Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway

Biochemical and Biophysical Research Communications

Volumn 299, Issue 2, 2002, Pages 201-207

  Movsesyan, Vilen A ^a   Yakovlev, Alexander G ^a   Dabaghyan, Elvira A ^a   Stoica, Bogdan A ^a   Faden, Alan I ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Caspases; Ceramide; Cortical neurons; Neuronal death; SH SY5Y

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CELL EXTRACT; CERAMIDE DERIVATIVE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL LEVEL; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DATA ANALYSIS; EMBRYO; ENZYME SUBSTRATE; FLUOROMETRY; FRAGMENTATION REACTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOREACTIVITY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; TREATMENT OUTCOME; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MUTATION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPHINGOSINE; TUMOR CELLS, CULTURED;

EID: 0036436656     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02593-7     Document Type: Article

References (32)

1. R.E. Toman, S. Spiegel, A.I. Faden, Role of ceramide in neuronal cell death and differentiation, J. Neurotrauma 17 (2000) 891-898
2. Y.A. Hannun, C. Luberto, Ceramide in the eukaryotic stress response, Trends Cell Biol. 10 (2000) 73-80
3. R. Goswami, G. Dawson, Does ceramide play a role in neural cell apoptosis?, J. Neurosci. Res. 60 (2000) 141-149
4. Y.A. Hannun, L.M. Obeid, The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind, J. Biol. Chem. 13 (2002) 13
5. Y. Hannun, Functions of ceramide in coordinating cellular responses to stress, Science 274 (1996) 1855-1859
6. A.L. Rose, P.M. Farmer, N. Mitra, K.E. Wisniewski, R.K. Pullarkat, Clinical, pathologic, and neurochemical studies of an unusual case of neuronal storage disease with lamellar cytoplasmic inclusions: A new genetic disorder?, J. Child Neurol. 14 (1999) 123-129
7. V. France-Lanord, B. Brugg, P.P. Michel, Y. Agid, M. Ruberg, Mitochondrial free radical signal in ceramide-dependent apoptosis: A putative mechanism for neuronal death in Parkinson's disease, J. Neurochem. 69 (1997) 1612-1621
8. I. Herr, A. Martin-Villalba, E. Kurz, P. Roncaioli, J. Schenkel, M.G. Cifone, K.M. Debatin, FK506 prevents stroke-induced generation of ceramide and apoptosis signaling, Brain Res. 826 (1999) 210-219
9. Y. Chen, I. Ginis, J.M. Hallenbeck, The protective e7ect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells, J. Cereb. Blood Flow Metab. 21 (2001) 34-40
10. K. Furuya, I. Ginis, H. Takeda, Y. Chen, J.M. Hallenbeck, Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia, J. Cereb. Blood Flow Metab. 21 (2001) 226-232
11. Z.F. Yu, M. Nikolova-Karakashian, D. Zhou, G. Cheng, E.H. Schuchman, M.P. Mattson, Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis, J. Mol. Neurosci. 15 (2000) 85-97
12. R. Toman, V. Movsesyan, S. Murthy, S. Milstien, S. Spiegel, A.I Faden, Ceramide-induced cell death in primary neuronal cultures: Upregulation of ceramide levels during neuronal apoptosis, J. Neurosci. Res. 68 (2002) 323-330
13. L. Colombaioni, L.M. Frago, I. Varela-Nieto, R. Pesi, M. Garcia-Gil, Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells, Neurochem. Int. 40 (2002) 327-336
14. N. Marks, M.J. Berg, A. Guidotti, M. Saito, Activation of caspase-3 and apoptosis in cerebellar granule cells, J. Neurosci. Res. 52 (1998) 334-341
15. M. Saito, A. Guidotti, M.J. Berg, N. Marks, The semisynthetic glycosphingolipid LIGA20 potently protects neurons against apoptosis, Ann. NY Acad. Sci. 845 (1998) 253-262
16. T. Taniwaki, T. Yamada, H. Asahara, Y. Ohyagi, J. Kira, Ceramide induces apoptosis to immature cerebellar granule cells in culture, Neurochem. Res. 24 (1999) 685-690
17. H. Zhou, S.A. Summers, M.J. Birnbaum, R.N. Pittman, Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis, J. Biol. Chem. 273 (1998) 16568-16575
18. D. Pelled, T. Raveh, C. Riebeling, M. Fridkin, H. Berissi, A.H. Futerman, A. Kimchi, Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons, J. Biol. Chem. 277 (2002) 1957-1961
19. V.A. Movsesyan, D.M. O'Leary, L. Fan, W. Bao, P.G. Mullins, S.M. Knoblach, A.I. Faden, mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors, J. Pharmacol. Exp. Ther. 296 (2001) 41-47
20. G. Pan, K. O'Rourke, V.M. Dixit, Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex, J. Biol. Chem. 273 (1998) 5841-5845
21. M.C. Sinensky, A.L. Leiser, H. Babich, Oxidative stress aspects of the cytotoxicity of carbamide peroxide: In vitro studies, Toxicol. Lett. 75 (1995) 101-109
22. S.A. Back, R. Khan, X. Gan, P.A. Rosenberg, J.J. Volpe, A new Alamar blue viability assay to rapidly quantify oligodendrocyte death, J. Neurosci. Methods 91 (1999) 47-54
23. L.M. Obeid, C.M. Lindaric, L.A. Karolak, Y.A. Hannun, Programmed cell death induced by ceramide, Science 259 (1993) 1769-1771
24. J. Mitoma, M. Ito, S. Furuya, Y. Hirabayashi, Bipotential roles of ceramide in the growth of hippocampal neurons: Promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners, J. Neurosci. Res. 51 (1998) 712-722
25. F. Irie, Y. Hirabayashi, Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations, J. Neurosci. Res. 54 (1998) 475-485
26. S. Willaime, P. Vanhoutte, J. Caboche, Y. Lemaigre-Dubreuil, J. Mariani, B. Brugg, Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation, Eur. J. Neurosci. 13 (2001) 2037-2046
27. B.A. Eldadah, A.G. Yakovlev, A.I. Faden, The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells, J. Neurosci. 17 (1997) 6105-6113
28. V.A. Movsesyan, A.G. Yakovlev, L. Fan, A.I. Faden, E7ect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis, Exp. Neurol. 167 (2001) 366-375
29. N. Noshita, A. Lewen, T. Sugawara, P.H. Chan, Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice, J. Cereb. Blood Flow Metab. 21 (2001) 1442-1450
30. M. Dubois-Dauphin, Y. Pfister, P.G. Vallet, A. Savioz, Prevention of apoptotic neuronal death by controlling procaspases? A point of view, Brain Res. Brain Res. Rev. 36 (2001) 196-203
31. A.G. Yakovlev, K. Ota, G. Wang, V. Movsesyan, W.L. Bao, K. Yoshihara, A.I. Faden, Di7erential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury, J. Neurosci. 21 (2001) 7439-7446
32. H. Zhou, X.M. Li, J. Meinkoth, R.N. Pittman, Akt regulates cell survival and apoptosis at a postmitochondrial level, J. Cell Biol. 151 (2000) 483-494