Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Blood

Volumn 96, Issue 6, 2000, Pages 2284-2291

  Shiotsu, Y ^a   Neckers, L M ^a   Wortman, I ^a   An, W G ^a   Schulte, T W ^a   Soga, S ^a   Murakata, C ^a   Tamaoki, T ^a   Akinaga, S ^a  

^a NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BCR ABL PROTEIN; GLYCOPHORIN A; HEAT SHOCK PROTEIN 90; HERBIMYCIN A; KF 25706; KF 58333; OXIME DERIVATIVE; PROTEIN P27; PROTEIN TYROSINE KINASE; RADICICOL; RAF PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; ENZYME ACTIVITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0034665760     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2284     Document Type: Article

References (34)

1. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
2. Fused transcript of abl and bcr genes in chronic myelogenous leukemia
3. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
4. A novel abl protein product in Philadelphia-positive acute lymphoblastic leukemia
5. A novel abl protein expressed in Philadelphia chromosome-positive acute lymphoblastic leukemia
6. The molecular genetics of Philadelphia chromosome-positive leukemia
7. Expression of a distinctive BCR-ABL oncogene in Phi-positive lymphocyte leukemia
8. Alternative signals to ras for hematopoietic transformation by the bcr-abl oncogene
9. Tyrphostin-induced inhibition of p210(bcr-abl) tyrosine kinase activity induces K562 to differentiate
10. Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of bcr-abl positive cells
11. Induction of erythroid differentiation of K562 human leukemic cells by herbimycin A, an inhibitor of tyrosine kinase activity
12. Inhibition of oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemic K562 cells
13. Inhibition of heat shock protein hsp90-pp60(v·src) heteroprotein complex formation by benzoquinone ansamycin
14. Crystal structure of an hsp90-geldanamycin complex: Targeting of a protein chaperone by an anti-tumor agent
15. Destabilization of raf-1by by geldanamycin leads to disruption of the raf-1-mek-mitogen-activated protein kinase signalling pathway
16. Binding of benzoquinoid ansamycins to p100 correlates with their ability to deplete the erbB2 gene product p185
17. Steroid receptor interactions with heat shock protein and immunophilin chaperones
18. The physical association Of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90 binding agent
19. Radicicol leads to selective depletion of raf kinase and disrupts K-ras-activated aberrant signaling pathway
20. The antibiotic radicicol to the N-terminal domain of hsp90 and shares important biological activities with geldanamycin
21. Targeting of the protein chaperone, hsp90, by the transformation suppressing agent, radicicol
22. Basic fibroblast growth factor antagonizes transforming growth factor β-mediated erythroid differentiation in K562 cells
23. Inducers of erythroid differentiation in K562 human leukemic cells
24. Exposure of phophatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophage
25. Interaction of radicicol with the heat shock 90 family of molecular chaperones
26. Enhanced cell differentiation when Rb is hypophosphorylated and down-regulated by radicicol, a src-kinase inhibitor
27. Morphology of ras-transformed cells becomes apparently normal again with tyrosine kinase inhibitors without decrease in the ras-GTP complex
28. Radicicol inhibits tyrosine phosphorylation of the mitotic src substrate sam68 and retards subsequent exit from mitosisol src-transformed cells
29. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of hsp90 binding signaling molecules
30. Geldanamycin-induced destabilization of raf-1 involves proteasome
31. Bcr-Abl and Bcr proteins: Biochemical characterization and localization
32. The influence of target protein half-life on the effectiveness of antisense oligonucleotide analog-mediated biologic responses
33. 19-Allylaminoherbimycin A, an analog of herbimycin A that is stable against treatment with thiol compounds or granulocyte-macrophage colony-stimulating factor in human leukemia cells
34. Mammalian p50/cdc37 is a protein kinase-targeting subunit hsp90 that binds and stabilizes cdk4