-
1
-
-
0027730961
-
Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport
-
Augustijins, P. F., Bradshaw, T. P., Gan, L.-S. L., Hendren, R. W., Thakker, D. R. (1993) Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport. Biochem. Biophys. Res. Commun. 197: 360-365
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.197
, pp. 360-365
-
-
Augustijins, P.F.1
Bradshaw, T.P.2
Gan, L.-S.L.3
Hendren, R.W.4
Thakker, D.R.5
-
2
-
-
0023205811
-
The cell biology of multiple drug resistance
-
Beck, W. T. (1987) The cell biology of multiple drug resistance. Biochem. Pharmacol. 36: 2879-2887
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 2879-2887
-
-
Beck, W.T.1
-
3
-
-
0026015774
-
Physiologic modeling of cyclosporin kinetics in rat and man
-
Bernareggi, A., Rowland, M. (1991) Physiologic modeling of cyclosporin kinetics in rat and man. J. Pharmacokin. Biopharm. 19: 21-50
-
(1991)
J. Pharmacokin. Biopharm.
, vol.19
, pp. 21-50
-
-
Bernareggi, A.1
Rowland, M.2
-
4
-
-
0027267598
-
Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells
-
Burton, P. S., Conradi, R. A., Hilgers, A. R., Ho, N. F. H. (1993) Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells. Biochem. Biophys. Res. Commun. 190: 760-766
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.190
, pp. 760-766
-
-
Burton, P.S.1
Conradi, R.A.2
Hilgers, A.R.3
Ho, N.F.H.4
-
5
-
-
0027345980
-
Structure and function of P-glycoprotein in normal liver and small intestine
-
Gatmaitan, Z. C., Arias, I. M. (1993) Structure and function of P-glycoprotein in normal liver and small intestine. Adv. Pharmacol. 24: 77-97
-
(1993)
Adv. Pharmacol.
, vol.24
, pp. 77-97
-
-
Gatmaitan, Z.C.1
Arias, I.M.2
-
7
-
-
0027818964
-
Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney
-
Hori, R., Okamura, N., Aiba, T., Tanigawara, Y. (1993) Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney. J. Pharmacol. Exp. Ther. 266: 1620-1625
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.266
, pp. 1620-1625
-
-
Hori, R.1
Okamura, N.2
Aiba, T.3
Tanigawara, Y.4
-
8
-
-
0026500180
-
The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa
-
Hsing, S., Gatmaitan, Z., Arias, I. M. (1992) The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology 102: 879-885
-
(1992)
Gastroenterology
, vol.102
, pp. 879-885
-
-
Hsing, S.1
Gatmaitan, Z.2
Arias, I.M.3
-
9
-
-
0025912228
-
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
-
Hunter, J., Hirst, B. H., Simmons, N. L. (1991) Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein. Br. J. Cancer 64: 437-444
-
(1991)
Br. J. Cancer
, vol.64
, pp. 437-444
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
10
-
-
0027180795
-
Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
-
Hunter, J., Hirst, B. H., Simmons, N. L. (1993) Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 10: 743-749
-
(1993)
Pharm. Res.
, vol.10
, pp. 743-749
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
11
-
-
0025374695
-
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
-
Hyde, S. C., Emsley, P., Hartshorn, M. J., Mimmack, M. M., Gileadi, U., Pearce, S. R., Gallagher, M. P., Gill, D. R., Hubbard, R. E., Higgins, C. F. (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346: 362-365
-
(1990)
Nature
, vol.346
, pp. 362-365
-
-
Hyde, S.C.1
Emsley, P.2
Hartshorn, M.J.3
Mimmack, M.M.4
Gileadi, U.5
Pearce, S.R.6
Gallagher, M.P.7
Gill, D.R.8
Hubbard, R.E.9
Higgins, C.F.10
-
12
-
-
0025972011
-
Modulation by verapamil of vincristine pharmacokinetics and sensitivity to metaphase arrest of the normal rat colon in organ culture
-
Ince, P., Elliott, K., Appleton, D. R., Moorghen, M., Finney, K. J., Sunter, J. P., Harris, A. L., Watson, A. J. (1991). Modulation by verapamil of vincristine pharmacokinetics and sensitivity to metaphase arrest of the normal rat colon in organ culture. Biochem. Pharmacol. 41: 1217-1225
-
(1991)
Biochem. Pharmacol.
