Cell death induced by granzyme C

Blood

Volumn 101, Issue 8, 2003, Pages 3093-3101

  Johnson, Hillary ^b   Scorrano, Luca ^b   Korsmeyer, Stanley J ^b   Ley, Timothy J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CAD PROTEIN; CASPASE; CYCLOSPORIN A; DNA TOPOISOMERASE; GRANZYME A; GRANZYME B; GRANZYME C; ISOENZYME; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG; CYCLOSPORIN; GRANZYME; GZMB PROTEIN, HUMAN; GZMB PROTEIN, MOUSE; GZMC PROTEIN, MOUSE; HYBRID PROTEIN; MEMBRANE LIPID; MEMBRANE PROTEIN; PERFORIN; PORE FORMING CYTOTOXIC PROTEIN; SERINE PROTEINASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVITY; HUMAN; KINETICS; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; ANIMAL; APOPTOSIS; CELL CULTURE; CELL MEMBRANE POTENTIAL; CELL NUCLEUS; COMPARATIVE STUDY; DNA DAMAGE; DRUG EFFECT; ENZYME SPECIFICITY; INTRACELLULAR MEMBRANE; MITOCHONDRION;

ANIMALS; APOPTOSIS; CELL NUCLEUS; CYCLOSPORINE; DNA DAMAGE; GRANZYMES; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE GLYCOPROTEINS; MEMBRANE LIPIDS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; PHOSPHATIDYLSERINES; PORE FORMING CYTOTOXIC PROTEINS; RECOMBINANT FUSION PROTEINS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0038281338     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-08-2485     Document Type: Article

References (51)

