaling: Where is the specificity?
12. Mammalian MAP kinase modules: How to transduce specific signals
13. Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro
14. Role of basal lamina in neoplastic disorganization of tissue architecture
15. Integrin signaling
16. Extracellular matrix signaling: Integration of form and function in normal and malignant cells
17. Extracellular matrix remodelling and cellular differentiation
18. Cell adhesion molecules, signal transduction and cell growth
19. Integrins and anoikis
20. Cell anchorage permits efficient signal transduction between ras and its downstream kinases
21. Integrin-dependent activation of MAP kinase: A link to shape-dependent cell proliferation
22. Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2
23. Integrins, oncogenes, and anchorage independence
24. Engineering cell shape and function
25. Geometric control of cell life and death
26. Cell-shape-dependent control of p27Kip and cell cycle progression in human capillary endothelial cells
27. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates
28. Role of cell shape in growth control
29. Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells
30. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes
31. Switching from differentiation to growth in hepatocytes: Control by extracellular matrix
32. Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis
33. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
34. Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression
35. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
36. Extracellular matrix and pulmonary hypertension: Control of vascular smooth muscle cell contractility
37. Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions
38. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
39. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E
40. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
41. Translation and the cytoskeleton: A mechanism for targeted protein synthesis
42. Single mRNAs visualized by ultrastructural in situ hybridization are principally localized at actin filament intersections in fibroblasts
43. Comparison of the complete protein sets of worm and yeast: Orthology and divergence
44. The coming Kuhnian revolution in biology
45. Self-organization, complexity and chaos: The new biology for medicine
46. Gene expression profiling, genetic networks and cellular states: An integrating concept for tumorigenesis and drug discovery
47. Do we understand development?
48. Evolvability
49. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA
50. Inhibition of tyrosine phosphatases induces apoptosis independent from the CD95 system
51. Dimethyl sulphoxide: A review of its applications in cell biology
52. Polar solvents: A novel class of antineoplastic agents
53. Ethanol as an enhancer of neural differentiation
54. Morphological potential of Phaeococcomyces sp (strain ?h 49) - A typical representative of microcolonial lithobiontic fungi
55. Ethanol exposure stimulates cartilage differentiation by embryonic limb mesenchyme cells
56. Modelling the complexity of genetic networks: Understanding multigenic and pleiotropic regulation
57. Dynamical behaviour of biological regulatory networks. I. Biological role of feedback loops and practical use of the concept of loop-characteristic state
58. The strategy of growth
59. Induction of p21 (WAF-1/CIP1) during differentiation
60. p53-Independent expression of p21Cip1 in muscle and other terminally differentiating cells
61. MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells
62. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells
63. Cell cycle exit upon myogenic differentiation
64. Insights into the transcriptional control of adipocyte differentiation
65. Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts
66. Kinetics of G1 transit following brief starvation for serum factors
67. Social controls on cell survival and cell death
68. A matter of life and cell death
69. Apoptosis and cell division
70. Molecular switches that govern the balance between proliferation and apoptosis
71. Error and attack tolerance of complex networks
72. Gene expression informatics - It's all in your mine
73. Proteomic analysis
74. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16 INK4a
75. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1
76. Regulation of immune responses by NF-kappa B/Rel transcription factor
77. Pro-inflammatory signaling: Last pieces in the NF-kappaB puzzle?
78. NF-kappaB as a primary regulator of the stress response
79. Janus faces of NF-kB: Neurodestruction versus neuroprotection
80. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
81. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
82. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
83. Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway
84. The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells: Dependence on the availability of downstream targets
85. Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic β-cells
86. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
87. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
88. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
89. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway
90. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
91. An essential role for Rho, Rac, and Cdc42 ATPases in cell cycle progression through G1
92. Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway
93. Rb function in cellcycle regulation and apoptosis
94. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
95. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
96. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo
97. p38 Mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation
98. Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis
99. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4