Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 5, 1997, Pages 2031-2035

  Sparreboom, Alex ^a,d   Van Asperen, Judith ^a   Mayer, Ulrich ^a   Schinkel, Alfred H ^a   Smit, Johan W ^b   Meijer, Dirk K F ^b   Borst, Piet ^a   Nooijen, Willem J ^a   Beijnen, Jos H ^c   Van Tellingen, Olaf ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

^d ERASMUS MC CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GLYCOPROTEIN P; PACLITAXEL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; BILIARY EXCRETION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EXCRETION; DRUG FECES LEVEL; DRUG UPTAKE; FEMALE; INTESTINE EPITHELIUM; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALIA;

EID: 12644278301     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.5.2031     Document Type: Article

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