, vol.41
, pp. 1217-1225
-
-
Ince, P.1
Elliott, K.2
Appleton, D.R.3
Moorghen, M.4
Finney, K.J.5
Sunter, J.P.6
Harris, A.L.7
Watson, A.J.8
-
13
-
-
0027146389
-
Transport of celiprolol across human intestinal epithelial (Caco-2) cells: Mediation of secretion by multiple transporters including P-glycoprotein
-
Karlsson, J., Kuo, S.-M., Ziemniak, J., Artursson, P. (1993) Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br. J. Pharmacol. 110: 1009-1016
-
(1993)
Br. J. Pharmacol.
, vol.110
, pp. 1009-1016
-
-
Karlsson, J.1
Kuo, S.-M.2
Ziemniak, J.3
Artursson, P.4
-
14
-
-
0018850819
-
Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
-
Komiya, I., Park, J. Y., Kamani, A., Ho, N. F. H., Higuchi, W. I. (1980) Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int. J. Pharm. 4: 249-262
-
(1980)
Int. J. Pharm.
, vol.4
, pp. 249-262
-
-
Komiya, I.1
Park, J.Y.2
Kamani, A.3
Ho, N.F.H.4
Higuchi, W.I.5
-
15
-
-
0028303363
-
The contribution of intestinal secretion to the dose-dependent absorption of celiprolol
-
Kuo, S.-M, Whitby, B. R., Artursson, P., Ziemniak, J. A. (1994) The contribution of intestinal secretion to the dose-dependent absorption of celiprolol. Pharm. Res. 11: 648-653
-
(1994)
Pharm. Res.
, vol.11
, pp. 648-653
-
-
Kuo, S.-M.1
Whitby, B.R.2
Artursson, P.3
Ziemniak, J.A.4
-
16
-
-
0028801904
-
Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
-
Leu, B.-L., Huang, J. D. (1995) Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother. Pharmacol. 35: 432-436
-
(1995)
Cancer Chemother. Pharmacol.
, vol.35
, pp. 432-436
-
-
Leu, B.-L.1
Huang, J.D.2
-
17
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
18
-
-
0019422355
-
A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry
-
Martin, Y. C. (1981) A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry. J. Med. Chem. 24: 229-237
-
(1981)
J. Med. Chem.
, vol.24
, pp. 229-237
-
-
Martin, Y.C.1
-
19
-
-
0025991880
-
P-glycoprotein content and mediation of vincristine efflux: Correlation with the level of differentiation in luminal epithelium of mouse small intestine
-
Meyers, M. B., Scotto, K. W., Sirotnak, F. M. (1991) P-glycoprotein content and mediation of vincristine efflux: correlation with the level of differentiation in luminal epithelium of mouse small intestine. Cancer Commun. 3: 159-165
-
(1991)
Cancer Commun.
, vol.3
, pp. 159-165
-
-
Meyers, M.B.1
Scotto, K.W.2
Sirotnak, F.M.3
-
20
-
-
0024584440
-
Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement
-
Naito, M., Tsuruo, T. (1989) Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement. Cancer Res. 49: 1452-1455
-
(1989)
Cancer Res.
