Cdc37 enhances proliferation and is necessary for normal human prostate epithelial cell survival

Cancer Research

Volumn 63, Issue 15, 2003, Pages 4614-4619

  Schwarze, Steven R ^a   Fu, Vivian X ^a   Jarrard, David F ^a,b  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 37; CHAPERONE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; HEAT SHOCK PROTEIN 70; PROTEIN P16; RAF PROTEIN; RAF1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVITY; GENE OVEREXPRESSION; GROWTH REGULATION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; PROTEIN FOLDING; PROTEIN FUNCTION;

APOPTOSIS; BROMODEOXYURIDINE; CELL CYCLE PROTEINS; CELL DIVISION; CELL SURVIVAL; CHAPERONINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DISEASE PROGRESSION; DROSOPHILA PROTEINS; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; MALE; MOLECULAR CHAPERONES; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF;

EID: 0042635840     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Stepanova, L., Yang, G., DeMayo, F., Wheeler, T. M., Finegold, M., Thompson, T. C., and Harper, J. W. Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene, 19: 2186-2193, 2000.
2. Stepanova, L., Finegold, M., DeMayo, F., Schmidt, E. V., and Harper, J. W. The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. Mol. Cell. Biol., 20: 4462-4473, 2000.
3. Prodromou, C., Siligardi, G., O'Brien, R., Woolfson, D. N., Regan, L., Panaretou, B., Ladbury, J. E., Piper, P. W., and Pearl, L. H. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J., 18: 754-762, 1999.
4. Kimura, Y., Rutherford, S. L., Miyata, Y., Yahara, I., Freeman, B. C., Yue, L., Morimoto, R. I., and Lindquist, S. Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes Dev., 11: 1775-1785, 1997.
5. Stepanova, L., Leng, X., and Harper, J. W. Analysis of mammalian Cdc37, a protein kinase targeting subunit of heat shock protein 90. Methods Enzymol., 283: 220-229, 1997.
6. Hartson, S. D., Irwin, A. D., Shao, J., Scroggins, B. T., Volk, L., Huang, W., and Matts, R. L. p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. Biochemistry, 39: 7631-7644, 2000.
7. Grammatikakis, N., Lin, J. H., Grammatikakis, A., Tsichlis, P. N., and Cochran, B. H. p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol. Cell. Biol., 19: 1661-1672, 1999.
8. Shao, J., Grammatikakis, N., Scroggins, B. T., Uma, S., Huang, W., Chen, J. J., Hartson, S. D., and Matts, R. L. Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase. J. Biol. Chem., 276: 206-214, 2001.
9. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., and Neckers, L. M. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. USA, 91: 8324-8328, 1994.
10. Stepanova, L., Leng, X., Parker, S. B., and Harper, J. W. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev., 10: 1491-1502, 1996.
11. Dey, B., Lightbody, J. J., and Boschelli, F. CDC37 is required for p60v-src activity in yeast. Mol. Biol. Cell, 7: 1405-1417, 1996.
12. Basso, A. D., Solit, D. B., Chiosis, G., Giri, B., Tsichlis, P., and Rosen, N. Akt forms an intracellular complex with Hsp90 and Cdc37 and is destabilized by inhibitors of Hsp90 functiom. J. Biol. Chem., 9: 9, 2002.
13. Rao, J., Lee, P., Benzeno, S., Cardozo, C., Albertus, J., Robins, D. M., and Caplan, A. J. Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor. J. Biol. Chem., 276: 5814-5820, 2001.
14. Kaelin, W. G., Jr. Functions of the retinoblastoma protein. Bioessays, 21: 950-958, 1999.
15. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
16. Wang, T. C., Cardiff, R. D., Zukerberg, L., Lees, E., Arnold, A., and Schmidt, E. V. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature (Lond.), 369: 669-671, 1994.
17. Sotillo, R., Dubus, P., Martin, J., de la Cueva, E., Ortega, S., Malumbres, M., and Barbacid, M. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J., 20: 6637-6647, 2001.
18. Burgering, B. M., and Bos, J. L. Regulation of Ras-mediated signalling: more than one way to skin a cat. Trends Biochem. Sci., 20: 18-22, 1995.
19. Dhillon, A. S., and Kolch, W. Untying the regulation of the Raf-1 kinase. Arch. Biochem. Biophys., 404: 3-9, 2002.
20. Marais, R., Light, Y., Paterson, H. F., and Marshall, C. J. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J., 14: 3136-3145, 1995.
21. Marshall, C. J. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev., 4: 82-89, 1994.
22. Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R., and Pouyssegur, J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271: 20608-20616, 1996.
