Hsp90: Chaperoning signal transduction

Journal of Cellular Physiology

Volumn 188, Issue 3, 2001, Pages 281-290

  Richter, Klaus ^a   Buchner, Johannes ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RADICICOL; TRANSCRIPTION FACTOR;

ENZYME ACTIVITY; ENZYME SUBSTRATE; EUKARYOTE; HORMONE RECEPTOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; ANIMALS; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MODELS, MOLECULAR; PHOSPHOTRANSFERASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 0034892432     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.1131     Document Type: Review

References (120)

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5. Mutant conformation of p53 translated in vitro or in vivo requires functional Hsp90
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7. Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center
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10. A holding for folding
11. Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin
12. The common 90-kd protein component of non-transformed '8S' steroid receptors is a heat-shock protein
13. Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
14. Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52, and FKBP51 with Hsp90 mutants
15. v-src to the plasma membrane
16. Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila
17. Direct evidence that the glucocorticoide receptor binds to hsp90 at or near the termination of receptor translation in vitro
18. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
19. The Mr approximately 90,000 heat shock protein: An important modulator of ligand and DNA-binding properties of the glucocorticoid receptor
20. Translation of glucocorticoide receptors in vitro yields a nonactivated protein
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23. The steroid and thyroid hormone receptor superfamily
24. Heat shock-regulated production of Escherichia coli beta-galactosidase in Saccharomyces cerevisiae
25. The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding
26. Dynamic activation of endothelial nitric oxide synthase by Hsp90
27. CYP2E1 degradation by in vitro reconstituted systems: Role of the molecular chaperone hsp90
28. The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
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30. Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function
31. Hsp90-mediated folding of the lymphoid cell kinase p561ck
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33. Some effects of growth conditions on steady state and heat shock induced htpG gene expression in continuous cultures of Escherichia coli
34. Functional requirement of p23 and Hsp90 in telomerase complexes
35. Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase
36. The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocerticoid receptor into a functional heterocomplex with hsp90
37. Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo
38. Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones
39. A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23
40. Binding of p23 and hsp90 during assembly with the progesterone receptor
41. Characterization of a novel 23 kDa protein of unreactive progesterone receptor complexes
42. The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes
43. Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains
44. Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation
45. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases
46. Temperature-sensitive mutants of hsp82 of the budding yeast Saccharomyces cerevisiae
47. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation
48. Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins
49. Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome
50. Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast
51. Cell cycle-dependent association of Gag-Mil and hsp90
52. Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties
53. The basic helix-loop-helix/PAS factor Sim is associated with hsp90. Implications for regulation by interaction with partner factors
54. Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins
55. Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
56. The 90-kDa heat shock protein, Hsp90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity
57. Regulation of pim-1 by hsp90
58. Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket
59. Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 Heterocomplexes
60. The complexity of Raf-1 regulation
61. Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases
62. Mutational analysis of Hsp90 function: Interactions with a steroid receptor and a protein kinase
63. Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a saccharomyces cerevisiae Hsp90 loss-of-function mutation
64. The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor
65. The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase
66. A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein
67. Interaction of the calcium and calmodulin regulated eEF-2 kinase with heat shock protein 90
68. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
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70. Evidence that the 90 kDa heat shock protein (hsp90) exists in cytosol in heteromeric complexes containing hsp70 and three other proteins with Mr of 63000, 56000, and 50000
71. A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37
72. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52, and Cyp40
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74. Steroide receptor interactions with heat-shock protein and immunophilin chaperones
75. A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90
76. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
77. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
78. The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains
79. Mineralocorticosteroid receptor of the chick intestine. Oligomeric structure and transformation
80. Overlapping sites of tetratricopeptide repeat protein binding and chaperone activity in heat shock protein 90
81. Subunit composition of the molybdate-stabilized "8-9 S" nontransformed estradiol receptor purified from calf uterus
82. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
83. The 90 kDa peptide of the heine-regulated eIF-2 alpha kinase has sequence similarity with the 90 kDa heat shock protein
84. Hsp90 as a capacitor for morphological evolution
85. Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein
86. Demonstration that the 90 kDa heat shock protein is bound to the glucocorticoid receptor in its 9S nondeoxynucleic acid binding form
87. ATP-binding properties of human Hsp90
88. Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence
89. The charged region of Hsp90 modulates the function of the N-terminal domain
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91. Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
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93. Disruption of the Raf-1-hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association
94. Geldanamycin-induced destabilization of Raf-1 involves the proteasome
95. Structural and functional aspects of basic helix-loop-helix protein folding by heat-shock protein 90
96. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin
97. p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site
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99. Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins
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101. Assembly of progesterone receptor with heat-shock proteins and receptor activation are ATP mediated events
102. Two FKBP-related proteins are associated with progesterone receptor complexes
103. Identification of a 60 kDa stress-related protein, p60, which interacts with hsp90 and hsp70
104. Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest
105. Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system
106. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signalling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
107. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
108. Kinase supressor of Ras forms a multiprotein signaling complex and modulates MEK localization
109. Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis
110. Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A
111. v-src
112. C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle
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116. Crystal structure of an N-terminal fragment of the DNA gyrase B protein
117. 9S binding protein for androgens and progesterone
118. Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23
119. In vitro evidence that hsp90 contains two independent chaperone sites
120. Association of the heat shock protein hsp90 with steroid hormone receptors and tyrosine kinase oncogene products