, vol.49
, pp. 1452-1455
-
-
Naito, M.1
Tsuruo, T.2
-
21
-
-
0027406201
-
Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance
-
Naito, M., Tsuge, H., Kuroko, C., Koyama, T., Tomida, A., Tatsuya, T., Heike, Y., Tsuruo, T. (1993) Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. J. Natl. Cancer Inst. 85: 311-316
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 311-316
-
-
Naito, M.1
Tsuge, H.2
Kuroko, C.3
Koyama, T.4
Tomida, A.5
Tatsuya, T.6
Heike, Y.7
Tsuruo, T.8
-
22
-
-
0029056457
-
In-vivo and in-vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier
-
Ohnishi, T., Tamai, I., Sakanaka, K., Sakata, A., Yamashima, T., Yamashita, J., Tsuji, A. (1995) In-vivo and in-vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier. Biochem. Pharmacol. 49: 1541-1544
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 1541-1544
-
-
Ohnishi, T.1
Tamai, I.2
Sakanaka, K.3
Sakata, A.4
Yamashima, T.5
Yamashita, J.6
Tsuji, A.7
-
24
-
-
0027998226
-
In-vivo evidence for ATP-dependenl and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier
-
Sakata, A., Tamai, I., Kawazu, K., Deguchi, Y., Ohnishi, T., Saheki, A., Tsuji, A. (1994) In-vivo evidence for ATP-dependenl and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem. Pharmacol. 48: 1989-1992
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1989-1992
-
-
Sakata, A.1
Tamai, I.2
Kawazu, K.3
Deguchi, Y.4
Ohnishi, T.5
Saheki, A.6
Tsuji, A.7
-
25
-
-
0028924944
-
Reversal of multidrug resistance by a novel quinolone derivative, MS-209
-
Sato, W., Fukazawa, N., Nakanishi, O., Baba, M., Suzuki, T., Yano, O., Naito, M., Tsuruo, T. (1995) Reversal of multidrug resistance by a novel quinolone derivative, MS-209. Cancer Chemother. Pharmacol. 35: 271-277
-
(1995)
Cancer Chemother. Pharmacol.
, vol.35
, pp. 271-277
-
-
Sato, W.1
Fukazawa, N.2
Nakanishi, O.3
Baba, M.4
Suzuki, T.5
Yano, O.6
Naito, M.7
Tsuruo, T.8
-
26
-
-
0028229150
-
Distribution of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Sllinkel, A. H., Smit, J. J. M., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P. J., Berns, A. J. M., Borst, P. (1994) Distribution of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491-502
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Sllinkel, A.H.1
Smit, J.J.M.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.A.M.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.J.10
Berns, A.J.M.11
Borst, P.12
-
27
-
-
0025966666
-
P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for saturation of active daunorubicin transport
-
Spoelstra, E. C., Dekker, H., Schuurhuis, G. J., Broxterman, H. J., Lankelma, J. (1991) P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for saturation of active daunorubicin transport. Biochem. Pharmacol. 41: 349-359
-
(1991)
Biochem. Pharmacol.
, vol.41
, pp. 349-359
-
-
Spoelstra, E.C.1
Dekker, H.2
Schuurhuis, G.J.3
Broxterman, H.J.4
Lankelma, J.5
-
28
-
-
0025103799
-
Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells
-
Tamai, I., Safa, A. R. (1990) Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J. Biol. Chem. 265: 16509-16513
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 16509-16513
-
-
Tamai, I.1
Safa, A.R.2
-
29
-
-
0022000211
-
The absorption of β-adrenoreceptor antagonists in rat in-situ small intestine; the effect of lipophilicity
-
Taylor, D. C., Pownall, R., Burke, W. (1985) The absorption of β-adrenoreceptor antagonists in rat in-situ small intestine; The effect of lipophilicity. J. Pharm. Pharmacol. 37: 280-283
-
(1985)
J. Pharm. Pharmacol.
, vol.37
, pp. 280-283
-
-
Taylor, D.C.1
Pownall, R.2
Burke, W.3
-
30
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
Thiebaul, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., Willingham, M. C. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA 84: 7735-7738
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 7735-7738
-
-
Thiebaul, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
31
-
-
0026760889
-
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
-
Tsuji, A., Terasaki, T., Takabatake, Y., Tenda, Y., Tamai, I., Yamashima, T., Moritani, S., Tsuruo, T., Yamashita. J. (1992). P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51: 1427-1437
-
(1992)
Life Sci.
