Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

Journal of Medicinal Chemistry

Volumn 42, Issue 2, 1999, Pages 260-266

  Roe, S Mark ^a   Prodromou, Chrisostomos ^a   O'Brien, Ronan ^a   Ladbury, John E ^a   Piper, Peter W ^a   Pearl, Laurence H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GELDANAMYCIN; HEAT SHOCK PROTEIN 90; RADICICOL;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG PROTEIN BINDING; MOLECULAR MIMICRY; NONHUMAN; PROTEIN FOLDING; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; HSP90 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; LACTONES; MACROLIDES; MODELS, MOLECULAR; MOLECULAR MIMICRY; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032959590     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980403y     Document Type: Article

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