Apoptosis and lung cancer: A review

Journal of Cellular Biochemistry

Volumn 88, Issue 5, 2003, Pages 885-898

  Shivapurkar, Narayan ^a,b   Reddy, Jyotsna ^a   Chaudhary, Preet M ^a   Gazdar, Adi F ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Chemosensitivity; Lung cancer; P53

Indexed keywords

ANTINEOPLASTIC AGENT; DEATH ASSOCIATED PROTEIN KINASE; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER GENETICS; CANCER MORTALITY; CANCER RESISTANCE; CARCINOGENESIS; DRUG SENSITIVITY; GENE; HUMAN; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MITOCHONDRION; NONHUMAN; PRECANCER; PRIORITY JOURNAL; REVIEW; TMS1 GENE; TREATMENT OUTCOME;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CYTOSKELETAL PROTEINS; DRUG RESISTANCE, NEOPLASM; GENES, BCL-2; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; MUTATION; PRECANCEROUS CONDITIONS; PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037376628     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10440     Document Type: Review

References (90)

1. Adrain C, Martin SJ. 2001. The mitochondrial apoptosome: A killer unleashed by the cytochrome seas. Trends Biochem Sci 26:390-397.
2. Altieri DC. 2001. The molecular basis and potential role of survivin in cancer diagnosis and therapy. Trends Mol Med 7:542-547.
3. Amati B, Alevizopoulos K, Vlach J. 1998. Myc and the cell cycle. Front Biosci 3:D250-D268.
4. Aravind L, Dixit VM, Koonin EV. 2001. Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons. Science 291: 1279-1284.
5. Ashkenazi A, Dixit VM. 1999. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11:255-260.
6. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. 2001. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 10:687-692.
7. Belinsky SA, Palmisano WA, Gilliland FD, Crooks LA, Divine KK, Winters SA, Grimes MJ, Harms HJ, Tellez CS, Smith TM, Moots PP, Lechner JF, Stidley CA, Crowell RE. 2002. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res 62:2370-2377.
8. Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P, Blenis J, Tschopp J. 2000. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2:241-243.
9. Brambilla E, Negoescu A, Gazzeri S, Lantuejoul S, Moro D, Brambilla C, Coll JL. 1996. Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol 149:1941-1952.
10. Chen Y, Sato M, Fujimura S, Endo C, Sakurada A, Aikawa H, Takahashi H, Tanita T, Kondo T, Saito Y, Sagawa M. 1999. Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer. Anticancer Res 19:1351-1356.
11. Chu E, DeVita V. 2000. Principles of cancer management: Chemotherapy. In: DeVita V, Hellman S, Rosenberg S, editors. Cancer: Principles & practice of oncology. Philadelphia: Lippincott-Raven. pp 289-306.
12. Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM. 2000. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res 60:6236-6242.
13. Cory S, Adams JM. 2002. The bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647-656.
14. Cretney E, Takeda K, Yagita H, Glaccum M, Peschon JJ, Smyth MJ. 2002. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol 168:1356-1361.
15. Dong SM, Kim HS, Rha SH, Sidransky D. 2001. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res 7:1982-1986.
16. Du C, Fang M, Li Y, Li L, Wang X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33-42.
17. Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Janicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S. 2000. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 19:4563-4573.
18. Esteller M, Sanchez-Cespedes M, Rosell R, Sidransky D, Baylin SB, Herman JG. 1999. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59:67-70.
19. Esteller M, Corn PG, Baylin SB, Herman JG. 2001. A gene hypermethylation profile of human cancer. Cancer Res 61:3225-3229.
20. Evan G, Littlewood T. 1998. A matter of life and cell death. Science 281:1317-1322.
21. Evan GI, Vousden KH. 2001. Proliferation, cell cycle and apoptosis in cancer. Nature 411:342-348.
22. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128.
23. Feinstein E, Kimchi A, Wallach D, Boldin M, Varfolomeev E. 1995. The death domain: A module shared by proteins with diverse cellular functions [letter]. Trends Biochem Sci 20:342-344.
24. Ferreira CG, Span SW, Peters GJ, Kruyt FA, Giaccone G. 2000a. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res 60:7133-7141.
25. Ferreira CG, Span SW, Peters GJ, Kruyt FA, Giaccone G. 2000b. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res 60:7133-7141.
26. Ferreira CG, van der Valk P, Span SW, Jonker JM, Postmus PE, Kruyt FA, Giaccone G. 2001a. Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. Ann Oncol 12:799-805.
27. Ferreira CG, van der Valk P, Span SW, Ludwig I, Smit EF, Kruyt FA, Pinedo HM, van Tinteren H, Giaccone G. 2001b. Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients. Clin Cancer Res 7:2468-2474.
