Multilateral in vivo and in vitro protective effects of the novel heat shock protein coinducer, bimoclomol: Results of preclinical studies

Cardiovascular Drug Reviews

Volumn 19, Issue 2, 2001, Pages 133-151

  Nanasi P P ^a,c   Jednakovits A ^b  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b BIOREX Research and Development   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Angiopathy; Cardiac contraction; Cytoprotection; Diabetes; Heat shock proteins; Ischemic injury; Vasodilation

Indexed keywords

ACETYLCHOLINE; BIMOCLOMOL; BRLP 42; CALCIUM ION; GAMMA LINOLENIC ACID; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HYDROXYLAMINE; PROTECTIVE AGENT; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; BLOOD BRAIN BARRIER; CALCIUM CELL LEVEL; CELL PROTECTION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DOG; DRUG METABOLISM; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; NONHUMAN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; REVIEW; VASCULAR DISEASE; VASODILATATION; WOUND HEALING;

EID: 0034894697     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2001.tb00060.x     Document Type: Review

References (49)

1. Role of oxidative stress in the development of complications in diabetes
2. Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats
3. Bimoclomol improves early electrophysiological signs of retinopathy in diabetic rats
4. Diabetic retinopathy viewed as a neurosensory disorder
5. Nerve blood flow in early experimental diabetes in rats: Relation to conduction deficits
6. Presence and further development of retinal dysfunction after 3-year follow up in IDDM patients without angiographically documented vasculopathy
7. Contrasting effects of treatment with essential fatty acids on peripheral nerve function and capillarization in streptozotocin-induced diabetic rats
8. Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats
9. Heat-shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology
10. Chaperone-mediated protein folding
11. Protein folding in the cell
12. Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F
13. Molecular chaperones in cellular protein folding
14. Differential cytoprotection against heat or hypoxia following expression of specific stress protein genes in myogenic cells
15. Gamma-linolenic acid
16. Heat shock protein induction in rat hearts: A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection
17. Overexpression of heat shock protein 72 in transgenic mouse decreases infarct size in vivo
18. Diabetic nephropathy
19. In vivo and in vitro cardiovascular effects of bimoclomol
20. Effect of subchronic bimoclomol treatment on vascular responsiveness and heat shock protein production in spontaneously hypertensive rats
21. The role of heat shock proteins in the heart
22. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia
23. Effect of chronic dihydropyridine (isradipine) on the large arterial walls of spontaneously hypertensive rats
24. Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy
25. Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats
26. The progression of microangiopathy with neuropathic severity
27. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury
28. Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension
29. Heat shock proteins and molecular shaperones: Implications for adaptive responses in the skin
30. Heat shock proteins and protection against myocardial ischemia
31. Visual evoked potentials in NIDDM: A longitudinal study
32. Cells in stress: Transcriptional activation of heat shock genes
33. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
34. Biphasic effect of bimoclomol on calcium handling in mammalian ventricular myocardium
35. Differential expression of heat shock protein 70 in well healing and chronic human wound tissue
36. Heat shock-induced myocardial protection against ischemic injury: A role for HSP70?
37. Transgenic mice expressing the human HSP 70 have improved post-ischemic myocardial recovery
38. Heat shock and the skin
39. Cardioprotective effects of 70-kD heat stress protein transgenic mice
40. Impaired visual evoked potential and primary axonopathy of the optic nerve in the diabetic BB/W-rat
41. Effects of bimoclomol, the novel heat shock protein coinducer, in dog ventricular myocardium
42. Vascular factors in diabetic neuropathy
43. Endoneurial blood flow and oxygen tension in the sciatic nerves of rats with experimental diabetic neuropathy
44. Bimoclomol: A nontoxic hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects
45. Mammalian stress response: Cell physiology, structure/function of stress proteins, and implications for medicine and disease
46. Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm
47. Stress proteins and myocardial protection
48. Ischemic preconditioning limits infarct size in the rat heart
49. Protective effect of a 21-aminosteroid on the blood-brain barrier following sub-arachnoid hemorrhage in rats