23. Zhu, J., Woods, D., McMahon, M., and Bishop, J. M. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev., 12: 2997-3007, 1998.
24. Olsen, C. L., Gardie, B., Yaswen, P., and Stampfer, M. R. Raf-1-induced growth arrest in human mammary epithelial cells is p16 independent and is overcome in immortal cells during conversion. Oncogene, 21: 6328-6339, 2002.
25. Jarrard, D. F., Bova, G. S., and Isaacs, W. B. DNA methylation, molecular genetic, and linkage studies in prostate cancer. Prostate Suppl., 6: 36-44, 1996.
26. Jarrard, D. F., Sarkar, S., Shi, Y., Yeager, T. R., Magrane, G., Kinoshita, H., Nassif, N., Meisner, L., Newton, M. A., Waldman, F. M., and Reznikoff, C. A. p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells. Cancer Res., 59: 2957-2964, 1999.
27. Reznikoff, C. A., Loretz, L. J., Pesciotta, D. M., Oberley, T. D., and Ignjatovic, M. M. Growth kinetics and differentiation in vitro of normal human uroepithelial cells on collagen gel substrates in defined medium. J. Cell. Physiol., 131: 285-301, 1987.
28. Samuels, M. L., Weber, M. J., Bishop, J. M., and McMahon, M. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol. Cell. Biol., 13: 6241-6252, 1993.
29. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA, 92: 9363-9367, 1995.
30. Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell, 77: 841-852, 1994.
31. Severino, J., Allen, R. G., Balin, S., Balin, A., and Cristofalo, V. J. Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp. Cell Res., 257: 162-171, 2000.
32. Quelle, D. E., Ashmun, R. A., Shurtleff, S. A., Kato, J. Y., Bar-Sagi, D., Roussel, M. F., and Sherr, C. J. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev., 7: 1559-1571, 1993.
33. Chen, Y., Martinez, L. A., LaCava, M., Coghlan, L., and Conti, C. J. Increased cell growth and tumorigenicity in human prostate LNCaP cells by overexpression to cyclin D1. Oncogene, 16: 1913-1920, 1998.
34. Berges, R. R., Vukanovic, J., Epstein, J. I., CarMichel, M., Cisek, L., Johnson, D. E., Veltri, R. W., Walsh, P. C., and Isaacs, J. T. Implication of cell kinetic changes during the progression of human prostatic cancer. Clin. Cancer Res., 1: 473-480, 1995.
35. Greenberg, N. M., DeMayo, F., Finegold, M. J., Medina, D., Tilley, W. D., Aspinall, J. O., Cunha, G. R., Donjacour, A. A., Matusik, R. J., and Rosen, J. M. Prostate cancer in a transgenic mouse. Proc. Natl. Acad. Sci. USA, 92: 3439-3443, 1995.
36. Tran, C. P., Lin, C., Yamashiro, J., and Reiter, R. E. Prostate stem cell antigen is a marker of late intermediate prostate epithelial cells. Mol. Cancer Res., 1: 113-121, 2002.
37. Liu, A. Y., Nelson, P. S., van den Engh, G., and Hood, L. Human prostate epithelial cell-type cDNA libraries and prostate expression patterns. Prostate, 50: 92-103, 2002.
38. Verhagen, A. P., Ramaekers, F. C., Aalders, T. W., Schaafsma, H. E., Debruyne, F. M., and Schalken, J. A. Colocalization of basal and luminal cell-type cytokeratins in human prostate cancer. Cancer Res., 52: 6182-6187, 1992.
39. Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Veronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., Andre, B., Arkin, A. P., Astromoff, A., El-Bakkoury, M., Bangham, R., Benito, R., Brachat, S., Campanaro, S., Curtiss, M., Davis, K., Deutschbauer, A., Entian, K. D., Flaherty, P., Foury, F., Garfinkel, D. J., Gerstein, M., Gotte, D., Guldener, U., Hegemann, J. H., Hempel, S., Herman, Z., Jaramillo, D. F., Kelly, D. E., Kelly, S. L., Kotter, P., LaBonte, D., Lamb, D. C., Lan, N., Liang, H., Liao, H., Liu, L., Luo, C., Lussier, M., Mao, R., Menard, P., Ooi, S. L., Revuelta, J. L., Roberts, C. J., Rose, M., Ross-Macdonald, P., Scherens, B., Schimmack, G., Shafer, B., Shoemaker, D. D., Sookhai-Mahadeo, S., Storms, R. K., Strathem, J. N., Valle, G., Voet, M., Volckaert, G., Wang, C. Y., Ward, T. R., Wilhelmy, J., Winzeler, E. A., Yang, Y., Yen, G., Youngman, E., Yu, K., Bussey, H., Boeke, J. D., Snyder, M., Philippsen, P., Davis, R. W., and Johnston, M. Functional profiling of the Saccharomyces cerevisiae genome. Nature (Lond.), 418: 387-391, 2002.
40. Ravi, R. K., McMahon, M., Yangang, Z., Williams, J. R., Dillehay, L. E., Nelkin, B. D., and Mabry, M. Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells. J. Cell. Biochem., 72: 458-469, 1999.
41. Blagosklonny, M. V. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia (Baltimore), 16: 455-462, 2002.
42. Neckers, L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med., 8: S55-S61, 2002.