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Volumn 15, Issue 5, 2003, Pages 528-532

Cytotoxic granule-mediated apoptosis: Unraveling the complex mechanism

Author keywords

[No Author keywords available]

Indexed keywords

CATION; CHAPERONE; CLATHRIN; DYNAMIN; GRANZYME A; GRANZYME B; GRANZYME C; GRANZYME D; GRANZYME E; GRANZYME F; GRANZYME G; GRANZYME H; GRANZYME K; GRANZYME M; HERMES ANTIGEN; PERFORIN; PROTEIN; PROTEOCHONDROITIN SULFATE; PROTEOGLYCAN; SERGLYCIN; TOXIN; UNCLASSIFIED DRUG;

EID: 0141518343     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(03)00111-0     Document Type: Review
Times cited : (46)

References (41)
  • 1
    • 0036217977 scopus 로고    scopus 로고
    • Lymphocyte-mediated cytotoxicity
    • Russell J.H., Ley T.J. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol. 20:2002;323-370.
    • (2002) Annu Rev Immunol , vol.20 , pp. 323-370
    • Russell, J.H.1    Ley, T.J.2
  • 2
    • 0036595397 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes: All roads lead to death
    • Barry M., Bleackley R.C. Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol. 2:2002;401-409.
    • (2002) Nat Rev Immunol , vol.2 , pp. 401-409
    • Barry, M.1    Bleackley, R.C.2
  • 3
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani J.A., Smyth M.J. Functional significance of the perforin/ granzyme cell death pathway. Nat Rev Immunol. 2:2002;735-747.
    • (2002) Nat Rev Immunol , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 4
    • 0036195424 scopus 로고    scopus 로고
    • Cytotoxic-cell granule-mediated apoptosis: Perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
    • Demonstration that it is a complex of GrB with SG that induces apoptosis physiologically.
    • Metkar S.S., Wang B., Aguilar-Santelises M., Raja S.M., Uhlin-Hansen L., Podack E., Trapani J.A., Froelich C.J. Cytotoxic-cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 16:2002;417-428 Demonstration that it is a complex of GrB with SG that induces apoptosis physiologically.
    • (2002) Immunity , vol.16 , pp. 417-428
    • Metkar, S.S.1    Wang, B.2    Aguilar-Santelises, M.3    Raja, S.M.4    Uhlin-Hansen, L.5    Podack, E.6    Trapani, J.A.7    Froelich, C.J.8
  • 5
    • 0033136316 scopus 로고    scopus 로고
    • Apoptosis induced by granzyme B-glycosaminoglycan complexes: Implications for granule-mediated apoptosis in vivo
    • Galvin J.P., Spaeny-Dekking L.H., Wang B., Seth P., Hack C.E., Froelich C.J. Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 162:1999;5345-5350.
    • (1999) J Immunol , vol.162 , pp. 5345-5350
    • Galvin, J.P.1    Spaeny-Dekking, L.H.2    Wang, B.3    Seth, P.4    Hack, C.E.5    Froelich, C.J.6
  • 6
    • 0014932541 scopus 로고
    • In vitro cytotoxic activity of thymus cells sensitized to alloantigens
    • Cerottini J.C., Nordin A.A., Brunner K.T. In vitro cytotoxic activity of thymus cells sensitized to alloantigens. Nature. 227:1970;72-73.
    • (1970) Nature , vol.227 , pp. 72-73
    • Cerottini, J.C.1    Nordin, A.A.2    Brunner, K.T.3
  • 7
    • 0022497854 scopus 로고
    • Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity
    • Young J.D., Hengartner H., Podack E.R., Cohn Z.A. Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell. 44:1986;849-859.
    • (1986) Cell , vol.44 , pp. 849-859
    • Young, J.D.1    Hengartner, H.2    Podack, E.R.3    Cohn, Z.A.4
  • 8
    • 0021859627 scopus 로고
    • A novel serine esterase expressed by cytotoxic T lymphocytes
    • Pasternack M.S., Eisen H.N. A novel serine esterase expressed by cytotoxic T lymphocytes. Nature. 314:1985;743-745.
    • (1985) Nature , vol.314 , pp. 743-745
    • Pasternack, M.S.1    Eisen, H.N.2
  • 9
    • 0025973806 scopus 로고
    • A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene
