메뉴 건너뛰기




Volumn 48, Issue 10, 1996, Pages 1083-1089

Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

Author keywords

[No Author keywords available]

Indexed keywords

ACEBUTOLOL; ACETAMIDE; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CELIPROLOL; CYCLOSPORIN; GLYCOPROTEIN P; MANNITOL; MONOCLONAL ANTIBODY; NADOLOL; QUINIDINE; TIMOLOL; VINBLASTINE;

EID: 0029800447     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb05904.x     Document Type: Article
Times cited : (223)

References (37)
  • 2
    • 0023205811 scopus 로고
    • The cell biology of multiple drug resistance
    • Beck, W. T. (1987) The cell biology of multiple drug resistance. Biochem. Pharmacol. 36: 2879-2887
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 2879-2887
    • Beck, W.T.1
  • 3
    • 0026015774 scopus 로고
    • Physiologic modeling of cyclosporin kinetics in rat and man
    • Bernareggi, A., Rowland, M. (1991) Physiologic modeling of cyclosporin kinetics in rat and man. J. Pharmacokin. Biopharm. 19: 21-50
    • (1991) J. Pharmacokin. Biopharm. , vol.19 , pp. 21-50
    • Bernareggi, A.1    Rowland, M.2
  • 4
    • 0027267598 scopus 로고
    • Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells
    • Burton, P. S., Conradi, R. A., Hilgers, A. R., Ho, N. F. H. (1993) Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells. Biochem. Biophys. Res. Commun. 190: 760-766
    • (1993) Biochem. Biophys. Res. Commun. , vol.190 , pp. 760-766
    • Burton, P.S.1    Conradi, R.A.2    Hilgers, A.R.3    Ho, N.F.H.4
  • 5
    • 0027345980 scopus 로고
    • Structure and function of P-glycoprotein in normal liver and small intestine
    • Gatmaitan, Z. C., Arias, I. M. (1993) Structure and function of P-glycoprotein in normal liver and small intestine. Adv. Pharmacol. 24: 77-97
    • (1993) Adv. Pharmacol. , vol.24 , pp. 77-97
    • Gatmaitan, Z.C.1    Arias, I.M.2
  • 7
    • 0027818964 scopus 로고
    • Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney
    • Hori, R., Okamura, N., Aiba, T., Tanigawara, Y. (1993) Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney. J. Pharmacol. Exp. Ther. 266: 1620-1625
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , pp. 1620-1625
    • Hori, R.1    Okamura, N.2    Aiba, T.3    Tanigawara, Y.4
  • 8
    • 0026500180 scopus 로고
    • The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa
    • Hsing, S., Gatmaitan, Z., Arias, I. M. (1992) The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology 102: 879-885
    • (1992) Gastroenterology , vol.102 , pp. 879-885
    • Hsing, S.1    Gatmaitan, Z.2    Arias, I.M.3
  • 9
    • 0025912228 scopus 로고
    • Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
    • Hunter, J., Hirst, B. H., Simmons, N. L. (1991) Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein. Br. J. Cancer 64: 437-444
    • (1991) Br. J. Cancer , vol.64 , pp. 437-444
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 10
    • 0027180795 scopus 로고
    • Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
    • Hunter, J., Hirst, B. H., Simmons, N. L. (1993) Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 10: 743-749
    • (1993) Pharm. Res. , vol.10 , pp. 743-749
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 12
    • 0025972011 scopus 로고
    • Modulation by verapamil of vincristine pharmacokinetics and sensitivity to metaphase arrest of the normal rat colon in organ culture
    • Ince, P., Elliott, K., Appleton, D. R., Moorghen, M., Finney, K. J., Sunter, J. P., Harris, A. L., Watson, A. J. (1991). Modulation by verapamil of vincristine pharmacokinetics and sensitivity to metaphase arrest of the normal rat colon in organ culture. Biochem. Pharmacol. 41: 1217-1225
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 1217-1225
    • Ince, P.1    Elliott, K.2    Appleton, D.R.3    Moorghen, M.4    Finney, K.J.5    Sunter, J.P.6    Harris, A.L.7    Watson, A.J.8
  • 13
    • 0027146389 scopus 로고
    • Transport of celiprolol across human intestinal epithelial (Caco-2) cells: Mediation of secretion by multiple transporters including P-glycoprotein
    • Karlsson, J., Kuo, S.-M., Ziemniak, J., Artursson, P. (1993) Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol. 110: 1009-1016
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 1009-1016
    • Karlsson, J.1    Kuo, S.-M.2    Ziemniak, J.3    Artursson, P.4
  • 14
    • 0018850819 scopus 로고
    • Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
    • Komiya, I., Park, J. Y., Kamani, A., Ho, N. F. H., Higuchi, W. I. (1980) Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int. J. Pharm. 4: 249-262
    • (1980) Int. J. Pharm. , vol.4 , pp. 249-262
    • Komiya, I.1    Park, J.Y.2    Kamani, A.3    Ho, N.F.H.4    Higuchi, W.I.5
  • 15
    • 0028303363 scopus 로고
    • The contribution of intestinal secretion to the dose-dependent absorption of celiprolol
    • Kuo, S.-M, Whitby, B. R., Artursson, P., Ziemniak, J. A. (1994) The contribution of intestinal secretion to the dose-dependent absorption of celiprolol. Pharm. Res. 11: 648-653
    • (1994) Pharm. Res. , vol.11 , pp. 648-653
    • Kuo, S.-M.1    Whitby, B.R.2    Artursson, P.3    Ziemniak, J.A.4
  • 16
    • 0028801904 scopus 로고
    • Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
    • Leu, B.-L., Huang, J. D. (1995) Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother. Pharmacol. 35: 432-436
    • (1995) Cancer Chemother. Pharmacol. , vol.35 , pp. 432-436
    • Leu, B.-L.1    Huang, J.D.2
  • 18
    • 0019422355 scopus 로고
    • A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry
    • Martin, Y. C. (1981) A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry. J. Med. Chem. 24: 229-237
    • (1981) J. Med. Chem. , vol.24 , pp. 229-237
    • Martin, Y.C.1
  • 19
    • 0025991880 scopus 로고
    • P-glycoprotein content and mediation of vincristine efflux: Correlation with the level of differentiation in luminal epithelium of mouse small intestine
    • Meyers, M. B., Scotto, K. W., Sirotnak, F. M. (1991) P-glycoprotein content and mediation of vincristine efflux: correlation with the level of differentiation in luminal epithelium of mouse small intestine. Cancer Commun. 3: 159-165
    • (1991) Cancer Commun. , vol.3 , pp. 159-165
    • Meyers, M.B.1    Scotto, K.W.2    Sirotnak, F.M.3
  • 20
    • 0024584440 scopus 로고
    • Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement
    • Naito, M., Tsuruo, T. (1989) Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement. Cancer Res. 49: 1452-1455
    • (1989) Cancer Res. , vol.49 , pp. 1452-1455
    • Naito, M.1    Tsuruo, T.2
  • 21
    • 0027406201 scopus 로고
    • Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance
    • Naito, M., Tsuge, H., Kuroko, C., Koyama, T., Tomida, A., Tatsuya, T., Heike, Y., Tsuruo, T. (1993) Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. J. Natl. Cancer Inst. 85: 311-316
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 311-316
    • Naito, M.1    Tsuge, H.2    Kuroko, C.3    Koyama, T.4    Tomida, A.5    Tatsuya, T.6    Heike, Y.7    Tsuruo, T.8
  • 22
    • 0029056457 scopus 로고
    • In-vivo and in-vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier
    • Ohnishi, T., Tamai, I., Sakanaka, K., Sakata, A., Yamashima, T., Yamashita, J., Tsuji, A. (1995) In-vivo and in-vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier. Biochem. Pharmacol. 49: 1541-1544
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1541-1544
    • Ohnishi, T.1    Tamai, I.2    Sakanaka, K.3    Sakata, A.4    Yamashima, T.5    Yamashita, J.6    Tsuji, A.7
  • 24
    • 0027998226 scopus 로고
    • In-vivo evidence for ATP-dependenl and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier
    • Sakata, A., Tamai, I., Kawazu, K., Deguchi, Y., Ohnishi, T., Saheki, A., Tsuji, A. (1994) In-vivo evidence for ATP-dependenl and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem. Pharmacol. 48: 1989-1992
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1989-1992
    • Sakata, A.1    Tamai, I.2    Kawazu, K.3    Deguchi, Y.4    Ohnishi, T.5    Saheki, A.6    Tsuji, A.7
  • 27
    • 0025966666 scopus 로고
    • P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for saturation of active daunorubicin transport
    • Spoelstra, E. C., Dekker, H., Schuurhuis, G. J., Broxterman, H. J., Lankelma, J. (1991) P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for saturation of active daunorubicin transport. Biochem. Pharmacol. 41: 349-359
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 349-359
    • Spoelstra, E.C.1    Dekker, H.2    Schuurhuis, G.J.3    Broxterman, H.J.4    Lankelma, J.5
  • 28
    • 0025103799 scopus 로고
    • Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells
    • Tamai, I., Safa, A. R. (1990) Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J. Biol. Chem. 265: 16509-16513
    • (1990) J. Biol. Chem. , vol.265 , pp. 16509-16513
    • Tamai, I.1    Safa, A.R.2
  • 29
    • 0022000211 scopus 로고
    • The absorption of β-adrenoreceptor antagonists in rat in-situ small intestine; the effect of lipophilicity
    • Taylor, D. C., Pownall, R., Burke, W. (1985) The absorption of β-adrenoreceptor antagonists in rat in-situ small intestine; The effect of lipophilicity. J. Pharm. Pharmacol. 37: 280-283
    • (1985) J. Pharm. Pharmacol. , vol.37 , pp. 280-283
    • Taylor, D.C.1    Pownall, R.2    Burke, W.3
  • 32
    • 0027290876 scopus 로고
    • Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein
    • Tsuji, A., Tamai, T., Sakata, A., Tenda, Y., Terasaki, T. (1993) Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46: 1096-1099
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1096-1099
    • Tsuji, A.1    Tamai, T.2    Sakata, A.3    Tenda, Y.4    Terasaki, T.5
  • 33
    • 0028029150 scopus 로고
    • Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism
    • Tsuji, A., Takanaga, H., Tamai, I., Terasaki, T. (1994) Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res. 11: 30-37
    • (1994) Pharm. Res. , vol.11 , pp. 30-37
    • Tsuji, A.1    Takanaga, H.2    Tamai, I.3    Terasaki, T.4
  • 34
    • 0022475690 scopus 로고
    • Characteristics of resistance to adriamycin in human myelogenous leukaemia K562 resistant to adriamycin and in isolated clones
    • Gann
    • Tsuruo, T., Iida-Saito, H., Kawabata, H., Ohhara, T., Hamada, H., Ulakoji, T. (1986) Characteristics of resistance to adriamycin in human myelogenous leukaemia K562 resistant to adriamycin and in isolated clones. Jpn J. Cancer Res. (Gann) 77: 682-692
    • (1986) Jpn J. Cancer Res. , vol.77 , pp. 682-692
    • Tsuruo, T.1    Iida-Saito, H.2    Kawabata, H.3    Ohhara, T.4    Hamada, H.5    Ulakoji, T.6
  • 35
    • 0026683912 scopus 로고
    • Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine
    • Watanabe, T., Miyauchi, S., Sawada, Y., Iga, T., Hanano, M., Inaba, M., Sugiyama, Y. (1992) Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine. J. Hepatol. 16: 77-78
    • (1992) J. Hepatol. , vol.16 , pp. 77-78
    • Watanabe, T.1    Miyauchi, S.2    Sawada, Y.3    Iga, T.4    Hanano, M.5    Inaba, M.6    Sugiyama, Y.7
  • 36
    • 0027987065 scopus 로고
    • Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers
    • Wils, P., Phung-Ba, V., Warnery, A., Lechardeur, D., Raeissi, S., Hidalgo, I., Scherman, D. (1994) Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem. Pharmacol. 48: 1528-1530
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1528-1530
    • Wils, P.1    Phung-Ba, V.2    Warnery, A.3    Lechardeur, D.4    Raeissi, S.5    Hidalgo, I.6    Scherman, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.