Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter

Molecular Pharmacology

Volumn 56, Issue 6, 1999, Pages 1219-1228

  Chen, Zhe Sheng ^a   Kawabe, Takeshi ^b   Ono, Mayumi ^b   Aoki, Shunji ^a,c   Sumizawa, Tomoyuki ^a   Furukawa, Tatsuhiko ^a   Uchiumi, Takeshi ^b   Wada, Morimasa ^b   Kuwano, Michihiko ^b   Akiyama, Shin Ichi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (DIPHENYLMETHYL) 1 PIPERAZINYL] 5 (4,6 DIMETHYL 1,3,2 DIOXAPHOSPHORINAN 2 YL) 2,6 DIMETHYL 4 (3 NITROPHENYL) 3 PYRIDINECARBOXYLATE P OXIDE; 5 (4,6 DIMETHYL 1,3,2 DIOXAPHOSPHORINAN 2 YL) 2,6 DIMETHYL 4 (3 NITROPHENYL) 3 PYRIDINECARBOXYLIC ACID 2 (4 BENZHYDRYL 1 PIPERAZINYL)ETHYL ESTER P OXIDE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; CISPLATIN; CYCLOSPORIN A; DOXORUBICIN; ETOPOSIDE; IRINOTECAN; PACLITAXEL; UNCLASSIFIED DRUG; VALSPODAR; VERLUKAST; VINCRISTINE;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; HUMAN; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032753749     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.6.1219     Document Type: Article

References (45)

