In vitro and in vivo investigations on fluoroquinolones; Effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin

European Journal of Pharmaceutical Sciences

Volumn 12, Issue 2, 2000, Pages 85-93

  De Lange, Elizabeth C M ^a   Marchand, Sandrine ^b   Van den Berg, Dirk Jan ^a   Van der Sandt, Inez C J ^a   Ve Boer, Albertus G ^a   Delon, Annie ^b   Bouquet, Serge ^b   Couet, William ^b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UPRES EA 1223   (France)

Author keywords

Blood brain barrier; Dynamic no net flux; Fluoroquinolones; In vitro transport; In vivo recovery; Intracerebral microdialysis; LLC PK1 cells; mdr1a ( ) mice; P Glycoprotein; Sparfloxacin

Indexed keywords

CINOXACIN; CIPROFLOXACIN; FLEROXACIN; GLYCOPROTEIN P; LOMEFLOXACIN; NORFLOXACIN; PEFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RHODAMINE 123; SPARFLOXACIN; VALSPODAR; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG TRANSPORT; EPITHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SWINE;

4-QUINOLONES; ANIMALS; ANTI-INFECTIVE AGENTS; ANTITUBERCULAR AGENTS; BIOLOGICAL TRANSPORT; BRAIN; CELL LINE; CIPROFLOXACIN; FLEROXACIN; FLUOROQUINOLONES; INFUSIONS, INTRA-ARTERIAL; KIDNEY; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICRODIALYSIS; NORFLOXACIN; P-GLYCOPROTEIN; RECOMBINANT PROTEINS; RHODAMINE 123; SWINE; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 0033743228     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00149-4     Document Type: Article

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