Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

British Journal of Cancer

Volumn 83, Issue 3, 2000, Pages 375-383

  Evers, R ^a,d   De Haas, M ^a   Sparidans, R ^b   Beijnen, J ^b   Wielinga, P R ^c   Lankelma, J ^c   Borst, P ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

Drug transport; Glutathione; GS X pump; Multidrug resistance protein; Organic anion; Polarized cell

Indexed keywords

ANTINEOPLASTIC AGENT; BENZBROMARONE; DAUNORUBICIN; GLUTATHIONE; INDOMETACIN; MULTIDRUG RESISTANCE PROTEIN; PROBENECID; SULFINPYRAZONE; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STOICHIOMETRY;

EID: 0033936291     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1262     Document Type: Article

References (37)

1. Bakos E, Evers R, Szákacs G, Tusnády GE, Welker E, Szabó K, de Haas M, van Deemter L, Borst P, Váradi A and Sarkadi B (1998) Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. J Biol Chem 273: 32167-32175
2. Bakos E, Evers R, Sinko E, Varadi A, Borst P and Sarkadi B (2000) Interaction of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol 57: 760-768
3. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T and Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic rats. J Biol Chem 271: 15091-15098
4. Chu XY, Kato Y and Sugiyama Y (1997) Multiplicity of biliary excretion mechanism for irinotecan, CPT11, and its metabolites in rats. Cancer Res 57: 1934-1938
5. Cole SPC and Deeley RG (1998) Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP. Bioassays 20: 931-940
6. Cole SPC, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM and Deeley RG (1994) Pharmacological characterization of multidrug resistant MRP-transfected human tumour cells. Cancer Res 54: 5902-5910
7. Cui Y, Buchholz JK, Spring H, Leier I and Keppler D (1999) Drug resistance and ATP dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human an canine cells. Mol Pharmacol 55: 929-937
8. Evers R, Zaman GJ, van Deemter L, Jansen H, Calafat J, Oomen LC, Oude Elferink RP, Borst P and Schinkel AH (1996) Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J Clin Invest 97: 1211-1218
9. Evers R, Kool M, van Deemter L, Janssen H, Calafat J, Oomen LCJM, Paulusma CC, Oude Elferink RPJ, Baas F, Schinkel AH and Borst P (1998) Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 101: 1310-1319
10. Feller N, Broxterman HJ, Währer DCR and Pinedo HM (1995) ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. FEBS Lett 368: 385-388
11. Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA and Pastan 1 (1995) Genetic analysis of the multidrug transporter. Annu Rev Genet 29: 607-649
12. Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV and Lankelma J (1997) Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochem Biophys Acta 1326: 12-22
13. Higgins CF (1992) ABC-transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113
14. Holló Z, Homolya L, Hegedus T and Sarkadi B (1996) Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells. FEBS Lett 383: 99-104
15. Horio M, Chin K-V, Currier SJ, Goldenberg S, Williams C, Pastan 1 and Gottesman MM (1989) Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J Biol Chem 264: 14880-14884
16. Ishikawa T (1992) The ATP-dependent glutathione S-conjugate pump. Trends Biochem Sci 17: 463-468
17. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272: G16-22
18. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1998) Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 273: 1684-1688
19. Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G and Keppler D (1996) Transport of glutathione, glucuronate, and sulphate conjugate by the MRP gene-encoded conjugate export pump. Cancer Res 56: 988-994
20. Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchel B and Keppler D (1997) ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327: 305-310
21. Leier I, Jedlitschky G, Buchholz U, Cole SPC, Deeley RG and Keppler D (1994) The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269: 27807-27810
22. Loe DW, Almquist KC, Cole SPC and Deeley RG (1996) Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. J Biol Chem 271: 9683-9689
23. Loe DW, Deeley RG and Cole SPC (1998) Characterization of vincristine transport by the M(r) 190 000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione. Cancer Res 58: 5130-5136
24. Masuda M, I'izuka Y, Yamazaki M, Nishigaki R, Kato Y, Ni'inuma K, Suzuki H and Sugiyama Y (1997) Methotrexate is excreted into bile by the canalicular multispecific organic anion transporter in rats. Cancer Res 57: 3506-3510
25. Müller M, Meijer C, Zaman GJR, Borst P, Scheper RJ, Mulder NH, de Vries EGE and Jansen PLM (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91: 13033-13037
26. Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK and Groothuis GMM (1995) Hepatobiliary secretion of organic compounds, molecular mechanism of membrane transport. Biochem Biophys Acta 1241: 215-268
27. Paulusma C, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P and Oude Elferink RPJ (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271: 1126-1128
28. Paulusma C, Kool M, Bosma PJ, Scheffer GL, ter Borg F, Scheper RJ, Borst P, Baas F and Oude Elferink RPJ (1997) A mutation in the human cMOAT gene causes the Dubin-Johnson syndrome. Hepatology 25: 1539-1542
29. Paulusma CC, van Geer MA, Evers R, Heijn M. Ottenhoff R, Borst P and Oude Elferink RPJ (1999) Canalicular multispecfic organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 338: 393-401
30. Rappa J, Lorico A, Flavell RA and Sartorelli AC (1997) Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. Cancer Res 57: 5232-5237
31. Taguchi Y, Yoshida A, Takada Y, Komano T and Ueda K (1997) Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP). FEBS Lett 401: 11-14
32. Tew KD (1994) Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54: 4313-4320
33. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502-522
34. Versantvoort CHM, Broxterman HJ, Bagrij T, Scheper RJ and Twentyman PR (1995) Regulation by glutathione of drug transport in multidrug resistant human lung tumour cell lines overexpressing MRP. Br J Cancer 72: 82-89
35. Wielinga PR, de Waal E, Westerhoff HV and Lankelma J (1999) In vitro transepithelial drug transport by on-line measurement: cellular control of paracellular and transcellular transport. J Pharm Sci 88: 1340-1347
36. Zaman GJ, Flens MJ, van Leusden MR, de Haas M, Mulder HS, Lankelma J, Pinedo HM, Scheper RJ, Baas F, Broxterman HJ and Borst P (1994) The multidrug resistance-associated protein MRP is a plasma membrane efflux pump. Proc Natl Acad Sci USA 91: 8822-8826
37. Zaman GJR, Lankelma J, van Tellingen O, Beijnen J, Dekker H, Paulusma CC, Oude Elferink RPJ, Baas F and Borst P (1995) Role of glutathione in the export of compounds from cells by the multidrug resistance-associated protein. Proc Natl Acad Sci USA 92: 7690-7694