The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma

Carcinogenesis

Volumn 23, Issue 11, 2002, Pages 1781-1789

  Hu, Wenwei ^a   Feng, Zhaohui ^a   Eveleigh, Jamie ^a   Iyer, Ganesh ^a   Pan, Jishen ^b   Amin, Shantu ^b   Chung, Fung Lung ^b   Tang, Moon Shong ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ABC EXCINUCLEASE; DNA; GUANINE; LIPID; NUCLEOTIDE; PROTEIN P53; THYMINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CODON; COMPLEX FORMATION; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; ENZYME ISOLATION; ESCHERICHIA COLI; EXCISION REPAIR; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; HUMAN; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LYMPHOBLASTOID CELL LINE; MOLECULAR INTERACTION; MUTAGENICITY; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 0036850924     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.11.1781     Document Type: Article

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