1. Akiyama S, Fojo JA, Hanover JA, Pastan IH and Gottesman MM (1985) Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat Cell Mol Genet 11:117-126.
2. Awasthi YC, Garg HS, Dao DD, Partridge CA and Arivastava SK (1981) Enzymatic conjugation of erythrocyte glutathione with 1-chloro-2,4-dinitrobenzene: The fate of glutathione conjugate in erythrocytes and the effect of glutathione depletion on hemoglobin. Blood 58:733-738.
3. Barrand MA, Rhodes T, Center MS and Twentyman PR (1993) Chemosensitisation and drug accumulation effects of cyclosporin A, PSC83 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein. Eur J Cancer 29:408-415.
4. Boesch D, Gaveraux C, Jachez B, Pourtier-Manzanedo A, Bollinger P and Loor F (1991) In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res 51:4226-4233.
5. Böhme M, Büchler M, Müller M and Keppler D (1993) Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane. FEBS Lett 333:193-196.
6. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Blochem 72:248-254.
7. Chen Z-S, Mutoh M, Sumizawa T, Furukawa T, Haraguchi M, Tani A and Akiyama S (1997) Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells. Biochem Biophys Res Commun 236:586-590.
8. Chen Z-S, Mutoh M, Sumizawa T, Furukawa T, Haraguchi M, Tani A, Saijo N, Kondo T and Akiyama S (1998) An active efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells. Exp Cell Res 240:312-320.
9. Chu X-Y, Kato Y and Sugiyama Y (1997) Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res 57:1934-1938.
10. Chu X-Y, Kato Y, Ueda K, Suzuki H, Niinuma K, Tyson CA, Weizer V, Dabbs JE, Froehlich R, Green CE and Sugiyama Y (1998) Biliary excretion mechanism of CPT-11 and its metabolites in humans: Involvement of primary active transporters Cancer Res 58:5137-5143.
11. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV and Deeley GR (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Wash DC) 258:1650-1654.
12. Cornwell MM, Gottesman MM and Pastan IH (1986) Increased vincristine binding to membrane vesicles from multidrug-resistant KB cells. J Biol Chem 261:7921-7928.
13. Endicott JA and Ling V (1989) The biochemistry of O-glycoprotein-mediated multi-drug resistance. Annu Rev Biochem 58:137-171.
14. Evers R, Kool M, Deemter LV, Janssen H, Calafat J, Oomen LCJM, Paulusma CC, Oude Elferink RPJ, Baas F, Schinkel AH and Borst P (1998) Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 101:1310-1319.
15. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427.
16. Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SPC and Deeley RG (1994) Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54:357-361.
17. 2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles. J Biol Chem 264: 17343-17348.
18. Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17:463-468.
19. Ishikawa T and Ali-Osman F (1993) Glutathione-associated cis-diamminedichloroplatinum (II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J Biol Chem 268:20116-20125.
20. Ishikawa T, Bao J-J, Yamane Y, Akimaru K, Frindrich K, Wright CD and Kuo MT (1996) Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J Biol Chem 271:14981-14988.
21. Ishikawa T, Muller M, Klunemann C, Schaub T and Keppler D (1990) ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem 265:19279-19286.
22. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyam Y (1998) Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 273:1684-1688.
23. Jansen PLM, Peters WH and Lamers WH (1985) Hereditary chronic conjugated hyperbilirubinemic mutant rats caused by defective hepatic anion transport. Hepatology 5:573-579.
24. Jedlitschky G, Leier I, Buchholz U, Center M and Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54:4833-4836.
25. 4 receptor antagonist. Can J Physiol Pharmacol 67:17-28.
26. Kamimoto Y, Gatmaitan Z, Hsu J and Arias IM (1989) The function of GP170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem 264:11693-11698.
27. Kawabe T, Chen Z-S, Wada M, Uchiumi T, Ono M, Akiyama S and Kuwano M (1999) Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett 456: 327-331.
28. Keppler D and König J (1997) Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASAB J 11:509-516.
29. Koike K, Kawabe T, Tanaka T, Toh S, Uchiumi T, Wada M, Akiyama S, Ono M and Kuwano M (1997) A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res 57:5475-5479.
30. Kool M, de Haas M, Scheffer GL., Scheper RJ, van Eijk MJT, Juijn J, Baas F and Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547.
31. Leier I, Jedlitschky G, Bucholz U, Cole SPC, Deeley GR and Keppler D (1994) The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269:27807-27810.
32. Loe DW, Almquist KC, Deeley RG and Cole SPC (1996) Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J Biol Chem 271:9675-9682.
33. Matsunaga T, Shirasawa H, Hishiki T, Enomoto H, Kouchi K, Ohtsuka Y, Iwai J, Yoshida H, Tanabe M, Kobayashi S, Asano T, Etoh T, Nishi Y and Ohnuma N (1998) Expression of MRP and cMOAT in childhood neuroblastomas and malignant liver tumors and its relevance to clinical behavior. Jpn J Cancer Res 89: 1276-1283.
34. Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I and Keppler D (1995) Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 131:137-150.
35. Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK and Groothuis GMM (1995) Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
36. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P and Oude Elferink RPJ (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Wash DC) 271:1126-1128.
37. Samuels BL, Hollis DR, Rosner GL, Trump DL, Shapiro CL, Vogelzang N J and Schilsky RL (1997) Modulation of vinblastine resistance in metastatic renal cell carcinoma with cyclosporine A or tamoxifen: A cancer and leukemia group B study. Clin Cancer Res 3:1977-1984.
38. Stiff PJ, Bayer R, Tan S, Camarda M, Sosman J, Peace D, Kinch L, Rad N and Loutfi S (1995) High-dose chemotherapy combined with escalating doses of cyclosporin A and an autologous bone marrow transplant for the treatment of drug-resistant solid tumors: A phase I clinical trial. Clin Cancer Res 1:1495-1502.
39. Sumizawa T, Chen Z-S, Chuman Y, Seto K, Furukawa T, Haraguchi M, Tani A, Shudo N and Akiyama S (1997) Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. Mol Pharmacol 61:399-405.
40. Taguchi Y, Yoshida A, Takada Y, Komano T and Ueda K (1997) Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP). FEBS Lett 401:11-14.
41. Takikawa H, Sano N, Marita T, Uchida Y, Yamanaka M, Horie T, Mikami T and Tagaya O (1991) Biliary excretion of bile acid conjugate in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology 14:352-360.
42. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S and Kuwano M (1996) A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56:4124-4129.
43. Versantvoort CHM, Broxterman HJ, Bagrij T and Twentyman PR (1994) Reversal of drug resistance in MRP overexpressing multidrop resistant human lung tumor cells (Abstract). Anticancer Drugs 5:30.
44. Zaman GJR, Flens MJ, van Leusden MR, de Haas M, Mÿlder HS, Lankelma J, Pinedo HM, Scheper RJ, Baas F, Broxterman HJ and Borst P (1994) The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA 91:8822-8826.
45. MOLECULAR PHARMACOLOGY, 56:1229-1237 (1999).