, vol.51
, pp. 1427-1437
-
-
Tsuji, A.1
Terasaki, T.2
Takabatake, Y.3
Tenda, Y.4
Tamai, I.5
Yamashima, T.6
Moritani, S.7
Tsuruo, T.8
Yamashita, J.9
-
32
-
-
0027290876
-
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein
-
Tsuji, A., Tamai, T., Sakata, A., Tenda, Y., Terasaki, T. (1993) Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46: 1096-1099
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1096-1099
-
-
Tsuji, A.1
Tamai, T.2
Sakata, A.3
Tenda, Y.4
Terasaki, T.5
-
33
-
-
0028029150
-
Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism
-
Tsuji, A., Takanaga, H., Tamai, I., Terasaki, T. (1994) Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm. Res. 11: 30-37
-
(1994)
Pharm. Res.
, vol.11
, pp. 30-37
-
-
Tsuji, A.1
Takanaga, H.2
Tamai, I.3
Terasaki, T.4
-
34
-
-
0022475690
-
Characteristics of resistance to adriamycin in human myelogenous leukaemia K562 resistant to adriamycin and in isolated clones
-
Gann
-
Tsuruo, T., Iida-Saito, H., Kawabata, H., Ohhara, T., Hamada, H., Ulakoji, T. (1986) Characteristics of resistance to adriamycin in human myelogenous leukaemia K562 resistant to adriamycin and in isolated clones. Jpn J. Cancer Res. (Gann) 77: 682-692
-
(1986)
Jpn J. Cancer Res.
, vol.77
, pp. 682-692
-
-
Tsuruo, T.1
Iida-Saito, H.2
Kawabata, H.3
Ohhara, T.4
Hamada, H.5
Ulakoji, T.6
-
35
-
-
0026683912
-
Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine
-
Watanabe, T., Miyauchi, S., Sawada, Y., Iga, T., Hanano, M., Inaba, M., Sugiyama, Y. (1992) Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine. J. Hepatol. 16: 77-78
-
(1992)
J. Hepatol.
, vol.16
, pp. 77-78
-
-
Watanabe, T.1
Miyauchi, S.2
Sawada, Y.3
Iga, T.4
Hanano, M.5
Inaba, M.6
Sugiyama, Y.7
-
36
-
-
0027987065
-
Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers
-
Wils, P., Phung-Ba, V., Warnery, A., Lechardeur, D., Raeissi, S., Hidalgo, I., Scherman, D. (1994) Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem. Pharmacol. 48: 1528-1530
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1528-1530
-
-
Wils, P.1
Phung-Ba, V.2
Warnery, A.3
Lechardeur, D.4
Raeissi, S.5
Hidalgo, I.6
Scherman, D.7
-
37
-
-
0028264139
-
Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporin A and SDZ PSC 833 in dependence on extracellular pH
-
Zacherl, J., Hamilton, G., Thalhammer, T., Riegler, M., Cosentini, E. P., Ellinger, A., Bischof, G., Schweitzer, M., Teieky, B., Koperna, T., Wenzl, E. (1994) Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporin A and SDZ PSC 833 in dependence on extracellular pH. Cancer Chemother. Pharmacol. 34: 125-132
-
(1994)
Cancer Chemother. Pharmacol.
, vol.34
, pp. 125-132
-
-
Zacherl, J.1
Hamilton, G.2
Thalhammer, T.3
Riegler, M.4
Cosentini, E.P.5
Ellinger, A.6
Bischof, G.7
Schweitzer, M.8
Teieky, B.9
Koperna, T.10
Wenzl, E.11
|