28. Ferron PE, Bagni I, Guidoboni M, Beccati MD, Nenci I. 1997. Combined and sequential expression of p53, Rb, Ras and Bcl-2 in bronchial preneoplastic lesions. Tumori 83:587-593.
29. Fine A, Janssen-Heininger Y, Soultanakis RP, Swisher SG, Uhal BD. 2000. Apoptosis in lung pathophysiology. Am J Physiol Lung Cell Mol Physiol 279:L423-L427.
30. Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF, Minna JD. 2000. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 60:4894-4906.
31. Goncalves A, Braguer D, Carles G, Andre N, Prevot C, Briand C. 2000. Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). Biochem Pharmacol 60:1579-1584.
32. Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100:57-70.
33. Hanaoka T, Nakayama J, Mukai J, Irie S, Yamanda T, Sato TA. 2001. Association of smoking with apoptosis-regulated proteins (Bcl-2, bax and p53) in resected non-small-cell lung cancers. Int J Cancer 91:267-269.
34. Horvitz HR. 1999. Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cancer Res 59:1701s-1706s.
35. Hussain SP, Hollstein MH, Harris CC. 2000. p53 tumor suppressor gene: At the crossroads of molecular carcino-genesis, molecular epidemiology, and human risk assess-ment. Ann N Y Acad Sci 919:79-85.
36. Hwang JH, Lim SC, Kim YC, Park KO, Ahn SJ, Chung WK. 2001. Apoptosis and bcl-2 expression as predictors of survival in radiation-treated non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 50:13-18.
37. Inbal B, Cohen O, Polak-Charcon S, Kopolovic J, Vadai E, Eisenbach L, Kimchi A. 1997. DAP kinase links the control of apoptosis to metastasis. Nature 390:180-184.
38. Ishida H, Irie K, Itoh T, Furukawa T, Tokunaga O. 1997. The prognostic significance of p53 and bcl-2 expression in lung adenocarcinoma and its correlation with Ki-67 growth fraction. Cancer 80:1034-1045.
39. Jones PA. 2001. Cancer. Death and methylation. Nature 409:141, 143-144.
40. Joseph B, Ekedahl J, Sirzen F, Lewensohn R, Zhivotovsky B. 1999. Differences in expression of pro-caspases in small cell and non-small cell lung carcinoma. Biochem Biophys Res Commun 262:381-387.
41. Joseph B, Lewensohn R, Zhivotovsky B. 2000. Role of apoptosis in the response of lung carcinomas to anti-cancer treatment. Ann N Y Acad Sci 926:204-216.
42. Kalomenidis I, Orphanidou D, Papamichalis G, Vassilakopoulos T, Skorilas A, Rasidakis A, Papastamatiou H, Jordanoglou J, Roussos C. 2001. Combined expression of p53, Bcl-2, and p21WAF-1 proteins in lung cancer and premalignant lesions: Association with clinical characteristics. Lung 179:265-278.
43. Kim DH, Nelson HH, Wiencke JK, Christiani DC, Wain JC, Mark EJ, Kelsey KT. 2001. Promoter methylation of DAP-kinase: Association with advanced stage in non-small cell lung cancer. Oncogene 20:1765-1770.
44. Kimchi A. 1998. DAP genes: Novel apoptotic genes isolated by a functional approach to gene cloning. Biochim Biophys Acta 1377:F13-F33.
45. Kischkel FC, Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P, Gazdar A, Blenis J, Arnott D, Ashkenazi A. 2001. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem 276:46639-46646.
46. Kitamura H, Kameda Y, Ito T, Hayashi H. 1999. Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma [see comments]. Am J Clin Pathol 111:610-622.
47. Knudson AG. 1985. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 45:1437-1443.
48. Kogel D, Plottner O, Landsberg G, Christian S, Scheidtmann KH. 1998. Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones. Oncogene 17:2645-2654.
49. Kogel D, Prehn JH, Scheidtmann KH. 2001. The DAP kinase family of pro-apoptotic proteins: Novel players in the apoptotic game. Bioessays 23:352-358.
50. LaCasse EC, Baird S, Korneluk RG, MacKenzie AE. 1998. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 17:3247-3259.
51. Li H, Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
52. Li LY, Luo X, Wang X. 2001. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412:95-99.
53. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. 1998. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490.
54. Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N, Hidaka E, Katsuyama T, Higuchi T, Sagara J. 1999. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 274:33835-33838.
55. Matta H, Eby MT, Chaudhary PM, Gazdar AF. 2002. Role of MRIT/cFLIP in protection against chemotherapyinduced apoptosis. Cancer Biol Ther (in press).
56. Melino G, De Laurenzi V, Vousden KH. 2002. p73: Friend or foe in tumorigenesis. Nat Rev Cancer 2:605-615.
57. Milner AE, Palmer DH, Hodgkin EA, Eliopoulos AG, Knox PG, Poole CJ, Kerr DJ, Young LS. 2002. Induction of apoptosis by chemotherapeutic drugs: The role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells. Cell Death Differ 9:287-300.
