Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells

Molecular Pharmacology

Volumn 55, Issue 5, 1999, Pages 929-937

  Cui, Yunhai ^a   König, Jörg ^a   Buchholz, Ulrike ^a   Spring, Herbert ^a   Leier, Inka ^a   Keppler, Dietrich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; BUTYRIC ACID; CISPLATIN; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; MULTIDRUG RESISTANCE PROTEIN; RECOMBINANT PROTEIN; TRICHOSTATIN A;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL VIABILITY; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TUMOR CELL;

EID: 0345299165     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T and Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271:15091-15098.
2. Chan CW, Song Y, Ailenberg M, Wheeler M, Pang SF, Brown GM and Silverman M (1997) Studies of melatonin effects on epithelia using the human embryonic kidney-293 (HEK-293) cell line. Endocrinology 138:4732-4739.
3. Chang XB, Hou YX and Riordan JR (1997) ATPase activity of purified multidrug resistance-associated protein. J Biol Chem 272:30962-30968.
4. Chen WY, Bailey EC, McCune SL, Dong JY and Townes TM (1997) Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci USA 94:5798-5803.
5. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM and Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Wash DC) 258: 1650-1654.
6. Dantzig AH, Shepard RL, Cao J, Law KL, Ehlhardt WJ, Baughman TM, Bumol TF and Starling JJ (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res 56: 4171-4179.
7. Evers R, Kool M, van Deemter L, Janssen H, Calafat J, Oomen LCJM, Paulusma CC, Oude Elferink RPJ, Baas F, Schinkel AH and Borst P (1998) Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 101:1310-1319.
8. Evers R, Zaman GJ, van Deemter L, Jansen H, Calafat J, Oomen LC, Oude Elferink RP, Borst P and Schinkel AH (1996) Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J Clin Invest 97:1211-1218.
9. Grant CE, Valdimarsson G, Hipfaer DR, Almquist KC, Cole SPC and Deeley RG (1994) Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54:357-361.
10. Granzow C, Kopun M, and Krober T (1995) Riboflavin-mediated photosensitization of Vinca alkaloids distorts drug sensitivity assays. Cancer Res 55:4837-4843.
11. 2 terminus. J Biol Chem 272:23623-23630.
12. Horio M, Chin KV, Currier SJ, Goldenberg S, Williams C, Pastan I, Gottesman MM and Handler J (1989) Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J Biol Chem 264: 14880-14884.
13. Ishikawa T, Müller M, Klünemann C, Schaub T and Keppler D (1990) ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem 265:19279-19286.
14. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272:G16-G22.
15. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1998) Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 273:1684-1688.
16. Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G and Keppler D (1996) Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res 56:988-994.
17. Jedlitschky G, Leier I, Buchholz U, Center M and Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54:4833-4836.
18. Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B and Keppler D (1997) ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327:305-310.
19. Kartenbeck J, Leuschner U, Mayer R and Keppler D (1996) Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 23:1061-1066.
20. Kast C and Gros P (1997) Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence. J Biol Chem 272:26479-26487.
21. Kast C and Gros P (1998) Epitope insertion favors a six-transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein. Biochemistry 37:2305-2313.
22. Keppler D, Jedlitschky G and Leier I (1998) Transport function and substrate specificity of multidrug resistance protein. Methods Enzymol 292:607-616.
23. Keppler D and Kartenbeck J (1996) The canalicular conjugate export pump encoded by the cmrp l cmoat gene, in Progress in Liver Diseases (Boyer JL and Ockner RK eds) vol 14, pp 55-67, Saunders, Philadelphia.
24. Keppler D and König J (1997) Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/ cMOAT) gene in liver. FASEB J 11:509-516.
25. Koike K, Kawabe T, Tanaka T, Toh S, Uchiumi T, Wada M, Akiyama S, Ono M and Kuwano M (1997) A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res 57:5475-5479.
26. Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F and Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547.
27. 4 and structurally related conjugates. J Biol Chem 269:27807-27810.
28. Lineweaver H and Burk D (1934) The determination of enzyme dissociation constants. J Am Soc 56:658-666.
29. 4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J Biol Chem 271:9675-9682.
30. Madon J, Eckhardt U, Gerloff T, Stieger B and Meier PJ (1997) Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett 406:75-78.
31. Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I and Keppler D (1995) Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 131:137-150.
32. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
33. Müller M, Meijer C, Zaman GZ, Borst P, Scheper RJ, Mulder NH, de Vries EG and Jansen PL (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91:13033-13037.
34. Oude Elferink RP, Meijer DK, Kuipers F, Jansen PL, Groen AK and Groothuis GM (1995) Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
35. Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, Scheffer GL, Scheper RJ, Borst P and Oude Elferink RP (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Wash DC) 271:1126-1128.
36. Paulusma CC, Kool M, Bosma PJ, Scheffer GL, ter Borg F, Scheper RJ,Tytgat GN, Borst P, Baas F and Oude Elferink RP (1997) A mutation in the human canalicular multispecific organic anion transporter gène causes the Dubin-Johnson syndrome. Hepatology 25:1539-1542.
37. Persson B and Argos P (1994) Prediction of transmembrane segments in proteins utilising multiple sequence alignments. J Mol Biol 237:182-192.
38. Richardson JC, Scalera V and Simmons NL (1981) Identification of two strains of MDCK cells which resemble separate nephron tubule segments. Biochim Biophys Acta 673:26-36.
39. Sanger F, Coulson AR, Barrell BG, Smith AJ, and Roe BA (1980) Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol 143:161-178.
40. Schaub TP, Kartenbeck J, König J, Vogel O, Witzgall R, Kriz W and Keppler D (1997) Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol 8:1213-1221.
41. Shepard RL, Tabas L, Gillepsie J, Binkley S, Wrighton S and Dantzig AH (1998) Selectivity of the potent P-glycoprotein modulator, LY335979 (Abstract). Proc Am Assoc Cancer Res 39:362.
42. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S and Kuwano M (1996) A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56:4124-4129.
43. van Aubel RA, van Kuijck MA, Koenderink JB, Deen PM, van Os CH, and Russel FG (1998) Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. Mol Pharmacol 53:1062-1067.
44. Wada M, Toh S, Taniguchi K, Nakamura T, Uchiumi T, Kohno K, Yoshida I, Kimura A, Sakisaka S, Adachi S and Kuwano M (1998) Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum Mol Genet 7:203-207.
45. Zaman GJ, Lankelma J, van Tellingen O, Beijnen J, Dekker H, Paulusma C, Oude Elferink RP, Baas F and Borst P (1995) Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc Natl Acad Sci USA 92:7690-7694.