Hsp72 and stress kinase c-jun N-terminal kinase regulate the Bid-dependent pathway in tumor necrosis factor-induced apoptosis

Molecular and Cellular Biology

Volumn 22, Issue 10, 2002, Pages 3415-3424

  Gabai, Vladimir L ^a   Mabuchi, Katsuhide ^a   Mosser, Dick D ^a   Sherman, Michael Y ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHAPERONE; CYTOCHROME C1; HEAT SHOCK PROTEIN 72; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SPECIFICITY; FIBROBLAST; GENE DELETION; HEAT STRESS; HUMAN; HUMAN CELL; HUMAN TISSUE; KNOCKOUT MOUSE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASES; CELL LINE; CYTOCHROME C GROUP; FIBROBLASTS; HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036234472     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.10.3415-3424.2002     Document Type: Article

References (41)

1. Stress management heat shock protein-70 and the regulation of apoptosis
2. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
3. Biochemical pathways of caspase activation during apoptosis
4. Mutations in the C-terminal fragment of DnaK affecting peptide binding
5. Heat shock protein 72 modulates pathways of stress-induced apoptosis
6. Role of stress-activated protein kinases in endothelin-induced cardiomyocyte hyperthrophy
7. Heat shock protein 70 inhibits caspase-dependent and-independent apoptosis in Jurkat T cells
8. Signal transduction by the JNK group of MAP kinases
9. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
10. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1
11. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance
12. Role of Hsp70 in regulation of stress-kinase JNK: Implication in apoptosis and aging
13. Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation: HSP72 alleviates the stress-induced inhibition of JNK dephosphorylation
14. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death
15. The role of molecular chaperones in protein folding
16. Escaping cell death: Survival proteins in cancer
17. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
18. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation
19. Heat shock protein hsp70 protect cells from thermal stress even after deletion of its ATP-binding domain
20. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
21. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
22. Inducible overexpression of a toxic protein by an adenovirus vector with a tetracycline-regulatable expression cassette
23. Protein damaging stresses activate JNK via inhibition of its phosphatase: A novel pathway controlled by Hsp72
24. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
25. Use of a dicistronic expression cassette encoding the green fluorescent protein for the screening and selection of cells expressing inducible gene products
26. The chaperone function of hsp70 is required for protection against stress-induced apoptosis
27. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase
28. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation
29. Negative regulation of the Apaf-1 apoptosome by Hsp70
30. Heat shock proteins: Regulators of stress response and apoptosis
31. Two CD95 (APO-1/Fas) signaling pathways
32. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
33. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
34. Mitogen- activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
35. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
36. ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis
37. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
38. The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage
39. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
40. The stress-activated protcin kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat