Export pumps for anionic conjugates encoded by MRP genes

Advances in Enzyme Regulation

Volumn 39, Issue 1, 1999, Pages 237-246

  Keppler, Dietrich ^a   Cui, Yunhai ^a   König, Jörg ^a   Leier, Inka ^a   Nies, Anne ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ANION TRANSPORT PROTEINS; CARRIER PROTEIN; ETOPOSIDE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN; VINCRISTINE;

ANIMAL; ANIMAL CELL; ANION TRANSPORT; ARABIDOPSIS; CAENORHABDITIS ELEGANS; CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DOG; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; HUMAN CELL; IN VITRO STUDY; ION TRANSPORT; KINETICS; MEMBRANE TRANSPORT; METABOLISM; MOUSE; MULTIDRUG RESISTANCE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PHYSIOLOGY; RABBIT; RAT; SACCHAROMYCES CEREVISIAE;

EID: 0032855145     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(98)00015-6     Document Type: Conference Paper

References (40)

1. S. P. C. COLE, G. BHARDWAJ, J. H. GERLACH, J. E. MACKIE, C. E. GRANT, K. C. ALMQUIST, A. J. STEWART, E. U. KURZ, A. M. V. DUNCAN and R. G. DEELEY, Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line, Science 258, 1650-1654 (1992).
2. 4 export carrier in mastocytoma cells, Eur. J. Biochem. 220, 599-606 (1994).
3. G. JEDLITSCHKY, I. LEIER, U. BUCHHOLZ, M. CENTER and D. KEPPLER, ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein, Cancer Res. 54, 4833-4836 (1994).
4. 4 and structurally related conjugates, J. Biol. Chem. 269, 27807-27810 (1994).
5. R. MAYER, J. KARTENBECK, M. BÜCHLER, G. JEDLITSCHKY, I. LEIER and D. KEPPLER, Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes, J. Cell Biol. 131, 137-150 (1995).
6. C. C. PAULUSMA, P. J. BOSMA, G. J. R. ZAMAN, C. T. M. BAKKER, M. OTTER, G. L. SCHEFFER, R. J. SCHEPER, P. BORST and R. P. J. OUDE ELFERINK, Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene, Science 271, 1126-1128 (1996).
7. M. BÜCHLER, J. KÖNIG, M. BROM, J. KARTENBECK, H. SPRING, T. HORIE and D. KEPPLER, cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats, J. Biol. Chem. 271, 15091-15098 (1996).
8. K. ITO, H. SUZUKI, T. HIROHASHI, K. KUME, T. SHIMIZU and Y. SUGIYAMA, Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR, Am. J. Physiol. 272, G16-G22 (1997).
9. K. TANIGUCHI, M. WADA, K. KOHNO, T. NAKAMURA, T. KAWABE, M. KAWAKAMI, K. KAGOTANI, K. OKUMURA, S. AKIYAMA and M. KUWANO, A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation, Cancer Res. 56, 4124-4129 (1996).
10. M. KOOL, M. DE HAAS, G. L. SCHEFFER, R. J. SCHEPER, M. J. VAN EIJK, J. A. JUIJN, F. BAAS and P. BORST, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines, Cancer Res. 57, 3537-3547 (1997).
11. J. MADON, U. ECKHARDT, T. GERLOFF, B. STIEGER and P. J. MEIER, Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein, FEBS Lett. 406, 75-78 (1997).
12. K. ITO, H. SUZUKI, T. HIROHASHI, K. KUME, T. SHIMIZU and Y. SUGIYAMA, Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver, J. Biol. Chem. 273, 1684-1688 (1998).
13. R. EVERS, M. KOOL, L. VAN DEEMTER, H. JANSSEN, J. CALAFAT, L. C. J. M. OOMEN, C. C. PAULUSMA, R. P. J. OUDE ELFERINK, F. BAAS, A. H. SCHINKEL and P. BORST, Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA, J. Clin. Invest. 101, 1310-1319 (1998).
14. R. A. VAN AUBEL, M. A. VAN KUIJCK, J. B. KOENDERINK, P. M. DEEN, C. H. VAN OS and R. G. RÜSSEL, Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells, Mol. Pharmacol. 53, 1062-1067 (1998).
15. D. KEPPLER and J. KÖNIG, Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver, FASEB J. 11, 509-516 (1997).
16. T. ISHIKAWA, Z-S. LI, Y-P. LU and P. A. REA, The GS-X pump in plant, yeast, and animal cells: structure, function, and gene expression, Bioscience Reports 17, 189-207 (1997).
17. P. A. REA, Z-S. LI, Y-P. LU and Y. M. DROZDOWICZ, From vacuolar GS-X pumps to multispecific ABC transporters, Annu. Rev. Plant Physiol. Plant Mol. Biol. 49, 727-760 (1998).
