What's in the 'BAG'? - A functional domain analysis of the BAG-family proteins

Cancer Letters

Volumn 188, Issue 1-2, 2002, Pages 25-32

  Doong, Howard ^a   Vrailas, Alysia ^a   Kohn, Elise C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; BcL 2; Chaperone; Hsp70; Migration; Proliferation; Silencer of death domains; Stress response; Survival

Indexed keywords

BAG 1 PROTEIN; CASPASE; HEAT SHOCK PROTEIN 70; PROTEIN BAG; PROTEIN BAG 1L; PROTEIN BAG 1M; PROTEIN BAG 1S; PROTEIN BAG 3; PROTEIN BAG 4; PROTEIN BAG 6; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID COMPOSITION; APOPTOSIS; BREAST CARCINOMA; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVITY; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; APOPTOSIS; CARRIER PROTEINS; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

EID: 0037114358     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00456-1     Document Type: Short Survey

References (53)

1. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J.A., Reed J.C. Cloning and functional analysis of BAG-1: a novel bcl-2-binding protein with anti-cell death activity. Cell. 80:1995;279-284.
2. Lee J., Takahashi T., Yasuhara N., Inazawa J., Kamada S., Tsujimoto Y. Bis, a bcl-2-binding protein that synergizes with bcl-2 in preventing cell death. Oncogene. 18:1999;6183-6190.
3. Takayama S., Bimston D.N., Matsuzawa S., Freeman B.C., Aime-Sempe C., Xie Z., Morimoto R.I., Reed J.C. BAG-1 modulates the chaperone activity of hsp70/hsc70. EMBO J. 16:1997;4887-4896.
4. Takayama S., Xie Z., Reed J.C. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J. Biol. Chem. 274:1999;781-786.
5. Thress K., Henzel W., Shillinglaw W., Kornbluth S. Scythe: a novel reaper-binding apoptotic regulator. EMBO J. 17:1998;6135-6143.
6. Moribe Y., Niimi T., Yamashita O., Yaginuma T., Samui. A novel cold-inducible gene, encoding a protein with a BAG domain similar to silencer of death domains (SODD/BAG-4), isolated from bombyx diapause eggs. Eur. J. Biochem. 268:2001;3432-3442.
7. Briknarova K., Takayama S., Brive L., Havert M.L., Knee D.A., Velasco J., Homma S., Cabezas E., Stuart J., Hoyt D.W., Satterthwait A.C., Linas M., Reed J.C., Ely K.R. Structural analysis of BAG-1 cochaperone and its interactions with Hsc70 heat shock protein. Nat. Struct. Biol. 8:2001;349-352.
8. Takayama S., Reed J.C. Molecular chaperone targeting and regulation by BAG family proteins. Nat. Cell. Biol. 3:2001;237-241.
9. Liu R., Takayama S., Zheng Y., Froesch B., Chen G., Zhang X., Reed J.C., Zhang X. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. J. Biol. Chem. 273:1998;16985-16992.
10. Takayama S., Krajewska S., Kitada S., Zapata J.M., Kochel K., Knee D., Scudiero D., Tudor G., Miller G.J., Miyashita T., Yamada M., Reed J.C. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Cancer Res. 58:1998;3116-3131.
11. Doong H., Price J., Kim Y.S., Gasbarre C., Probst J., Liotta L.A., Blanchette J., Rizzo K., Kohn E. CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase c-gamma and hsp70/hsc70. Oncogene. 19:2000;4385-4395.
12. Jiang Y., Woronicz J.D., Liu W., Goeddel D.V. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science. 283:1999;543-546.
13. Antoku K., Maser R.S., Scully W.J. Jr, Delach S.M., Johnson D.E. Isolation of bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem. Biophys. Res. Commun. 286:2001;1003-1010.
14. Miki K., Eddy E.M. Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain. Mol. Cell. Biol. 22:2002;2536-2543.
15. Ozaki T., Hanaoka E., Naka M., Nakagawara A., Sakiyama S. Cloning and characterization of rat BAT3 cDNA. DNA Cell Biol. 18:1999;503-512.
16. Thress K., Evans E.K., Kornbluth S. Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity. EMBO J. 18:1999;5486-5493.
17. Manchen S.T., Hubberstey A.V. Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis. Biochem. Biophys. Res. Commun. 287:2001;1075-1082.
18. Sondermann H., Scheufler C., Schneider C., Hohfeld J., Ulrich-Hartl F., Moarefi I. Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science. 291:2001;1553-1557.
19. Song J., Takeda M., Morimoto R.I. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat. Cell Biol. 3:2001;276-282.
20. Stuart J.K., Myszka D.G., Joss L., Mitchell R.S., McDonald S.M., Xie Z., Takayama S., Reed J.C., Ely K.R. Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones. J. Biol. Chem. 273:1998;22506-22514.
21. Hohfeld J., Jentsch S. GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16:1997;6209-6216.
22. Bimston D., Song J., Winchester D., Takayama S., Reed J.C., Morimoto R.I. BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J. 17:1998;6871-6878.
23. Thress K., Song J., Morimoto R.I., Kornbluth S. Reversible inhibition of Hsp70 chaperone function by Scythe and reaper. EMBO J. 20:2001;1033-1041.
