The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability

European Journal of Pharmaceutical Sciences

Volumn 21, Issue 1, 2004, Pages 25-51

  Chan, Lauretta M S ^a   Lowes, Simon ^a   Hirst, Barry H ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

ABC efflux transporters; Intestinal clearance; MDR1 P glycoprotein; MRP; Regulation

Indexed keywords

ABC TRANSPORTER; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARDIAC AGENT; CARRIER PROTEIN; CYCLOSPORIN A; DIGOXIN; GLYCOPROTEIN P; HISTAMINE H2 RECEPTOR ANTAGONIST; IMMUNOSUPPRESSIVE AGENT; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; PACLITAXEL; PROTEIN; PROTEIN PGP; QUINIDINE; SAQUINAVIR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

COLON ABSORPTION; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG CROSS REACTIVITY; DRUG DEGRADATION; DRUG DISPOSITION; DRUG UPTAKE; ENZYME SPECIFICITY; GASTROINTESTINAL ABSORPTION; GENETIC CONSERVATION; HUMAN; IMMUNOCYTOCHEMISTRY; INTESTINE EPITHELIUM; KNOCKOUT MOUSE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SMALL INTESTINE ABSORPTION; SPECIES CONSERVATION;

EID: 0346728729     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2003.07.003     Document Type: Review

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