Identification of heat shock protein 60 as a molecular mediator of α3 β1 integrin activation

Cancer Research

Volumn 62, Issue 5, 2002, Pages 1541-1548

  Barazi, Heba O ^a   Zhou, Longen ^a   Templeton, Nancy Smyth ^b   Krutzsch, Henry C ^a   Roberts, David D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 60; INTEGRIN; MEMBRANE PROTEIN; MIZORIBINE; PROTEIN ANTIBODY; RECOMBINANT PROTEIN; SOMATOMEDIN C; THROMBOPLASTIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CELL ADHESION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LYMPH NODE; MASS SPECTROMETRY; METASTASIS; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TWO DIMENSIONAL ELECTROPHORESIS;

CHAPERONIN 60; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTEGRIN ALPHA3BETA1; INTEGRINS; MACROLIDES; MOLECULAR WEIGHT; PRECIPITIN TESTS; RECOMBINANT PROTEINS; RIBONUCLEOSIDES; TUMOR CELLS, CULTURED;

EID: 0036494362     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis
2. Maspin suppresses the invasive phenotype of human breast carcinoma
3. Site-specific experimental metastasis patterns of two human breast cancer cell lines in nude rats
4. Identification of integrin α3β 1 as a neuronal thrombospondin receptor mediating neurite outgrowth
5. Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by α3β1 integrin and regulated by insulin-like growth factor-1 and CD98
6. Identification of an α3β1 integrin recognition sequence in thrombospondin-1
7. Thrombospondin-1 promotes α3β1 integrin-mediated adhesion and neurite-like outgrowth and inhibits proliferation of small cell lung carcinoma cells
8. Integrin α3β1 can promote adhesion and spreading of metastatic breast carcinoma cells on the lymph node stroma
9. The role of α2 β1 and α3β1 integrin receptors in the initial anchoring of MDA-MB-231 human breast cancer cells to cortical bone matrix
10. Bidirectional signaling between the cytoskeleton and integrins
11. Bi-directional signal transduction by integrin receptors
12. Integrin signaling
13. Recent insights into the role of integrins in cancer metastasis
14. The role of integrins in tumorigenesis and metastasis
15. The biochemistry of cancer dissemination
16. Sequential steps in hematogenous metastasis of cancer cells studied by in vivo videomicroscopy
17. The dynamic regulation of integrin adhesiveness
18. Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes
19. Integrin cytoplasmic domains mediate inside-out signal transduction
20. Modulation of the affinity of integrin αIIb β3 (GPIIb-IIIa) by the cytoplasmic domain of αIIb
21. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling
22. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
23. Integrin-linked kinase and PINCH: Partners in regulation of cell-extracellular matrix interaction and signal transduction
24. Inducible tyrosine phosphorylation of the β3 integrin requires the αV integrin cytoplasmic tail
25. Outside-in integrin signal transduction. αIIb β3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation
26. Requirement of integrin β3 tyrosine 747 for β3 tyrosine phosphorylation and regulation of αvβ3 avidity
27. Interaction of focal adhesion kinase with cytoskeletal protein talin
28. An interaction between α-actinin and the β1 integrin subunit in vitro
29. A potential link between the cytoskeleton and signal transduction
30. Direct interaction of filamin (ABP-280) with the β 2-integrin subunit CD 18
31. Adhesion plaques: Sites of transmembrane interaction between the extracellular matrix and the actin cytoskeleton
32. Molecular interactions in cell adhesion complexes
33. Inducible interaction of integrin α2β1 with calreticulin. Dependence on the activation state of the integrin
34. Calreticulin-integrin bidirectional signaling complex
35. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: Cell distribution and antigenic relation to components on resting cells and T cell lines
36. Purification of thrombospondin from human platelets
37. The interaction of plasma fibronectin with fibroblastic cells in suspension
38. Recombinant soluble human α3β1 integrin: Purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner
39. Platelet thrombospondin mediates attachment and spreading of human melanoma cells
40. Integrin α3β1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells
41. Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components
42. The roles of integrins and extracellular matrix proteins in the insulin-like growth factor l-stimulated chemotaxis of human breast cancer cells
43. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells
44. Fibronectin and integrins in invasion and metastasis
45. Vitronectin and its receptors
46. Mammalian HSP60 is a major target for an immunosuppressant mizoribine
47. Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine
48. Identification of mitochondrial proteins and some of their precursors in two-dimensional electrophoretic maps of human cells
49. Chaperone-mediated protein folding
50. Structure and function in GroEL-mediated protein folding
51. The Hsp70 and Hsp60 chaperone machines
52. Mitochondrial-matrix proteins at unexpected locations: Are they exported?
53. Identification of endoplasmic reticulum in the primitive eukaryote Giardia lamblia using cryoelectron microscopy and antibody to Bin
54. Recognition by human V γ 9/V δ 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells
55. Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells
56. Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells
57. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen
58. Association of HSP60-like proteins with the L-system amino acid transporter
59. An interaction between p21ras and heat shock protein hsp60, a chaperonin
60. Enhancement in amount of P1 (hsp60) in mutants of Chinese hamster ovary (CHO-K1) cells exhibiting increases in the A system of amino acid transport
61. Cutting edge: Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells
62. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
63. Staphylococcal fibronectin binding protein interacts with heat shock protein 60 and integrins: Role in internalization by epithelial cells
64. Control of src kinase activity by activators, inhibitors, and substrate chaperones
65. Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane
66. Highly stoichiometric, stable, and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration
67. Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/ PETA-3 with α3β1 integrin localized at endothelial lateral junctions
68. Modulation of epidermal differentiation by epiligrin and integrin α3β1
69. RhoA-dependent switch between α2β1 and α3β1 integrins is induced by laminin-5 during early stage of HT-29 cell differentiation
70. Function of α3β1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2)
71. Cell contact-dependent activation of α3β1 integrin modulates endothelial cell responses to thrombospondin-1