    • Shiver J.W., Henkart P.A. A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/ perforin gene. Cell. 64:1991;1175-1181.
    • (1991) Cell , vol.64 , pp. 1175-1181
    • Shiver, J.W.1    Henkart, P.A.2
  • 10
    • 0026753388 scopus 로고
    • Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A
    • Shiver J.W., Su L., Henkart P.A. Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A. Cell. 71:1992;315-322.
    • (1992) Cell , vol.71 , pp. 315-322
    • Shiver, J.W.1    Su, L.2    Henkart, P.A.3
  • 12
    • 0022297121 scopus 로고
    • Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis
    • MacDermott R.P., Schmidt R.E., Caulfield J.P., Hein A., Bartley G.T., Ritz J., Schlossman S.F., Austen K.F., Stevens R.L. Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. J Exp Med. 162:1985;1771-1787.
    • (1985) J Exp Med , vol.162 , pp. 1771-1787
    • MacDermott, R.P.1    Schmidt, R.E.2    Caulfield, J.P.3    Hein, A.4    Bartley, G.T.5    Ritz, J.6    Schlossman, S.F.7    Austen, K.F.8    Stevens, R.L.9
  • 13
    • 0025672874 scopus 로고
    • Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T cells is dependent on pH
    • Masson D., Peters P.J., Geuze H.J., Borst J., Tschopp J. Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T cells is dependent on pH. Biochemistry. 29:1990;11229-11235.
    • (1990) Biochemistry , vol.29 , pp. 11229-11235
    • Masson, D.1    Peters, P.J.2    Geuze, H.J.3    Borst, J.4    Tschopp, J.5
  • 14
    • 0023025461 scopus 로고
    • Complexes of heparin proteoglycans, chondroitin sulfate E proteoglycans, and [3H]diisopropyl fluorophosphate-binding proteins are exocytosed from activated mouse bone-marrow-derived mast cells
    • Serafin W.E., Katz H.R., Austen K.F., Stevens R.L. Complexes of heparin proteoglycans, chondroitin sulfate E proteoglycans, and [3H]diisopropyl fluorophosphate-binding proteins are exocytosed from activated mouse bone-marrow-derived mast cells. J Biol Chem. 261:1986;15017-15021.
    • (1986) J Biol Chem , vol.261 , pp. 15017-15021
    • Serafin, W.E.1    Katz, H.R.2    Austen, K.F.3    Stevens, R.L.4
  • 15
    • 0037147261 scopus 로고    scopus 로고
    • Cytotoxic-cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin
    • The first report revealing the biophysical basis for the tight association of GrB with SG, strengthening the idea that the protease-proteoglycan complex is the physiological form of exocytosed GrB.
    • Raja S.M., Wang B., Dantuluri M., Desai U.R., Demeler B., Spiegel K., Metkar S.S., Froelich C.J. Cytotoxic-cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem. 277:2002;49523-49530 The first report revealing the biophysical basis for the tight association of GrB with SG, strengthening the idea that the protease-proteoglycan complex is the physiological form of exocytosed GrB.
    • (2002) J Biol Chem , vol.277 , pp. 49523-49530
    • Raja, S.M.1    Wang, B.2    Dantuluri, M.3    Desai, U.R.4    Demeler, B.5    Spiegel, K.6    Metkar, S.S.7    Froelich, C.J.8
  • 16
    • 0035900714 scopus 로고    scopus 로고
    • Granzyme A activates an endoplasmic-reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
    • Beresford P.J., Zhang D., Oh D.Y., Fan Z., Greer E.L., Russo M.L., Jaju M., Lieberman J. Granzyme A activates an endoplasmic-reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem. 276:2001;43285-43293.
    • (2001) J Biol Chem , vol.276 , pp. 43285-43293
    • Beresford, P.J.1    Zhang, D.2    Oh, D.Y.3    Fan, Z.4    Greer, E.L.5    Russo, M.L.6    Jaju, M.7    Lieberman, J.8
  • 17
    • 0036199666 scopus 로고    scopus 로고
    • HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
    • Fan Z., Beresford P.J., Zhang D., Lieberman J. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol. 22:2002;2810-2820.