24. Wang H., Takayama S., Rapp U.R., Reed J.C. Bcl-2 interacting protein, BAG-1 binds to and activates the kinase Raf-1. Proc. Natl Acad. Sci. USA. 93:1996;7063-7068.
25. Kudoh M., Knee D.A., Takayama S., Reed J.C. Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells. Cancer Res. 62:2002;1904-1909.
26. Ozawa F., Friess H., Zimmermann A., Kleeff J., Buchler M.W. Enhanced expression of silencer of death domains (SODD/BAG-4) in pancreatic cancer. Biochem. Biophys. Res. Commun. 271:2000;409-413.
27. Luders J., Demand J., Hohfeld J. The ubiquitin-related BAG-1 provides a link between the molecular chaparones Hsc70/Hsp70 and the proteasome. J. Biol. Chem. 275:2000;4613-4617.
28. Brimmell M., Burns J.S., Munson P., McDonald L., O'Hare M.J., Lakhani S.R., Packham G. High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers. Br. J. Cancer. 81:1999;1042-1051.
29. Connell P., Ballinger C.A., Jiang J., Wu Y., Thompson L.J., Hohfeld J., Patterson C. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat. Cell Biol. 3:2001;93-96.
30. Demand J., Alberti S., Patterson C., Hohfeld J. Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr. Biol. 11:2001;1569-1577.
31. Jiang J., Ballinger C.A., Wu Y., Dai Q., Cyr D.M., Hohfeld J., Patterson C. CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J. Biol. Chem. 276:2001;42938-42944.
32. Murata S., Minami Y., Minami M., Chiba T., Tanaka K. CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep. 2:2001;1133-1138.
33. Kalderon D., Roberts B.L., Richardson W.D., Smith A.E. A short amino acid sequence able to specify nuclear location. Cell. 39:1984;499-509.
34. Robbins J., Dilworth S.M., Laskey R.A., Dingwall C. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell. 64:1991;615-623.
35. Zeiner M., Gehring U. A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc. Natl. Acad. Sci. USA. 92:1995;11465-11469.
36. Packham G., Brimmell M., Cleveland J.L. Mammalian cells express two differently localized BAG-1 isoforms generated by alternative translation initiation. Biochem. J. 328:1997;807-813.
37. Sparks A.B., Rider J.E., Hoffman N.G., Fowlkes D.M., Quilliam L.A., Kay B.K. Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk and Grb2. Proc. Natl Acad. Sci. USA. 93:1996;1540-1544.
38. Williamson M.P. The structure and funciton of proline-rich regions in proteins. Biochem. J. 227:1994;249-260.
39. Pawson T., Scott J.D. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:1997;2075-2080.
40. Liao Q., Ozawa F., Friess H., Zimmermann A., Takayama S., Reed J.C., Kleeff J., Buchler M.W. The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett. 503:2001;151-157.
41. Chattopadhyay A., Carpenter G. PLC-gamma1 is required for IGF-1 protection from cell death induced by loss of extracellular matrix adhesion. J. Cell. Sci. 115:2002;2233-2239.
42. Sudol M. Structure and function of the WW domain. Prog. Biophys. Mol. Biol. 65:1996;113-132.
43. Ilsley J.L., Sudol M., Winder S.J. The WW domain: linking cell signaling to the membrane cytoskeleton. Cell. Signal. 14:2002;183-189.
44. Witcher M., Yang X., Pater A., Tang S. BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway. Exp. Cell Res. 265:2001;167-173.
45. Guzey M., Takayama S., Reed J.C. BAG-1L enhances trans-activation function of the vitamin D receptor. J. Biol. Chem. 275:2000;40749-40756.
46. Froesch B.A., Takayama S., Reed J.C. BAG-1L protein enhances androgen receptor function. J. Biol. Chem. 273:1998;11660-11666.
47. Tang S., Shaheta N., Chernenko G., Khalifa M., Wang X. Expression of BAG-1 in invasive breast carcinomas. J. Clin. Oncol. 17:1999;1710-1719.
48. Turner B.C., Krajewski S., Krajewska M., Takayama S., Gumbs A.A., Carter D., Rebbeck T.R., Haffty B.G., Reed J.C. BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. J. Clin. Oncol. 19:2001;992-1000.
49. Yamauchi H., Adachi M., Sakata K., Hareyama M., Satoh M., Himi T., Takayama S., Reed J.C., Imai K. Nuclear BAG-1 localization and the risk of recurrence after radiation therapy in laryngeal carcinomas. Cancer Lett. 165:2001;103-110.
50. Townsend P.A., Dublin E., Hart I.R., Kao R.H., Hanby A.M., Cutress R.I., Poulsom R., Ryder K., Barnes D.M., Packham G. BAG-1 expression in human breast cancer: interrelationship between BAG-1 RNA, protein, Hsc70 and clinico-pathological data. J. Pathol. 197:2002;51-59.
51. Naishiro Y., Adachi M., Okuda H., Yawata A., Mitaka T., Takayama S., Reed J.C., Hinoda Y., Imai K. BAG-1 accelerates cell motility of human gastric cells. Oncogene. 18:1999;3244-3251.
52. Kanelakis K.C., Morishima Y., Dittmar K.D., Galigniana M.D., Takayama S., Reed J.C., Pratt W.B. Differential effects of the Hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the Hsp90-based chaperone machinery. J. Biol. Chem. 274:1999;34134-34140.
53. Bardelli A., Longati P., Albero D., Goruppi S., Schneider C., Ponzetto C., Comoglio P.M. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J. 15:1996;6205-6212.