Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 1063-1069

  Yamaguchi, Hiroaki ^a   Yano, Ikuko ^a   Saito, Hideyuki ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; GREPAFLOXACIN; LEVOFLOXACIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFECT; DRUG ELIMINATION; DRUG TISSUE LEVEL; DRUG TRANSPORT; IN VIVO STUDY; INTESTINE SECRETION; MALE; MOUSE STRAIN; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; BILE; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; ENZYME INHIBITORS; FLUOROQUINOLONES; GENES, MDR; INTESTINES; KIDNEY; LIVER; MALE; MICE; MICE, KNOCKOUT; OFLOXACIN; P-GLYCOPROTEIN; PIPERAZINES; RATS; TISSUE DISTRIBUTION;

EID: 0036175308     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.1063     Document Type: Article

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