Correlation of gene expression of ten drug efflux proteins of the atp-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 164-170

  Taipalensuu, Jan ^a   Törnblom, Hans ^c   Lindberg, Greger ^c   Einarsson, Curt ^c   Sjöqvist, Folke ^c   Melhus, Håkan ^b   Garberg, Per ^d   Sjöström, Brita ^d   Lundgren, B O ^d   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d Department of in Vitro Sciences Pharmacia ^*  (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME P450 3A4; LUNG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CELL STRAIN CACO 2; DRUG ABSORPTION; DRUG TRANSPORT; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE EPITHELIUM; JEJUNUM MUCOSA; MONOLAYER CULTURE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; CYTOCHROME P-450 ENZYME SYSTEM; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, MDR; HUMANS; INTESTINES; JEJUNUM; MIXED FUNCTION OXYGENASES; PHARMACEUTICAL PREPARATIONS; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 0034811602     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database
2. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
3. Studying transport processes in absorptive epithelia
4. A family of drug transporters: The multidrug resistance-associated proteins
5. Cell cultures as tools in biopharmacy
6. Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins
7. Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin
8. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
9. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model
10. A multidrug resistance transporter from human MCF-7 breast cancer cells
11. Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers
12. Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation
13. The effect of rifampin treatment on intestinal expression of human MRP transporters
14. Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
15. Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line
16. Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake
17. Function and expression of multidrug resistance-associated protein family in human colon adenoearcinoma cells (Caco-2)
18. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists
19. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
20. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
21. CYP3A gene expression in human gut epithelium
22. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRPS, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
23. MRP3, an organic anion transporter able to transport anti-cancer drugs
24. The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)
25. Interindividual variation in intestinal mdrl expression: Lack of short term diet effects
26. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
27. Transport function and hepatocellular localization of mrp6 in rat liver
28. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
29. pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
30. Expression and localization of multidrug resistant protein mrp2 in rat small intestine
31. Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney
32. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells
33. The drug resistance-related protein LRP is the human major vault protein
34. Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia
35. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
36. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
37. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
38. Localization of villin, a cytoskeletal protein specific to microvilli, in human ileum and colon and in colonic neoplasms
39. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
40. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man - Fact or myth