Identification of residues in the drug-binding site of human P- glycoprotein using a thiol-reactive substrate

Journal of Biological Chemistry

Volumn 272, Issue 51, 1997, Pages 31945-31948

  Loo, Tip W ^b   Clarke, David M ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BROMOBIMANE; COLCHICINE; GLYCOPROTEIN P; VERAPAMIL; VINBLASTINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATASES; BICYCLO COMPOUNDS; COLCHICINE; CYSTEINE; ENZYME INHIBITORS; HUMANS; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEIN; SULFHYDRYL COMPOUNDS; VERAPAMIL; VINBLASTINE;

EID: 0031434236     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.51.31945     Document Type: Article

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