1. Kam C-M, Hudig D, Powers JC. Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors. Biochem Biophys Acta. 2000;1477:307-323.
2. Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Ann Rev Immunol. 2002;20:323-370.
3. Simon MM, Hausmann M, Tran T, et al. In vitro and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells. J Exp Med. 1997;186:1781-1786.
4. Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity. 1999;10:595-605.
5. Nakajima H, Park HL, Henkart PA. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J Exp Med. 1995;181:1037-1046.
6. Shi L, Kam CM, Powers JC, Aebersold R, Greenberg AH. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med. 1992;176:1521-1529.
7. Odake S, Kam CM, Narasimhan L, et al. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry. 1991;30:2217-2227.
8. Thornberry NA, Rano TA, Peterson EP, et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B: functional relationships established for key mediators of apoptosis. J Biol Chem. 1997;272:17907-17911.
9. Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 2000;12:621-632.
10. Sharif-Askari E, Alam A, Rheaume E, et al. Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J. 2001;20:3101-3113.
11. Barry M, Heibein JA, Pinkoski MJ, et al. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Mol Cell Biol. 2000;20:3781-3794.
12. Heibein JA, Goping IS, Barry M, et al. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members Bid and Bax. J Exp Med. 2000;192:1391-1402.
13. Sutton VR, Davis JE, Cancilla M, et al. Initiation of apoptosis by granzyme B requires direct cleavage of Bld, but not direct granzyme B-mediated caspase activation. J Exp Med. 2000;192:1403-1413.
14. Alimonti JB, Shi L, Baijal PK, Greenberg AH. Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition. J Biol Chem. 2001;276:6974-6982.
15. Pinkoski MJ, Waterhouse NJ, Heibein JA, et al. Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway. J Biol Chem. 2001;276:12060-12067.
16. Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc Natl Acad Sci U S A. 2001;26:14985-14990.
17. Zhang D, Pasternack MS, Beresford PJ, Wagner L, Greenberg AH, Lieberman J. Induction of rapid histone degradation by the cytotoxic T lymphocyte protease granzyme A. J Biol Chem. 2000;276:3683-3690.
18. Zhang D, Beresford PJ, Greenberg AH, Lieberman J. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001;98:5746-5751.
19. Beresford PJ, Zhang D, Oh DY, et al. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem. 2001;276:43285-43293.
20. Shresta S, Goda P, Wesselschmidt R, Ley TJ. Residual cytotoxicity and granzyme K expression in granzyme A deficient cytotoxic lymphocytes. J Biol Chem. 1997;272:236-244.
21. Hanson RD, Hohn PA, Popescu NC, Ley TJ. A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human α/δ T-cell receptor locus. Proc Natl Acad Sci U S A. 1990;87:960-963.
22. Edwards KM, Kam CM, Powers JC, Trapani JA. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. J Biol Chem. 1999;274:30468-30473.
23. Pham CT, MacIvor DM, Hug BA, Heusel JW, Ley TJ. Long-range disruption of gene expression by a selectable marker cassette. Proc Natl Acad Sci U S A. 1996;93:13090-13095.
24. Heusel JW, Hanson RD, Silverman GA, Ley TJ. Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. J Biol Chem. 1991;266:6152-6158.
25. MacIvor DM, Pham CT, Ley TJ. The 5′ flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice. Blood. 1999;93:963-973.
26. Pham CT, Thomas DA, Mercer JD, Ley TJ. Production of fully active recombinant murine granzyme B in yeast. J Biol Chem. 1998;273:1629-1633.
27. Caputo A, James MN, Powers JC, Hudig D, Bleackley RC. Conversion of the substrate specificity of mouse proteinase granzyme B. Nat Struct Biol. 1994;1:364-367.
28. Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 1994;76:977-987.
29. Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proc Natl Acad Sci U S A. 1995;92:5679-5683.
30. Lecoeur H, Ledru E, Prevost ML, Gougeon ML. Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods. J Immunol Methods. 1997;209:111-123.
31. Beresford PJ, Xia Z, Greenberg AH, Lieberman J. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity. 1999;10:585-594
32. Wei MC, Lindsten T, Mootha VK, et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 2000;14:2060-2171.
33. Huser J, Rechenmacher CE, Blatter LA. Imaging the permeability pore transition in single mitochondria. Biophys J. 1998;74:2129-2137.
34. Chacon E, Ohata H, Harper IS, Trollinger DR, Herman B, Lemasters JJ. Mitochondrial free calcium transients during excitation-contraction coupling in rabbit cardiac myocytes. FEBS Lett. 1996;382:31-36.
35. Lecoeur H, Fevrier M, Garcia S, Riviere Y, Gougeon ML. A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity. J Immunol Methods. 2001;253:177-187.
36. Scorrano L, Ashiya M, Buttle K, et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell. 2002;2:55-67.
37. Bernardi P, Scorrano L, Colonna R, Petronilli V, Di Lisa F. Mitochondria and cell death: mechanistic aspects and methodological issues. Eur J Biochem. 1999;264:687-701.
38. Pfeiffer DR, Gudz TI, Novgorodov SA, Erdahl WL. The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition. J Biol Chem. 1995;270:4923-4932.
39. Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 2001;412:95-99.
40. Joza N, Susin SA, Daugas E, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001;410:549-554.
41. Susin SA, Daugas E, Ravagnan L, et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med. 2000;192:571-580.
42. He L, Lemasters JJ. Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett. 2002;512:1-7.
43. Szabo I, Zoratti M. The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A. J Biol Chem. 1991;266:3376-3379.
44. Ichas F, Jouaville LS, Mazat J-P. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell. 1997;89:1145-1153.
45. Graubert TA, Russell JH, Ley TJ. The role of granzyme B in murine models of acute graft-versus-host-disease and graft rejection. Blood. 1996;87:1232-1237.
46. Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GR. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J Biol Chem. 1995;270:10377-10379.
47. Tewari M, Telford WG, Miller RA, Dixit VM. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic lymphocyte mediated apoptosis. J Biol Chem. 1995;270:22705-22708.
48. Medema JP, de Jong J, Peltenburg LT, et al. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci U S A. 2001;98:11515-11520.
49. Bladergroen BA, Meijer CJ, ten Berge RL, et al. Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood. 2002;99:232-237.
50. Andrade F, Bull HG, Thornberry NA, Ketner GW, Casciola-Rosen L, Rosen A. Adenovirus L4-100K assembly protein is a granzyme B-substrate that potently inhibits granzyme B-mediated cell death. Immmunity 2001;14:751-761.
51. Bailey ND, Kelly CJ. Nephritogenic T cells use granzyme C as a cytotoxic mediator. Eur J Immunol. 1997;9:2302-2309.