    • (2002) Mol Cell Biol , vol.22 , pp. 2810-2820
    • Fan, Z.1    Beresford, P.J.2    Zhang, D.3    Lieberman, J.4
  • 19
    • 0037423932 scopus 로고    scopus 로고
    • Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor
    • Fan Z., Beresford P.J., Oh D.Y., Zhang D., Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell. 112:2003;659-672.
    • (2003) Cell , vol.112 , pp. 659-672
    • Fan, Z.1    Beresford, P.J.2    Oh, D.Y.3    Zhang, D.4    Lieberman, J.5
  • 20
    • 0037318699 scopus 로고    scopus 로고
    • Granzyme A: The road less traveled
    • Pinkoski M.J., Green D.R. Granzyme A: the road less traveled. Nat Immunol. 4:2003;106-108.
    • (2003) Nat Immunol , vol.4 , pp. 106-108
    • Pinkoski, M.J.1    Green, D.R.2
  • 22
    • 0037451224 scopus 로고    scopus 로고
    • Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
    • Using targets deficient in procaspase-3, this paper, together with [21], firmly establishes that granzyme B initiates apoptosis by triggering the action of the apical caspases. The paper emphasizes that the processing of intracellular substrates depends on the accessibility as well as the reactivity of the substrate.
    • Metkar S.S., Wang B., Ebbs M.L., Kim J.H., Lee Y.J., Raja S.M., Froelich C.J. Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol. 160:2003;875-885 Using targets deficient in procaspase-3, this paper, together with [21], firmly establishes that granzyme B initiates apoptosis by triggering the action of the apical caspases. The paper emphasizes that the processing of intracellular substrates depends on the accessibility as well as the reactivity of the substrate.
    • (2003) J Cell Biol , vol.160 , pp. 875-885
    • Metkar, S.S.1    Wang, B.2    Ebbs, M.L.3    Kim, J.H.4    Lee, Y.J.5    Raja, S.M.6    Froelich, C.J.7
  • 23
    • 0027318806 scopus 로고
    • Killing by cytotoxic T cells and natural killer cells: Multiple granule serine proteases as initiators of DNA fragmentation
    • Trapani J.A., Smyth M.J. Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation. Immunol Cell Biol. 71:1993;201-208.
    • (1993) Immunol Cell Biol , vol.71 , pp. 201-208
    • Trapani, J.A.1    Smyth, M.J.2
  • 24
    • 0028952301 scopus 로고
    • Granzymes: Exogenous proteinases that induce target cell apoptosis
    • Smyth M.J., Trapani J.A. Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today. 16:1995;202-206.
    • (1995) Immunol Today , vol.16 , pp. 202-206
    • Smyth, M.J.1    Trapani, J.A.2
  • 25
    • 0034694091 scopus 로고    scopus 로고
    • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme-B-mediated caspase activation
    • Sutton V.R., Davis J.E., Cancilla M., Johnstone R.W., Ruefli A.A., Sedelies K., Browne K.A., Trapani J.A. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme-B-mediated caspase activation. J Exp Med. 192:2000;1403-1414.
    • (2000) J Exp Med , vol.192 , pp. 1403-1414
    • Sutton, V.R.1    Davis, J.E.2    Cancilla, M.3    Johnstone, R.W.4    Ruefli, A.A.5    Sedelies, K.6    Browne, K.A.7    Trapani, J.A.8
  • 27
    • 0036312429 scopus 로고    scopus 로고
    • The differential contribution of granzyme A and granzyme B in cytotoxic-T-lymphocyte-mediated apoptosis is determined by the quality of target cells
    • Pardo J., Balkow S., Anel A., Simon M.M. The differential contribution of granzyme A and granzyme B in cytotoxic-T-lymphocyte-mediated apoptosis is determined by the quality of target cells. Eur J Immunol. 32:2002;1980-1985.
    • (2002) Eur J Immunol , vol.32 , pp. 1980-1985
    • Pardo, J.1    Balkow, S.2    Anel, A.3    Simon, M.M.4
  • 28
    • 0035655587 scopus 로고    scopus 로고
    • The immunological synapse of CTL contains a secretory domain and membrane bridges