58. Monzo M, Rosell R, Felip E, Astudillo J, Sanchez JJ, Maestre J, Martin C, Font A, Barnadas A, Abad A. 1999. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. J Clin Oncol 17:2100-2104.
59. Parkin DM, Bray FI, Devesa SS. 2001. Cancer burden in the year 2000. The global picture. Eur J Cancer 37 Suppl 8:4-66.
60. Prendergast GC. 1999. Mechanisms of apoptosis by c-Myc. Oncogene 18:2967-2987.
61. Raveh T, Kimchi A. 2001. DAP kinase - A proapoptotic gene that functions as a tumor suppressor. Exp Cell Res 264:185-192.
62. Sartorius UA, Krammer PH. 2002. Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer 97:584-592.
63. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME. 1998. Two CD95 (APO-1/Fas) signaling pathways. Embo J 17:1675-1687.
64. Seki K, Yoshikawa H, Shiiki K, Hamada Y, Akamatsu N, Tasaka K. 2000. Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother Pharmacol 45:199-206.
65. Shivapurkar N, Reddy JL, Matta H, Sathyanarayana UG, Huang CX, Toyooka S, Minna JD, Chaudhary PM, Gazdar AF. 2002a. Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Oncogene 21:8510-8514.
66. Shivapurkar N, Toyooka S, Eby MT, Huang CX, Sathyanarayana UG, Cunningham TH, Reddy JL, Brambilla E, Takahashi T, Minna JD, Chaudhary PM, Gazdar AF. 2002b. Differential inactivation of caspase-8 in lung cancers. Cancer Biol Ther 1:54-58.
67. Soengas MS, Alarcon RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW, Lowe SW. 1999. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284:156-159.
68. Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X, McCombie R, Herman JG, Gerald WL, Lazebnik YA, Cordon-Cardo C, Lowe SW. 2001. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409:207-211.
69. Soini Y, Paakko P, Lehto VP. 1998. Histopathological evaluation of apoptosis in cancer. Am J Pathol 153:1041-1053.
70. Soussi T. 1996. The p53 tumour suppressor gene: A model for molecular epidemiology of human cancer. Mol Med Today 2:32-37.
71. Stennicke HR, Salvesen GS. 2000. Caspases-controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta 1477:299-306.
72. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446.
73. Tang X, Khuri FR, Lee JJ, Kemp BL, Liu D, Hong WK, Mao L. 2000. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J Natl Cancer Inst 92:1511-1516.
74. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ. 2000a. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 6:529-535.
75. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ. 2000b. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN [see comments]. Nat Med 6:529-535.
76. Teitz T, Wei T, Liu D, Valentine V, Valentine M, Grenet J, Lahti JM, Kidd VJ. 2002. Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. Oncogene 21:1848-1858.
77. Tormanen U, Nuorva K, Soini Y, Paakko P. 1999. Apoptotic activity is increased in parallel with the metaplasiadysplasia-carcinoma sequence of the bronchial epithelium. Br J Cancer 79:996-1002.
78. Travis WD, Travis LB, Devesa SS. 1995. Lung cancer. Cancer 75:191-202.
79. Vahakangas KH, Bennett WP, Castren K, Welsh JA, Khan MA, Blomeke B, Alavanja MC, Harris CC. 2001. p53 and K-ras mutations in lung cancers from former and neversmoking women. Cancer Res 61:4350-4356.
80. Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D. 1998. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9:267-276.
81. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL. 2000. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102:43-53.
82. Vousden KH, Lu X. 2002. Live or let die: The cell's response to p53. Nat Rev Cancer 2:594-604.
83. Wang X. 2001. The expanding role of mitochondria in apoptosis. Genes Dev 15:2922-2933.
84. Webb SJ, Harrison DJ, Wyllie AH. 1997. Apoptosis: An overview of the process and its relevance in disease. Adv Pharmacol 41:1-34.
85. Wistuba II, Behrens C, Milchgrub S, Bryant D, Hung J, Minna JD, Gazdar AF. 1999. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene 18: 643-650.
86. Wistuba II, Barry J, Behrens C, Maitra A, Shivapurkar N, Milchgrub S, Mackay B, Minna JD, Gazdar AF. 2000. Molecular changes in the bronchial epithelium of patients with small cell lung cancer. Clin Cancer Res 6:2604-2610.
87. Wyllie AH. 1997. Apoptosis: An overview. Br Med Bull 53:451-465.
88. Zhang H, Yousem SA, Franklin WA, Elder E, Landreneau R, Ferson P, Keenan R, Whiteside T, Levitt ML. 1998. Differentiation and programmed cell death-related intermediate biomarkers for the development of non-small cell lung cancer: A pilot study. Hum Pathol 29:965-971.
89. Zochbauer-Muller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD. 2001. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61:249-255.
90. Zochbauer-Muller S, Gazdar AF, Minna JD. 2002. Molecular pathogenesis of lung cancer. Annu Rev Physiol 64:681-708.