Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters

Toxicology

Volumn 167, Issue 1, 2001, Pages 3-23

  Leslie, Elaine M ^a   Deeley, Roger G ^a   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

ATP binding cassette transporter; Carcinogen metabolism; Multidrug resistance protein; Xenobiotic transport; Xenotoxin elimination

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; ENVIRONMENTAL CHEMICAL; FLAVONOID; FOLIC ACID ANTAGONIST; GLUCURONIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; HEAVY METAL; HERBICIDE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; MULTIDRUG RESISTANCE PROTEIN 7; MYCOTOXIN; NATURAL PRODUCT; NITROSAMINE; SULFATE; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 1; SULFONYLUREA RECEPTOR 2; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT;

AMINO ACID SEQUENCE; ARABIDOPSIS; CELL VACUOLE; CHEMICAL STRUCTURE; DETOXIFICATION; HUMAN; LIPID PEROXIDATION; LUNG SMALL CELL CANCER; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; REVIEW; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION; YEAST;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT, ACTIVE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLUTATHIONE; HUMANS; METABOLIC DETOXICATION, DRUG; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; XENOBIOTICS;

ARABIDOPSIS THALIANA; NEMATODA; NICOTIANA TABACUM; TRACHEOPHYTA;

EID: 0035813012     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00454-1     Document Type: Review

References (150)

1. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance
2. Membrane topology and glycosylation of the human multidrug resistance-associated protein
3. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
4. Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione
5. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
6. Characterization of the enzymatic and nonenzymatic reaction of 13-oxooctadecadienoic acid with glutathione
7. Specific protein targets of 13-oxooctadecadienoic acid (13-OXO) and export of the 13-OXO-glutathione conjugate in HT-29 cells
8. The multidrug resistance protein family
9. A family of drug transporters: The multidrug resistance-associated proteins
10. Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium
11. Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans
12. The ABCs of ATP-sensitive potassium channels: More pieces of the puzzle
13. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
14. ATPase activity of purified multidrug resistance-associated protein
15. Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells
16. Multidrug resistance mediated by the ATP-binding cassette transporter protein, MRP
17. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
18. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
19. Major photoaffinity drug binding sites in MRP1 are within TM10-11 and TM16-17
20. Complete inventory of the yeast ABC proteins
21. Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressing glutathione S-transferase P1-1 and/or multidrug resistance protein 1
22. Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1
23. Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
24. Tissue distribution of the multidrug resistance-associated protein
25. Human MRP3 transporter: Identification of the 5′-flanking region, genomic organization and alternative splice variants
26. Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1
27. Pathways of As(III) detoxification in Saccharomyces cerevisiae
28. Sulfotransferases in the bioactivation of xenobiotics
29. Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport
30. ABC transporters: From microorganisms to man
31. Dialkylquinoneimine metabolites of chloroacetanilide herbicides induce sister chromatid exchanges in culture human lymphocytes
32. 2-terminus
33. Structural, mechanistic and clinical aspects of MRP1
34. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)
35. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats
36. The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress
37. Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein
38. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
39. Potent interaction of flavopiridol with MRP1
40. The effect of glutathione on the ATPase activity of MRP1 in its natural membranes
41. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily
42. Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1
43. Crystal structure of the ATP-binding subunit of an ABC transporter
44. Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport
45. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
46. The multidrug resistance resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
47. Dialkylquinonimines validated as in vivo metabolites of alachlor, acetochlor, and metolachlor herbicides in rats
48. The pharmacological phenotype of combined multidrug-resistance mdr1a/1b and mrp1-deficient mice
49. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
50. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
51. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
52. An inventory of the human ABC proteins
53. A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells
54. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
55. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity and MRP2-mediated drug resistance
56. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
57. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
58. MRP3, an organic anion transporter able to transport anti-cancer drugs
59. Intake of flavonoids and lung cancer
60. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter
61. Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells
62. 4 and structurally related conjugates
63. ATP-dependent glutathione disulfide transport mediated by the MRP gene-encoded conjugate export pump
64. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids
65. Transport of the β-O-Glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog
66. Enhanced multispecificity of Arabidopsis vacuolar MRP-type ABC transporter, AtMRP2
67. 4 and chemotherapeutic agents in membrane vesicles: Demonstration of glutathione-dependent vincristine transport
68. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein: Inhibition by cholestatic steroids
69. 1 and its glutathione conjugates by the product of the MRP gene
70. Characterization of vincristine transport by the 190 kDa multidrug resistance protein, MRP: Evidence for co-transport with reduced glutathione
71. Verapamil stimulates glutathione transport by the multidrug resistance protein 1 (MRP1)
72. 4 and reduced glutathione by multidrug resistance protein MRP1
73. Double knockout of the MRP gene leads to increased drug sensitivity in vitro
74. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
75. Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats
76. AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: Isolation and functional definition of a plant ATP-binding cassette transporter gene
77. AtMRP2, an arabidopsis ATP binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: Functional comparisons with AtMRP1
78. Transport function and hepatocellular localization of mrp6 in rat liver
79. ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells
80. Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phopholipid vesicles
81. ATP-dependent glutathione S-conjugate 'export' pump in the vacuolar membrane of plants
82. 1 carcinogenicity
83. ATP binding properties of the nucleotide-binding folds of SUR1
84. pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
85. Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity
86. Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells
87. Expression and localization of multidrug resistant protein mrp2 in rat small intestine
88. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
89. Glucuronidation of 4-((hydroxymethyl)nitrosamino)-1-(3-pyridyl)-1-butanone, a metabolically activated form of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, by phenobarbital-treated rats
90. Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1
91. Differential function of the two nucleotide binding domains on cystic fibrosis transmembrane conductance regulator
92. The influence of coordinate overexpression of glutathione Phase II detoxification gene products on drug resistance
93. Characterization of inducible nature of MRP3 in rat liver
94. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte
95. Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance
96. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
97. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man
98. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
99. Role of the multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance: Kinetics of gluathione conjugate formation and efflux govern differential cellular sensitivitiy to chlorambucil versus melphalan toxicity
100. Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney
101. Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump
102. Glutathione stimulate sulfated estrogen transport by multidrug resistance protein 1
103. Choroid plexus epithelial expression of MDR1 P-glycoprotein and multidrug resistance- associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier
104. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
105. New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models
106. From vacuolar GS-X pumps to multispecific ABC transporters
107. ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
108. Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal
109. Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
110. Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions
111. The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells
112. The structure of the multidrug resistance protein 1 (MRP1/ABCC1): Crystallization and single-particle analysis
113. Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells
114. Cloning and expression analyses of AtMRP4, a novel MRP-like gene from Arabidopsis thaliana
115. The "Arabidopsis thaliana" ABC protein superfamily: A complete inventory
116. Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma
117. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
118. Mice lacking the multidrug resistance protein 1 are resistant to streptococcus pneumoniae-induced pneumonia
119. Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies
120. Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart
121. Expression of members of the multidrug resistance protein family in human term placenta
122. Characterization of the 5′-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 2 (MRP3) gene
123. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
124. Structure and expression of the mRNA encoding the murine multidrug resistance protein (MRP), an ATP-binding cassette transporter
125. Pharmacological characterization of the murine and human orthologs of multidrug resistance protein in transfected human embryonic kidney cells
126. Localization of a substrate specificity domain in the multidrug resistance protein
127. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
128. cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line
129. A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein
130. Characterization of 5′-flanking region of human MRP3
131. Differential expression of genes coding for ABC transporters after treatment of Arabidopsis thaliana with xenobiotics
132. An ABC-transporter of Arabidopsis thaliana has both glutathione-conjugate and chlorophyll catabolite transport activity
133. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells
134. Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine
135. Glutathione conjugation as a bioactivation reaction
136. Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells
137. Efflux of dietary flavonoid quercetin 4′-O-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2
138. Distantly related sequences in the a- and b-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
139. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2
140. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
141. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
142. Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage
143. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
144. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
145. Immunohistochemical detection of multidrug resistance protein (MRP) in human lung cancer and normal lung
146. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump
147. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
148. Identification of an amino acid residue in multidrug resistance protein (MRP) 1 critical for conferring resistance to anthracyclines
149. A structure-based mechanism for drug binding by multidrug transporters