    • Stinchcombe J.C., Bossi G., Booth S., Griffiths G.M. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity. 15:2001;751-761.
    • (2001) Immunity , vol.15 , pp. 751-761
    • Stinchcombe, J.C.1    Bossi, G.2    Booth, S.3    Griffiths, G.M.4
  • 30
    • 10544252275 scopus 로고    scopus 로고
    • New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
    • Froelich C.J., Orth K., Turbov J., Seth P., Gottlieb R., Babior B., Shah G.M., Bleackley R.C., Dixit V.M., Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 271:1996;29073-29079.
    • (1996) J Biol Chem , vol.271 , pp. 29073-29079
    • Froelich, C.J.1    Orth, K.2    Turbov, J.3    Seth, P.4    Gottlieb, R.5    Babior, B.6    Shah, G.M.7    Bleackley, R.C.8    Dixit, V.M.9    Hanna, W.10
  • 31
    • 0042377711 scopus 로고    scopus 로고
    • The human cytotoxic-T-cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme-B-containing endosomes
    • Edwards K.M., Kam C.M., Powers J.C., Trapani J.A. The human cytotoxic-T-cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme-B-containing endosomes. J Biol Chem. 274:1999;30468-30473.
    • (1999) J Biol Chem , vol.274 , pp. 30468-30473
    • Edwards, K.M.1    Kam, C.M.2    Powers, J.C.3    Trapani, J.A.4
  • 32
    • 0034721646 scopus 로고    scopus 로고
    • Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic-T-cell-induced apoptosis
    • Motyka B., Korbutt G., Pinkoski M.J., Heibein J.A., Caputo A., Hobman M., Barry M., Shostak I., Sawchuk T., Holmes C.F.et al. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic-T-cell-induced apoptosis. Cell. 103:2000;491-500.
    • (2000) Cell , vol.103 , pp. 491-500
    • Motyka, B.1    Korbutt, G.2    Pinkoski, M.J.3    Heibein, J.A.4    Caputo, A.5    Hobman, M.6    Barry, M.7    Shostak, I.8    Sawchuk, T.9    Holmes, C.F.10
  • 34
    • 0030892138 scopus 로고    scopus 로고
    • Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization
    • Shi L., Mai S., Israels S., Browne K., Trapani J.A., Greenberg A.H. Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization. J Exp Med. 185:1997;855-866.
    • (1997) J Exp Med , vol.185 , pp. 855-866
    • Shi, L.1    Mai, S.2    Israels, S.3    Browne, K.4    Trapani, J.A.5    Greenberg, A.H.6
  • 36
    • 0033499729 scopus 로고    scopus 로고
    • Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin
    • Browne K.A., Blink E., Sutton V.R., Froelich C.J., Jans D.A., Trapani J.A. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol. 19:1999;8604-8615.
    • (1999) Mol Cell Biol , vol.19 , pp. 8604-8615
    • Browne, K.A.1    Blink, E.2    Sutton, V.R.3    Froelich, C.J.4    Jans, D.A.5    Trapani, J.A.6
  • 37
    • 0027452741 scopus 로고
    • Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor
    • Griffiths G.M., Isaaz S. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol. 120:1993;885-896.
    • (1993) J Cell Biol , vol.120 , pp. 885-896
    • Griffiths, G.M.1    Isaaz, S.2
  • 40
    • 0033673428 scopus 로고    scopus 로고
    • DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
    • Thomas D.A., Du C., Xu M., Wang X., Ley T.J. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 12:2000;621-632.
    • (2000) Immunity , vol.12 , pp. 621-632
    • Thomas, D.A.1    Du, C.2    Xu, M.3    Wang, X.4    Ley, T.J.5
  • 41
    • 0028965095 scopus 로고
    • A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation
    • Toyama-Sorimachi N., Sorimachi H., Tobita Y., Kitamura F., Yagita H., Suzuki K., Miyasaka M. A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J Biol Chem. 270:1995;7437-7444.
    • (1995) J Biol Chem , vol.270 , pp. 7437-7444
    • Toyama-Sorimachi, N.1    Sorimachi, H.2    Tobita, Y.3    Kitamura, F.4    Yagita, H.5    Suzuki, K.6    Miyasaka, M.7


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