18. W. Y. CHEN, E. C. BAILEY, S. L. MCCUNE, J. Y. DONG and T. M. TOWNES, Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase, Proc. Natl. Acad. Sci. U.S.A. 94, 5798-5803 (1997).
19. D. KEPPLER, G. JEDLITSCHKY and I. LEIER, Transport function and substrate specificity of multidrug resistance protein, Methods Enzymol. 292, 607-616 (1998).
20. A. T. NIES, T. CANTZ, M. BROM, I. LEIER and D. KEPPLER, Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B, Hepatology 28, 1332-1340 (1998).
21. T. MOSMANN, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J. Immunol. Methods 65, 55-63 (1983).
22. T. KONDO, G. L. DALE and E. BEUTLER, Glutathione transport by inside-out vesicles from human erythrocytes, Proc. Natl. Acad. Sci. U.S.A. 77, 6359-6362 (1980).
23. T. KONDO, M. MURAO and N. TANIGUCHI, Glutathione S-conjugate transport using inside-out vesicles from human erythrocytes, Eur. J. Biochem. 125, 551-554 (1982).
24. K. KOBAYASHI, Y. SOGAME, K. HAYASHI, P. NICOTERA and S. ORRENIUS, ATP stimulates the uptake of S-dinitrophenylglutathione by rat liver plasma membrane vesicles, FEBS Lett. 240, 55-58 (1988).
25. T. ISHIKAWA, M. MÜLLER, C. KLÜNEMANN, T. SCHAUB and D. KEPPLER, ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates, J. Biol. Chem. 265, 19279-19286 (1990).
26. M. MÜLLER, C. MEIJER, G. J. R. ZAMAN, P. BORST, R. J. SCHEPER, N. H. MULDER, E. G. E. DE VRIES and P. L. M. JANSEN, Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport, Proc. Natl. Acad. Sci. USA 91, 13033-13037 (1994).
27. G. JEDLITSCHKY, I. LEIER, U. BUCHHOLZ, K. BARNOUIN, G. KURZ and D. KEPPLER, Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump, Cancer Res. 56, 988-994 (1996).
28. G. JEDLITSCHKY, I. LEIER, U. BUCHHOLZ, J. HUMMEL-EISENBEISS, B. BURCHELL and D. KEPPLER, ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2, Biochem. J. 327, 305-310 (1997).
29. D. W. LOE, K. C. ALMQUIST, S. P. C. COLE and R. G. DEELEY, ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids, J. Biol. Chem. 271, 9683-9689 (1996).
30. T. P. SCHAUB, J. KARTENBECK, J. KÖNIG, O. VOGEL, R. WITZGALL, W. KRIZ and D. KEPPLER, Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules, J. Am. Soc. Nephrol. 8, 1213-1221 (1997).
31. Y. KIUCHI, H. SUZUKI, T. HIROHASHI, C. A. TYSON and Y. SUGIYAMA, cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3), FEBS Letters 433, 149-152 (1998).
32. T. HIROHASHI, H. SUZUKI, K. ITO, K. OGAWA, K. KUME, T. SHIMIZU and Y. SUGIYAMA, Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats, Mol. Pharmacol. 53, 1068-1075 (1998).
33. Z. S. LI, M. SZCZYPKA, Y. P. LU, D. J. THIELE and P. A. REA, The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump, J. Biol. Chem. 271, 6509-6517 (1996).
34. Y. P. LU, Z. S. LI and P. A. REA, AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene, Proc. Natl. Acad. Sci. U.S.A. 94, 8243-8248 (1997).
35. Y. P. LU, Z. S. LI, Y. M. DROZDOWICZ, S. HORTENSTEINER, E. MARTINOIA and P. A. REA, AtMRP2, an Arabidopsis ATP binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with AtMRP1, Plant Cell 10, 267-282 (1998).
36. A. BROEKS, B. GERRARD, R. ALLIKMETS, M. DEAN and R. H. PLASTERK, Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans, EMBO J. 15, 6132-6143 (1996).
37. D. KEPPLER, J. KÖNIG and M. BÜCHLER, The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes, Advanc. Enzyme Regul. 37, 321-333 (1997).
38. M. SENGER, K. H. GLATTING, O. RITTER and S. SUHAI, X-HUSAR, an X-based graphical interface for the analysis of genomic sequences, Comput. Methods Programs Biomed. 46, 131-141 (1995).
39. D. W. LOE, R. G. DEELEY and S. P. C. COLE, Biology of the multidrug resistance-associated protein, MRP, Eur. J. Cancer 32A, 945-957 (1996).
40. I. LEIER, G. JEDLITSCHKY, U. BUCHHOLZ, M. CENTER, S. P. C. COLE, R. G. DEELEY and D. KEPPLER, ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump, Biochem. J. 314, 433-437 (1996).