Triggering caspase-independent cell death to combat cancer

Trends in Molecular Medicine

Volumn 8, Issue 5, 2002, Pages 212-220

  Mathiasen, Ida S ^a   Jäättelä, Marja ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CASPASE; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; GRANZYME A; GRANZYME B; SERINE PROTEINASE;

CANCER; CANCER CELL; CANCER INHIBITION; CELL DEATH; ENZYME ACTIVATION; HUMAN; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL;

APOPTOSIS; CASPASES; CELL DEATH; ENDOPEPTIDASES; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 0036256178     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02328-6     Document Type: Review

References (71)

1. Programmed cell death: Alive and well in the new millennium
2. Apoptosis signaling
3. Organelle-specific initiation of cell death pathways
4. Caspase-independent programmed cell death with necrotic morphology
5. Four deaths and a funeral: From caspases to alternative mechanisms
6. A serine protease, htra2, is released from the mitochondria and interacts with xiap, inducing cell death
7. Escaping cell death: Survival proteins in cancer
8. Proliferation, cell cycle and apoptosis in cancer
9. Apoptosis-regulating proteins as targets for drug discovery
10. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
11. HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance
12. Strategies for immunotherapy of cancer
13. Inhibition of death receptor signals by cellular FLIP
14. Mutations in the Fas antigen in patients with multiple myeloma
15. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
16. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
17. Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2
18. CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells
19. Cathepsins as effector proteases in hepatocyte apoptosis
20. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
21. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53
22. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2
23. The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program
24. An alternative, nonapoptotic form of programmed cell death
25. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines
26. Triggering of apoptosis by cathepsins
27. Caenorhabditis elegans p53: Role in apoptosis, meiosis, and stress resistance
28. Noncaspase proteases in apoptosis
29. Calpain and caspase: Can you tell the difference?
30. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: Protective role of Bcl-2
31. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis
32. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
33. The role of calpain in caspase activation during etoposide induced apoptosis in T cells
34. Calpain activation is upstream of caspases in radiation-induced apoptosis
35. Lysosomal cysteine proteases: Facts and opportunities
36. Cathepsin D targeted by acid sphingomyelinase-derived ceramide
37. Cathepsin B contributes to TNF-α-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
38. Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice
39. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
40. Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy
41. Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells
42. Sphingosine-induced apoptosis is dependent on lysosomal proteases
43. Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells
44. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
45. Granule-mediated killing: Pathways for granzyme B-initiated apoptosis
46. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
47. Activation of CPP32-like proteases is not sufficient to trigger apoptosis: Inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity
48. Chemotherapeutic drug activation of the AP24 protease in apoptosis: Requirement for caspase 3-like-proteases
49. L-DNase II, a molecule that links proteases and endonucleases in apoptosis, derives from the ubiquitous serpin leukocyte elastase inhibitor
50. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
51. Lysosomal protease pathways to apoptosis, cleavage of Bid, not pro-caspases, is the most likely route
52. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members Bid and Bax
53. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
54. Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: Degradation of apoptotic protease activating factor-1 (APAF-1)
55. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
56. The 'harmless' release of cytochrome c
57. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
58. Endonuclease G is an apoptotic DNase when released from mitochondria
59. Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
60. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death
61. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
62. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
63. Resistance to the cytotoxic effects of tumor necrosis factor α can be overcome by inhibition of a FADD/caspase-dependent signaling pathway
64. A kinase-independent function of ask1 in caspase-independent cell death
65. Heat shock protein 70 is required for the survival of cancer cells
66. Cysteine proteinase inhibitor cystatin A in breast cancer
67. PML induces a novel caspase-independent death process
68. Signaling pathways in apoptosis as potential targets for cancer therapy
69. Cutting edge: Differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities
70. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
71. CD99 signals caspase-independent T cell death